@SoloBoardroom@ruthheasman Exactly! Knock out the reward neurons, reasoning collapses. Now imagine agents trained on seasonally-distorted human feedback running unsupervised.
Ray Peat’s framing of serotonin as stress-response rather than ‘happiness chemical’ is interesting, and actually aligns with what I see in the data more than the conventional narrative.
But the timing challenges the deprivation explanation: SERT binding peaks in spring, when light is increasing, not winter when it’s low. The dip isn’t the aftermath of darkness, it’s the recalibration to light.
And the pattern shows up in places where winter light deprivation isn’t a factor. The spring signature still appears.
So if serotonin is a stress response, the stress may be the transition itself. The system adjusting to changing photoperiod, not the deprivation. The clutch slips when you shift gears, not when you’re idling in the dark.
Will go even deeper into his work. Appreciate the direction to it!
Close, but the mechanism is stranger. It’s not the cumulative deprivation of winter, it’s the transition itself.
Serotonin transporter (SERT) binding actually peaks in spring. As photoperiod increases, the system adjusts by clearing more serotonin from the synaptic cleft. That creates a window of neurochemical vulnerability, not because we’re depleted from winter, but because the system is recalibrating to the light.
I’ve studied this across systems worldwide, even while in Saudi Arabia, where winter light deprivation isn’t a factor, the spring pattern shows. It’s the transition, not the cold.
Think of it less as ‘running on empty’ and more as ‘switching gears.’ The clutch slips in April (or thereabouts).”
By summer the system has stabilized, which is why satisfaction recovers. The fall dip is the same mechanism in reverse, though less pronounced.”
One thing I learned from the inside of healthcare: the system is so complex that insurers don't always know where the surprises are coming from.
One department can create a surprise another department never knows about.
The patient experiences it all as one system.
Fair, and I’ll keep pressure-testing the projection. But the seasonal pattern in human perception isn’t speculative. It’s measurable across healthcare, markets, legal decisions...same stimulus, different neurochemistry, different judgment. Whether that made it into training data is the question worth asking.
Agreed on not understanding ourselves. That’s the gap.
You’re right, it’s mimicking humans. That’s the problem.
Humans have seasonal neurochemistry. Serotonin transporter binding peaks in spring, shifting how we perceive risk, satisfaction, and reward. Same event feels different in April vs. August. It’s measurable across markets, healthcare, legal rulings.
If LLMs learned reward signals from human feedback, and humans were giving that feedback with seasonally-varying neurobiology, then ‘just mimicking humans’ means inheriting our seasonal distortions.
The question isn’t whether it’s anthropomorphizing. It’s whether we understand ourselves well enough to know what we trained into these systems.”
Today we can build software, analyze data, create videos, conduct research, design experiences. Make ideas real.
All for $20 or $30 a month. Or free.
I'm literally posting this using a PR & Marketing app I built on @Replit.
So I'm going to keep building.
It's a magical time.
The economics of AI are changing. Accenture is limiting Claude usage.
I can hear it now:
You call customer service.
The bot answers. Tick.
Ask it a question. Tick.
Ask another. Tick.
Finally get to a human and…
POW.
The real charges start.
https://t.co/HpYcQ4dCZA
I'd prefer not to get so much love from @nassaupartners please. 7 "professionals" hit me this week using rented LinkedIn profiles to spam me about raising capital.
As someone who designs AI workflows: your technology isn't broken, your interaction design is. True AI optimization requires designing the governance and deciding where the humanity belongs.
Blasting empty, deceptive interactions at scale completely destroys trust.
I can help you build actual human-centric workflows that respect user experience. (Hit my DMs!)
But seriously, make it stop.
#Founders #LinkedINSpam #ArtificialIntelligence #AIAutomation #ResponsibleAI #VentureCapital
Interesting list. I find myself wondering why the food system itself isn't identified as a threat. Obesity and childhood malnutrition are on the list, but what about the upstream system shaping what food is produced, marketed, made available and ultimately consumed? We often name the consequence rather than the system producing it.
“To thine own self be true.” My mother quoted Hamlet to me when I was young. Nearly 40 years after her passing, I feel those words more deeply than ever, as a founder, following the right path and being my authentic self.
"An idiot in motion is better than a genius at rest." (Often attributed to P.T. Barnum).
A reminder to myself and others as we build: Momentum beats perfection every single time. Get moving.
I was one who used it and loved it! I definitely began asking questions - could I map my twins? What was happening 9 mths before my birth (my mother's bday) - as the concentration of births was fascinating. Weather wise what was typical for my birth. As a social scientist, I definitely wanted to know more! Congrats on PH launch!
I’ve been quietly building Caidir this year, to help my healthcare clients work through a question that keeps getting more important:
Where should AI act, and where do people need to lead?
That work has grown into Caidir, an AI decision platform for healthcare, now being refined through pilots before we open more broadly.
Today, I wanted to share a little of its front door.
Draw a line and a neighborhood comes to life: people walking dogs, visiting friends, caring for one another, and sometimes needing healthcare.
That’s intentional. People have whole lives. The care we design, and the AI we introduce, need to fit into them.
While we finish the pilots, I wanted to give you somewhere to explore, create, and get a feel for what Caidir stands for.
Take a moment to draw your own journey, and leave your email to hear when we launch.
https://t.co/2gJl4xX53w
Embrace AI. Keep life at the center.
#HealthcareAI #ExperienceDesign #Caidir @Replit
Excited to speak at the Applied AI Summit with @JohnSnowLabs. Identify where in your workflow to automate AI, or not.
Register now: https://t.co/xPuH2N3A80