Michael Padberg Jr.

Dad and MIZZOU Sports Fan

[Michael Padberg Jr. @RipEmUpTigers]

Episode 3: Autoimmune Statin Induced Myopathy: What Everyone Needs to Know https://t.co/yVulTB4Doi via @YouTube

[Behnood Bikdeli @bbikdeli]

#Antiphospholipid antibodies and #cardiovascular #thrombosis, now in @NatRevCardiol 👇:

https://t.co/JuVuLs3s16

Systematic summary across various conditions. In some cases, we challenge the old conventional thinking...

Truly multidisciplinary, led by our 🌟fellow @SinaRsh

[Dr. John Cush @RheumNow]

FDA has granted Fast Track designation to J&Js nipocalimab for use in #SLE based on the results of a Phase 2b JASMINE study in which nipocalimab demonstrated reduction in lupus disease activity and potential for steroid sparing https://t.co/puQN6ecScj

[Dr. John Cush @RheumNow]

Antimitochondrial antibodies (AMA)in systemic sclerosis? Retro study of 165 SSc pts (20% diffuse, 33% ILD, 7% PAH); 51% centromere AB+; 29% topoisomerase I+, 12% RNA polymerase III+)-- 22% AMA-positive: assoc w/ GI vascular dz(OR 13.3), gastric antral vascular ectasia (OR 8) & may be cause for GI bleeding, refractory Fe-deficiency anemia https://t.co/ciifxmOtsX

[Steven Crowder @scrowder]

ICE was LITERALLY arresting a child sex offender when these protesters tried to stop it.

At what point does the Left examine themselves and go “Okay, maybe WE ARE the bad guys?"

[Dr. John Cush @RheumNow]

Anti-mitochondrial M2 Ab (AMA-M2) in 987 IIM pts-- 55 (6%) were AMA-M2 positive. AMA-M2+ had signif. higher rates of polymyositis (56% vs 23.5%), GGT, alk phos levels, & 3 fold more cardiac involvement (60 vs 13%) (arrhythmias, CHF, pulm HTN (31-56%), but no effect on survival https://t.co/YFojfbXEAY

[Aravind Palraj @Rheumat_Aravind]

Low-titre ANA is frequently overinterpreted.

• Seen in up to 20–30% of healthy adults
• Often benign and transient
• ANA is a screening test, not a diagnosis

A major pitfall:
Mislabeling low-titre ANA positivity as lupus in asymptomatic young women.

Clinical context > lab reports.
Reassurance is often correct care.

#Rheumatology #MedEd #ANA #MedTwitter @DrAkhilX @Janetbirdope @IhabFathiSulima #ClinicalReasoning #InternalMedicine

[Nick shirley @nickshirleyy]

🚨 Here is the full 42 minutes of my crew and I exposing Minnesota fraud, this might be my most important work yet. We uncovered over $110,000,000 in ONE day. Like it and share it around like wildfire! Its time to hold these corrupt politicians and fraudsters accountable

We ALL work way too hard and pay too much in taxes for this to be happening, the fraud must be stopped.

[Michael Padberg Jr. @RipEmUpTigers]

@MizzouFootball

[Michael Padberg Jr. @RipEmUpTigers]

@MizzouFootball Two absolute UNITS!! MIZ!!

[Luis Caminal @caminalm]

Update on therapeutic approaches in ANCA-associated vasculitis https://t.co/c4rgq4Hc7m

[ACR_Journals @ACR_Journals]

A high ANA titer (≥1:640) in individuals without an autoimmune disease was found to be strongly associated with liver-related disorders, including nonalcoholic and alcoholic liver disease

Arthritis Care & Research
https://t.co/tkMpPFPnhc

[Aravind Palraj @Rheumat_Aravind]

Anti-CCP vs RF in suspected RA:

RF is older and less specific; false positives occur with infections, cryoglobulinemia, liver disease, and in the elderly.

Anti-CCP is highly specific and predicts erosive disease.

Best practice: order both and interpret with the clinical picture.
@DrAkhilX @IhabFathiSulima
#Rheumatology #RA #MedTwitter

[Aravind Palraj @Rheumat_Aravind]

🔬 Anti-dsDNA: Not just specific for SLE, but a direct clue to flare risk — especially lupus nephritis.
📈 Rising dsDNA + falling C3/C4? Think renal flare!
Consistent monitoring is key; trends matter more than single results.
@DrAkhilX @IhabFathiSulima @CelestinoGutirr #Rheumatology #Lupus #MedTwitter

[Aravind Palraj @Rheumat_Aravind]

Anti-Sm antibody 🔍
• Highly specific — but not sensitive — for SLE
• Part of ENA panel (with RNP)
• Marker of disease classification rather than activity
• Often linked with anti-RNP overlap (MCTD spectrum)
• Low prevalence in Europeans, higher in African ancestry
@DrAkhilX @IhabFathiSulima #MedTwitter #rheumatology

[Aravind Palraj @Rheumat_Aravind]

🔬 Systemic sclerosis isn’t one disease — it’s a spectrum.
Autoantibodies not only define the subtype but also predict organ risks.
Know your antibody → anticipate the complication.
#Rheumatology #MedTwitter #SystemicSclerosis @DrAkhilX @IhabFathiSulima

[Aravind Palraj @Rheumat_Aravind]

Autoimmune Hepatitis (AIH) — a rheumatology-hepatology bridge disease.
🔹 Common in young women
🔹 Labs: ↑AST/ALT, ↑IgG
🔹 Antibodies: ANA, SMA, anti-LKM1
🔹 Strongly linked with other autoimmune diseases (thyroiditis, SLE, RA, celiac)

Early diagnosis = reversible with steroids.
Delay = progressive fibrosis → cirrhosis.
@DrAkhilX @IhabFathiSulima
#Rheumatology #Hepatology #AutoimmuneHepatitis

[Aravind Palraj @Rheumat_Aravind]

🧬 Anti-CarP antibodies in RA
🔹 Autoantibodies to carbamylated proteins
🔹 Found in ~30–40% of RA; also in some seronegative cases
🔹 Linked with severe & erosive disease
🔹 Appear before onset, predict progression
🔹 Lower sensitivity vs ACPA → complementary biomarker
@DrAkhilX @IhabFathiSulima
#RheumTwitter #MedEd #RA

[Aravind Palraj @Rheumat_Aravind]

🚨 CAR-T in Autoimmune Disease – 2025 Updates
From NEJM, Lancet Rheumatology, Front Immunol & Nature:
1️⃣ Remission in refractory SLE & other AI diseases
2️⃣ Immune “reset” after B-cell depletion
3️⃣ LICATS: new organ-specific toxicity
4️⃣ Safety & scalability challenges
5️⃣ Early allogeneic CAR-T signals
@DrAkhilX @IhabFathiSulima @CelestinoGutirr @CMEINDIA1 @DurgaPrasannaM1
#Rheumatology #CAR-T #Autoimmune

[Aravind Palraj @Rheumat_Aravind]

Beyond the antibodies - the clinical story of APS matters most.
Think clot + miscarriage + positive aPL = time to suspect Antiphospholipid Syndrome.
@DrAkhilX @IhabFathiSulima @APSFA
#Lupus #APS #Rheumatology