#Antiphospholipid antibodies and #cardiovascular#thrombosis, now in @NatRevCardiol 👇:
https://t.co/JuVuLs3s16
Systematic summary across various conditions. In some cases, we challenge the old conventional thinking...
Truly multidisciplinary, led by our 🌟fellow @SinaRsh
FDA has granted Fast Track designation to J&Js nipocalimab for use in #SLE based on the results of a Phase 2b JASMINE study in which nipocalimab demonstrated reduction in lupus disease activity and potential for steroid sparing https://t.co/puQN6ecScj
ICE was LITERALLY arresting a child sex offender when these protesters tried to stop it.
At what point does the Left examine themselves and go “Okay, maybe WE ARE the bad guys?"
Anti-mitochondrial M2 Ab (AMA-M2) in 987 IIM pts-- 55 (6%) were AMA-M2 positive. AMA-M2+ had signif. higher rates of polymyositis (56% vs 23.5%), GGT, alk phos levels, & 3 fold more cardiac involvement (60 vs 13%) (arrhythmias, CHF, pulm HTN (31-56%), but no effect on survival https://t.co/YFojfbXEAY
Low-titre ANA is frequently overinterpreted.
• Seen in up to 20–30% of healthy adults
• Often benign and transient
• ANA is a screening test, not a diagnosis
A major pitfall:
Mislabeling low-titre ANA positivity as lupus in asymptomatic young women.
Clinical context > lab reports.
Reassurance is often correct care.
#Rheumatology #MedEd #ANA #MedTwitter @DrAkhilX @Janetbirdope@IhabFathiSulima #ClinicalReasoning #InternalMedicine
🚨 Here is the full 42 minutes of my crew and I exposing Minnesota fraud, this might be my most important work yet. We uncovered over $110,000,000 in ONE day. Like it and share it around like wildfire! Its time to hold these corrupt politicians and fraudsters accountable
We ALL work way too hard and pay too much in taxes for this to be happening, the fraud must be stopped.
A high ANA titer (≥1:640) in individuals without an autoimmune disease was found to be strongly associated with liver-related disorders, including nonalcoholic and alcoholic liver disease
Arthritis Care & Research
https://t.co/tkMpPFPnhc
Anti-CCP vs RF in suspected RA:
RF is older and less specific; false positives occur with infections, cryoglobulinemia, liver disease, and in the elderly.
Anti-CCP is highly specific and predicts erosive disease.
Best practice: order both and interpret with the clinical picture.
@DrAkhilX @IhabFathiSulima
#Rheumatology #RA #MedTwitter
🔬 Anti-dsDNA: Not just specific for SLE, but a direct clue to flare risk — especially lupus nephritis.
📈 Rising dsDNA + falling C3/C4? Think renal flare!
Consistent monitoring is key; trends matter more than single results.
@DrAkhilX @IhabFathiSulima@CelestinoGutirr #Rheumatology #Lupus #MedTwitter
Anti-Sm antibody 🔍
• Highly specific — but not sensitive — for SLE
• Part of ENA panel (with RNP)
• Marker of disease classification rather than activity
• Often linked with anti-RNP overlap (MCTD spectrum)
• Low prevalence in Europeans, higher in African ancestry
@DrAkhilX @IhabFathiSulima #MedTwitter #rheumatology
🔬 Systemic sclerosis isn’t one disease — it’s a spectrum.
Autoantibodies not only define the subtype but also predict organ risks.
Know your antibody → anticipate the complication.
#Rheumatology#MedTwitter#SystemicSclerosis @DrAkhilX @IhabFathiSulima
🧬 Anti-CarP antibodies in RA
🔹 Autoantibodies to carbamylated proteins
🔹 Found in ~30–40% of RA; also in some seronegative cases
🔹 Linked with severe & erosive disease
🔹 Appear before onset, predict progression
🔹 Lower sensitivity vs ACPA → complementary biomarker
@DrAkhilX @IhabFathiSulima
#RheumTwitter #MedEd #RA
Beyond the antibodies - the clinical story of APS matters most.
Think clot + miscarriage + positive aPL = time to suspect Antiphospholipid Syndrome.
@DrAkhilX @IhabFathiSulima@APSFA#Lupus#APS#Rheumatology