Fagan Lab at the University of Sheffield

We are the Clostridial Cell Biology Group at the University of Sheffield
@sheffielduni @MM_Sheffield
Clostridial cell biology & phage structure and function.

[Andrew Preston @apreston243]

New paper alert! A toolbox of genetic tools for use in Clostridia, made available to the community. @MicrobioSoc @RobFagan https://t.co/JdYqhtdTiu

[Fagan Lab at the University of Sheffield @RobFagan]

🚨 Fully funded PhD studentships 🚨 We have 3 fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss

[Fagan Lab at the University of Sheffield @RobFagan]

Project 3: Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile.

https://t.co/inUqeiMp9W

[Fagan Lab at the University of Sheffield @RobFagan]

🚨 Fully funded PhD studentships 🚨 We have 3 fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss

[Fagan Lab at the University of Sheffield @RobFagan]

Project 2: Doubling down: determining the dual function of VanT in C. difficile antibiotic resistance.

https://t.co/JotkIpjT6X

[Fagan Lab at the University of Sheffield @RobFagan]

More info on the MSCA schemes here:
https://t.co/dncYfULb3I
and you can see a few of our current projects here:
https://t.co/6IrZGzScdy

[Fagan Lab at the University of Sheffield @RobFagan]

The 2025 round of the MSCA Postdoc Fellowships launches soon, with a deadline of September 10th. If you're interested in Clostridial cell biology and looking for a host lab for your fellowship please get in touch to discuss possible projects

[Fagan Lab at the University of Sheffield @RobFagan]

The Marie Skłodowska-Curie Actions Fellowships support applicants up to 8 years post-PhD from anywhere in the world who want to spend 1-2 years working in Europe (incl. UK!). These can be a fantastic stepping stone to longer term fellowships and establishing independence

[Fagan Lab at the University of Sheffield @RobFagan]

There is still a huge amount of work to do but this is a fascinating first look at an S-layer penetrating phage!

[Fagan Lab at the University of Sheffield @RobFagan]

New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance

[Fagan Lab at the University of Sheffield @RobFagan]

Interestingly the tail contracts less than in other characterised phages (& related contractile structures). This seems to be a feature of phage infecting bacteria that have an S-layer - given that these are likely the majority of bacteria, this is probably really common

[Fagan Lab at the University of Sheffield @RobFagan]

@lizopawoye @ellieevolves Potentially yes - please see the details below
https://t.co/0xbHhx4Dkv

[Fagan Lab at the University of Sheffield @RobFagan]

The 2nd round of our Yorkshire Biosciences PhD programme is now open for applications - deadline March 14th. Both of our C. diff phage projects are also available in this round - details in the thread below.

More info and expressions of interest here:
https://t.co/6SiwWk7YOP

[Fagan Lab at the University of Sheffield @RobFagan]

We have 2 fully funded PhD studentships available through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on #phage that infect #Cdifficile

[Fagan Lab at the University of Sheffield @RobFagan]

The 2nd round of our Yorkshire Biosciences PhD programme is now open for applications - deadline March 14th. Both of our C. diff phage projects are also available in this round - details in the thread below.

More info and expressions of interest here:
https://t.co/6SiwWk7YOP

[Dr. Ellie Harrison @ellieevolves]

No2...Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile with @RobFagan https://t.co/Bo8IcVlhbK #microbialevolution #pathogenevolution #PhDposition

[Dr. Ellie Harrison @ellieevolves]

PhDs avaliable in the lab! No1....what are rhizobia up to OUTSIDE the symbiosis? https://t.co/wd9YfptMag with Prof Tim Daniell. Come along to our project info session Tues 10th at 2pm. register here https://t.co/kWLsCx2Ztl #microbialevolution #symbiosis #PhDposition