Radical Ventures

Venture Capital fund focused on Artificial Intelligence and deep tech. Offices in Toronto and San Francisco, and partners in London and New York.

[Radical Ventures @radicalvcfund]

On the latest Radical Talks podcast: @GeoffreyHinton X @JeffDean - a friendship that defined modern AI as breakthrough theories met massive scale. Recorded at #NeurIPS2025, Radical Co-Founder @JordanJacobs10 sits down with these two icons of AI to discuss one of history’s most productive collaborations.

[Radical Ventures @radicalvcfund]

Together, they're working on AI that doesn't just generate video — it understands physics, simulates motion, and enables robots to act in the real world. Looking forward to seeing what these teams accomplish together.

[Radical Ventures @radicalvcfund]

@RekaAILabs has joined forces with @moonvalley, adding researchers and engineers behind some of the most advanced video generation and multimodal models in the field, including former DeepMind scientists who were core contributors to Google's Veo. https://t.co/rznm0V36SE

[Radical Ventures @radicalvcfund]

Sessions are exclusive to Masterclass participants. Apply now to hear from Yann and other AI luminaries: https://t.co/H6QxqMBRMd

[Radical Ventures @radicalvcfund]

@ylecun is joining our 2026 AI Founders Masterclass as a keynote speaker.

[Radical Ventures @radicalvcfund]

Yann LeCun is Executive Chairman of @amilabs and a Professor at @nyuniversity. A Turing Award winner, he was the Chief AI Scientist of Meta, the founding Director of Meta-FAIR, and of the NYU Center for Data Science. His foundational work on convolutional neural networks and deep learning has helped shape the field of modern AI.

[Radical Ventures @radicalvcfund]

In this week's #RadicalReads, we announce our lead investment in @GeneralistAI 's $400M Series B. The company is building general-purpose foundation models to power the next generation of robotics: https://t.co/kSaPD2ineS

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If you're an AI researcher considering commercialization or an early-stage founder building in AI, this program was made for you. Stay tuned for more announcements — we have a remarkable speaker lineup coming.

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Applications are now open for the 2026 Radical Ventures AI Founders Masterclass, running October 7–28: https://t.co/kkM8YLvVi8

[Radical Ventures @radicalvcfund]

The Masterclass brings together AI researchers from Stanford, MIT, Oxford, Cambridge, and premier institutes like Vector and Mila, alongside entrepreneurs who are already building the future.

[Radical Ventures @radicalvcfund]

@genesismolai's Pearl system has beaten every other cofolding model tested — reaching 78% on OpenBind's primary success metric. This was achieved with no target-specific tuning, demonstrating Pearl's ability to generalize to new targets. Congratulations to the team.

[Genesis Molecular AI @genesismolai]

Today we're sharing new breakthrough results for Pearl, our foundation model for protein–ligand cofolding.

The OpenBind Consortium recently released the first public structure-affinity benchmark for molecular AI, evaluating six prominent cofolding models on the EV-A71 2A protease. We ran our full Pearl system against the same target.

Zero-shot, with no binding-site information and no tuning, the Pearl system reaches 78% on OpenBind's primary success criteria, far ahead of every cofolding model tested by OpenBind. We also assessed a stricter sub-1 Å accuracy threshold, which is more relevant for real-world R&D usage – the Pearl system’s success is still 60%, versus 1–27% for the other models.

What matters most to us: this is the same system setup our scientists use on live drug discovery programs, not a benchmark-specific configuration.

Thanks to the OpenBind Consortium for building a rigorous public benchmark, and to @NVIDIAHealth for the support on optimizations that enabled model scaling.

[Radical Ventures @radicalvcfund]

In this week's #RadicalReads, Radical Partner Aaron Rosenberg explores our Seed investment in @inherent_labs. Inherent is building an AI lab designed around recursive self-improvement: https://t.co/8NBdAH50SB

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4️⃣ How founders compete: your first hires are cultural co-founders, not just employees. The companies winning on talent right now are the ones with the clearest vision, the most intentional early teams, and a compelling answer to the frontier lab threat.

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Our latest episode of Radical Talks is live! Tune in to hear from @YLikomanova, Senior Director of Talent at Radical Ventures, in conversation with Radical Partner @molwelch on the forces shaping AI talent flows.

[Radical Ventures @radicalvcfund]

3️⃣ The forward deployed engineer: why FDEs have become one of the most sought-after and least understood roles in applied AI, what the ideal background looks like, and why supply remains critically short.