APS Foundation of America

APS Foundation of America (#APSFA) is the only US org spreading #Antiphospholipid Syndrome #APS & #Lupus #Awareness! #DVT #PE #Stroke #APS #miscarriage

[APS Foundation of America @APSFA]

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[The Rowan Foundation @alexrowanfound]

June is APS Awareness Month.

APS is an autoimmune condition that can increase the risk for dangerous blood clots and affect women’s health decisions across birth control, pregnancy, and menopause.

In this Rowan Foundation feature, Tina Pohlman, @APSFA, and Sara Wyen, @ClotRecoveryNet, share insights from their lived experiences and advocacy efforts.

Read more: https://t.co/G1pjgwxgxH

[APS Foundation of America @APSFA]

@Ennan_D @DrAyubaD 6 DVTs one has never been done, never

[APS Foundation of America @APSFA]

@Ennan_D B. Ultrasound

[APS Foundation of America @APSFA]

@Sage_medics Skin

[APS Foundation of America @APSFA]

@ChShafiullah15 Type O

[Aravind Palraj @Rheumat_Aravind]

VASCULITIS MIMICS

Not every purpura is vasculitis.

Before labeling a patient as having primary vasculitis and initiating immunosuppression, consider important mimics such as infective endocarditis, cholesterol embolization syndrome, antiphospholipid syndrome, thrombotic microangiopathy, calciphylaxis, atrial myxoma, fibromuscular dysplasia, levamisole-associated vasculopathy, septic emboli, and malignancy-associated vasculitis-like syndromes.

Recognizing the red flags can prevent diagnostic errors, unnecessary immunosuppression, and potentially life-threatening consequences.

Which vasculitis mimic have you found most challenging in clinical practice?

Infographic by Dr. Aravind Palraj

#Rheumatology #Vasculitis #ANCA #MedicalEducation #MedEd #FOAMed #InternalMedicine #Nephrology #ClinicalReasoning @IhabFathiSulima @docakx #AutoimmuneDisease #MedTwitter #RheumTwitter #MedX #Medicine #MedEdCommunity

[Alberto Giraldo @alb_giraldo]

📅 World Antiphospholipid Syndrome (APS) Awareness Day is observed annually on June 9th. The day was established by the APS Foundation of America (APSFA) in 2010 to mark their fifth anniversary and spark global dialogue about this systemic autoimmune disorder.

APS was first described in 1983 by British rheumatologist Dr. Graham R.V. Hughes and his team at St. Thomas' Hospital in London.

Prior to 1983, the "lupus anticoagulant" was primarily known as a curious laboratory finding in patients with systemic lupus erythematosus. Hughes and his colleagues identified that these circulating antibodies (and their associated false-positive syphilis tests) were tied to a specific and devastating clinical triad:
𝟭. 𝗧𝗵𝗿𝗼𝗺𝗯𝗼𝘀𝗶𝘀:Recurrent blood clots (both arterial and venous).
𝟮. 𝗢𝗯𝘀𝘁𝗲𝘁𝗿𝗶𝗰𝗮𝗹 𝗖𝗼𝗺𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀: Unexplained, recurrent miscarriages and fetal loss.
𝟯. 𝗡𝗲𝘂𝗿𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗗𝗶𝘀𝗲𝗮𝘀𝗲: Conditions like stroke and epilepsy.

Dr. Hughes published these landmark observations in the British Medical Journal in October 1983, initially dubbing the triad "Thrombosis, abortion, cerebral disease, and the lupus anticoagulant". The disorder was later commonly named Hughes syndrome in his honor.

𝗞𝗲𝘆 𝗛𝗶𝘀𝘁𝗼𝗿𝗶𝗰𝗮𝗹 𝗠𝗶𝗹𝗲𝘀𝘁𝗼𝗻𝗲𝘀
◦ 𝙄𝙢𝙢𝙪𝙣𝙤𝙖𝙨𝙨𝙖𝙮 (𝟭𝟵𝟴𝟯): Researchers E. Nigel Harris and Aziz Gharavi, working in Hughes' laboratory, developed the anticardiolipin assay (ELISA), allowing for accurate testing of the antibodies.
◦ 𝙋𝙧𝙞𝙢𝙖𝙧𝙮 𝘼𝙋𝙎 (𝟭𝟵𝟴𝟴): Dr. Ronald Asherson highlighted that the syndrome could occur in patients without underlying lupus, officially classifying it as Primary Antiphospholipid Syndrome.

📸 Dr. Graham Robert Vivian Hughes, renowned British rheumatologist, honorary member of the American Lupus Hall of Fame and doctor honoris causa from the universities of Marseille and Barcelona / 🧾 Boey ML, Colaco CB, Gharavi AE, Elkon KB, Loizou S, Hughes GR. Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant. Br Med J (Clin Res Ed). 1983;287(6398):1021-1023.
🔗https://t.co/ZlHZ3ss2Bo

[APS Foundation of America @APSFA]

@suhail_nasfr5w Spleen

[APS Foundation of America @APSFA]

@Rheumat_Aravind @docakx @DocPriyamMD @DrNikhilMD @IhabFathiSulima Warfarin.

[APS Foundation of America @APSFA]

@pathdoc3 @grok Very much old news

[APS Foundation of America @APSFA]

Thank you so much for the immeasurably valuable work you have done for our community.

We at the APS Foundation of America want to let you know that your dedication is essential to the work that we do. You help us ensure that we are meeting our mission.

[Laurent ARNAUD @Lupusreference]

✅ Now that #LupusGPT is published in the Lancet #Rheumatology (LINK: https://t.co/Xqr1mPkHZp), I wonder whether you have previously tested the app itself. Ask it anything about #lupus, in any language and tell me what you think: https://t.co/Qob1EunPPL

[pathdoc3 @pathdoc3]

🤯

[pathdoc3 @pathdoc3]

🧐 “Anti-C1q Antibody and Antiphospholipid Antibodies Jointly Predict Thrombosis in Membranous Lupus Nephritis: A Retrospective Cohort Study” @APSFA #SLE 🦋

https://t.co/Hiq3jIp99m

[APS Foundation of America @APSFA]

Thank you so much for the immeasurably valuable work you have done for our community.

We at the APS Foundation of America want to let you know that your dedication is essential to the work that we do. You help us ensure that we are meeting our mission.

[APS Foundation of America @APSFA]

@Lupusreference @LupusEurope Example

[APS Foundation of America @APSFA]

@bbikdeli @JerroldLevy @NatRevCardiol @MGBResearchNews Such a complex mess #APS is as we know