Rohan Bythell-Douglas

Melbourne based researcher studying enzymes that repair DNA damage.
@SVIResearch @GenomeStability

[Rohan Bythell-Douglas @RBDdoesDNA]

Stoked to have submitted this fun, insightful paper on branched DNA recognition by FANCM

[🔬Andrew Deans🇦🇺 @GenomeStability]

We have a new lab preprint! Led by @LaraAbbouche and @RBDdoesDNA + collaboration with @HildaAPickett lab, we identify the mechanism of structure specific DNA binding of FANCM, and its contribution to the survival of ALT-positive cancers: https://t.co/taBzqJTcpt

[Rohan Bythell-Douglas @RBDdoesDNA]

Well done Lara!

[Lakshmi Wijeyewickrema @wlakshmi]

Congratulations! More poster prizes @LorneProteins 2024

[Lakshmi Wijeyewickrema @wlakshmi]

@RBDdoesDNA wearing the @LorneProteins tshirt wonderfully well.

[Rohan Bythell-Douglas @RBDdoesDNA]

A neat investigation on the disruption of D-loops by BLM helicase and the BTRR complex using some cleverly designed DNA substrates. Surprising there is no extension of the D-loop in front of the invading strand
https://t.co/bCcgXW9sJj #DNArepair #helicase #topoisomerase #DNA

[🔬Andrew Deans🇦🇺 @GenomeStability]

New from our lab @PNASNews: We purified intact Bloom Syndrome complex and determined its assembly and activity in #DNArepair. Using biochemical, biophysical & cell-based methods we uncovered interactions within the complex necessary for genome stability /1
https://t.co/hWb04rbnlQ

[Rohan Bythell-Douglas @RBDdoesDNA]

A great review article from the group of @benjaminsgully on the state of SARS-COV-2 drugs and therapies with a satisfying structural perspective
https://t.co/hxhu46hbcp #COVID19 #structuralbiology

[Fyodor Urnov @UrnovFyodor]

If I could, I'd have every college Bio1A student watch this superbly cogent explanation by Dr Cynthia Wolberger @CWolberger of what Rosalind Franklin's X-ray crystallographic dataset told us about DNA structure. Two minutes of magnificence. #WomenInSTEM
https://t.co/TflJn8BrjL

[Rohan Bythell-Douglas @RBDdoesDNA]

FANCM directly interacts with the BLM-Top3a-RMI complex to drive telomere extension in ALT cancers (~15% of cancers). Disruption of this interaction specifically kills ALT cancer cells via rampant genome instability. https://t.co/QJKKAIjIRB #genomeinstability

[Rohan Bythell-Douglas @RBDdoesDNA]

Mus81-Eme1 cleaves both strands of a Holliday junction symetrically and cooperatively as a heterotetramer. The second strand is cleaved at much higher efficiency than the first. https://t.co/N9jW1nynBD #HollidayJunction #DNArepair

[Rohan Bythell-Douglas @RBDdoesDNA]

Single molecule FRET shows that RuvC exploits and then constrains intrinsic Holliday junction dynamics, for efficient sequence and structure specific resolution. https://t.co/WNpKylgPQV #DNArepair #singlemolecule