Rik Dhar

A biochemistry researcher

[Joanna Slusky 🫖 @SluskyLab]

🚨New Paper🚨on a reason for why outer membrane proteins fold easily in vitro but require BAM in vivo, why they don’t fold back into the inner membrane, and how folding antibiotic resistance pumps can go wrong.

https://t.co/aissErt6BW

A thread 1/

[Rik Dhar @Rik_Skywalker]

@KarenFlemingPhD @SluskyLab Thank you!

[Rik Dhar @Rik_Skywalker]

I successfully defended my doctoral dissertation, on Nov 8th. I am grateful to my mentor @SluskyLab, for her continuous support and guidance, & to my collaborators and lab mates, who made this journey much easier.

Looking forward to the next phase of my career!
#phdone #grateful

[KU Molecular Biosciences @KUMolBio]

Congratulations MB graduates!

[eLife - the journal @eLife]

Repurposing bacterial weapons could offer a way to reduce antibiotic resistance. https://t.co/d6vopQzvkt

[Joanna Slusky 🫖 @SluskyLab]

🚨New Paper 🚨
TolC is the outer membrane protein that pushes antibiotics out of E. coli. We’ve been working for a while on trying to disable this pump. 1/ 🧵 https://t.co/p943gRLfFG

[Dr Matthew Doyle @DoyleMT1]

**ONLINE NOW!**
@hbernstein16 and I are delighted that our paper using Cryo-EM and in vivo assays to understand outer membrane protein folding has found a home at Cell! @CellCellPress
Here is a free access link to the article: https://t.co/hAsd8KIlhQ
1/3

https://t.co/DSKQfHyU2h

[Giovanni Maglia @MagliaGiovanni]

Check out our two new approaches to single-molecule protein sequencing using a proteasome-nanopore!
A full protein can be unfolded and threaded at a controlled speed, or chopped and (eventually) read in pieces!
Amazing work from postodc S. Zhang
https://t.co/PeQN1ZN6Hf

[Joanna Slusky 🫖 @SluskyLab]

🚨New paper🚨
This paper came about because we often talk in lab about how outer membrane beta barrels are inside out soluble barrels-- it's a concept that's intuitive but not obvious how to demonstrate 1/n https://t.co/ZkIpmsVzZi

[Joanna Slusky 🫖 @SluskyLab]

New mini-review!
Want to know how outer membrane proteins evolved?
https://t.co/053yzqiMEa

[Rik Dhar @Rik_Skywalker]

Outer membrane protein evolution https://t.co/tfl5CeK8kD

[Nature Portfolio @NaturePortfolio]

The findings of a study in Nature demonstrate the potential of in vivo base editing as a possible treatment for Hutchinson–Gilford progeria syndrome and other genetic diseases by directly correcting their root cause. https://t.co/9FMUuY3TzA

[KU Molecular Biosciences @KUMolBio]

Two palettes of spin columns for covid-19 testing donated to the state of Kansas by KU research labs! @GovLauraKelly @ResearchAtKU @KU_EEB @kuanthro Others?

[Currie-Lab Ants @uwcurrielab]

Check out @NPR article Bugs vs Superbugs! Highlighting insect Streptomyces to combat antimicrobial resistance from our @NatureComms publication. @UWMadison @uwgenetics @UWMadisonCALS
https://t.co/IxZseDSPtw

[The Nobel Prize @NobelPrize]

What is autophagy? It’s a process whereby the eukaryotic cell can recycle part of its own content #NobelPrize 2016

[Rik Dhar @Rik_Skywalker]

My first tweet! :)