A Kinetics-first Approach Reveals Optimum Vinylaminopyrimidines for Cysteine-Based Antibody Conjugation – an exciting collaboration with @scrippsresearch colleagues @Dawson_Group and the Blackmond group along with BMS – appearing now in @ChemRxiv : https://t.co/4f4UdZSkZ0
Breaking radio silence with 2x #ChemEd#Chemistry summaries of aldol-like reactions. These are just lists of reactions. One tries to include mechanisms. More a stop gap than anything else (things have been hectic). Hopefully, someone will find them useful. Enjoy.
Chiral Isourea-Catalyzed Enantioselective Carbene Insertion into an N–H Bond through a Double Proton-Transfer Process | Journal of the American Chemical Society https://t.co/tGR5kkHTp9
Safety First in Organic Chemistry! ⚠️
#OrgLett published its first "Safety Letter" by Garg, Zhao, and co-workers, spotlighting IBX—a widely used oxidant with explosive potential.
Read the Safety Letter and Editorial in this week's issue:
https://t.co/OG8wy0KcOu
📢We are hiring! We offer a fully funded 2-year #Postdoc position to join our team at
@Stockholm_Uni
Do you want to work in heterogeneous catalysis with MOFs and make organic synthesis more sustainable? Apply here until 28/12 #chemtwitter RTs appreciated!
https://t.co/cT07OxxBUp
Pero todo conjunto matemático o explicación más allá de las dimensiones pobremente conocidas, pero ampliamente estudiadas, tiene una solución real o imaginaria.
No new #ChemEd#Chemistry summary today, just an attempt to summarise the alkene chemistry that has been covered in the last couple of infographics. It also acts as a spoiler for next week's look at anti-Markovnikov addition.
Hopefully it still has some use.
Simple, Enantiocontrolled Azetidine Library Synthesis via Strain Release Functionalization of 1-Azabicyclobutanes. A fantastic collaboration with the Cravatt lab.
A simple, modular, programmable approach to access complex stereopure azetidines through strain-release functionalization is disclosed. The synthetic methods developed enable parallel synthesis of stereodefined azetidines that would be otherwise laborious to produce. Given the privileged nature of these structures, a set of stereoprobes for use in activity-based protein profiling was prepared and evaluated, revealing proteins in human cancer cells with were liganded with clear stereo- and chemoselectivity.
Appearing today in @ChemRxiv : https://t.co/ATPRy8yYan
A new #Chemistry#ChemEd summary looking at variants of the Diels-Alder reaction. As always, it isn't a deep dive, I just wanted to show that the DA rct is really useful. I mention catalysis but there will be more detail in the wordy version next week. Hope it is useful & enjoy.
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Más info por DM
Now hiring! We have an available PDRA position available in the group investigating photochemical coupling reactions. Deadline closing soon - please see the link for more details.
https://t.co/OQPbM6hhQl