Rheum Journal Club

Rheumatology Journal Club on Twitter: #RheumJC

[Nephrology Journal Club @NephJC]

Belimumab and Lupus Nephritis: A Marriage made by B Cells? https://t.co/5qociep8nv

[Rheum Journal Club @RheumJC]

The @NephJC team is going to be discussing the Belimumab in #LupusNephritis (BLISS LN) for #NephJC on Nov 24/25 #RheumJC

[Rheum Journal Club @RheumJC]

The @NephJC team is going to be discussing the Belimumab in #LupusNephritis (BLISS LN) for #NephJC on Nov 24/25 #RheumJC

[Rheum Journal Club @RheumJC]

Taking suggestions for #RheumJC articles for this month.

Any papers you’d like to see discussed?

[Jeffrey Sparks MD MMSc @jeffsparks]

@RheumJC @AriellaStudies @ChewChrissie @JYazdanyMD @MilenaGianfran the differences in p values in tables are likely due to confounding. unadjusted there seems to be a difference for smokers and risk of hospitalization, but in the multivariable models the association was explained by other factors such as chronic lung disease #RheumJC

[Rheum Journal Club @RheumJC]

@Ann26217989 @DoctorRheum We collect data on this... hopefully enough to report on it in the next paper.

[Rheum Journal Club @RheumJC]

@AriellaStudies @ChewChrissie Maybe @JYazdanyMD or @MilenaGianfran would be better able to explain this.

[Rheum Journal Club @RheumJC]

Alright... thanks again. Good night everyone! (if there are follow up questions, tag me @psufka and/or @rheum_covid, and I can try to answer in the AM). #RheumJC

[Rheum Journal Club @RheumJC]

Also, given initial limited testing supplies, only most severe and "classic" cases were tested.

Would be really interesting to see a case series of "asymptomatic" rheum pts. #RheumJC

[Jinoos Yazdany @JYazdanyMD]

@jeffsparks @RheumJC @BolekBerqui @zach_wallace_md We’ve started doing systematic antibody testing in our rheum clinic and it’s amazing how many people have antibodies (esp our Latinx population) and were asymptomatic. So I think the registry skews to severe patients.

[Rheum Journal Club @RheumJC]

@BolekBerqui 😬

[Rheum Journal Club @RheumJC]

Wow, this hour went by fast! I'll stick around for a little bit longer... but then I have to get my kid to bed.

Just want to thank everyone for joining the discussion tonight! And thanks to everyone who put in so much work into this project! #RheumJC

[Rheum Journal Club @RheumJC]

@JYazdanyMD @jeffsparks @BolekBerqui https://t.co/7C2ZIWTtnF #RheumJC

[Rheum Journal Club @RheumJC]

@jeffsparks @BolekBerqui As usual, steroids are bad until they're not. #RheumJC

[Rheum Journal Club @RheumJC]

How has this paper (and any other data) has changed your clinical practices over the course of this pandemic?
#RheumJC

[Rheum Journal Club @RheumJC]

#RheumJC

[Jinoos Yazdany @JYazdanyMD]

@RheumJC @jeffsparks @BolekBerqui So interesting that the no oxygen group in the dex trial looked like they did a little worse. Would make sense if steroids worse early in the disease, but helpful in late inflammatory phase. But this still needs to be proven.

[Rheum Journal Club @RheumJC]

@jeffsparks @BolekBerqui As usual, steroids are bad until they're not. #RheumJC

[Rheum Journal Club @RheumJC]

#RheumJC

[Jinoos Yazdany @JYazdanyMD]

@PatelAarat @RheumJC @philipcrobinson Here’s the first IBD paper: https://t.co/ksBomO4Hwl

[Aarat Patel, MD @PatelAarat]

@RheumJC This has helped the “going back to work and school” conversation. It is still a personal decision. This paper and the data that will come in the next few months makes it less of a medical decision and more of a personal/family decision. #rheumjc

[Rheum Journal Club @RheumJC]

#RheumJC 🙏

[Mithu Maheswaranathan, MD @MithuRheum]

@RheumJC This paper helped create a more informed discussion with patients on potential risks of medications. Helped provide some reassurance when prescribing new DMARDs too

[Rheum Journal Club @RheumJC]

This pandemic has had some examples of really bad science. Hopefully we learn from these mistakes.
#RheumJC

[Jeffrey Sparks MD MMSc @jeffsparks]

@RheumJC @philipcrobinson We don't like poorly performed "non-randomized" CTs and retracted observational studies #hcqbrigade @alhkim @EBRheum

[Rheum Journal Club @RheumJC]

For me:
-throughout the pandemic, I've been more aggressive to get people off prednisone than even my usual
- before data, I did try to slightly ween down/spread out DMARDs a bit, esp in pts that were in remission -- I don't feel the need to do this any more
#RheumJC

[Rheum Journal Club @RheumJC]

How has this paper (and any other data) has changed your clinical practices over the course of this pandemic?
#RheumJC

[Aarat Patel, MD @PatelAarat]

@Ann26217989 @RheumJC We were all probably reluctant to prescribe biologics/JAK’s in March/April because there was so much unknown about #covid19. There still is but this paper helps the conversation. #rheumjc