Robyn Kosinsky

[Dominik Saul @dominiksaul88]

Check out our commentary on spatial transcriptomics published in Clinical and Translational
Medicine (https://t.co/HzVqCYkpng) . This methods allows us to analyze gene expression patterns in a tissue sample while preserving spatial information

[Dominik Saul @dominiksaul88]

An old bisphosphate friend may help to alleviate the burden of senescence: Samakkarnthai et al. demonstrate this in vitro and in vivo https://t.co/jmOg2RTjAr @Samakkarnthai @MayoClinic @skhosla78 @MadisonDoolitt3 @sfeirjad @Japneet__Kaur_ @NKLeBRASSEUR @aging #bone #aging

[Dominik Saul @dominiksaul88]

What happens if you remove senescent cells from bone locally as compared to systemic senolysis? Amazing work by Farr and the Khosla Lab:

JCI - Local senolysis in aged mice only partially replicates the benefits of systemic senolysis https://t.co/hLd4eHzhng @jclinicalinvest

[Gui Ramos MD @GuiRamosMD]

🚨In this month’s edition of @AGA_Gastro our group @FaubionWilliam Lab, shows how inhibitors of the epigenetic enzyme G9a can metabolic reprogram Tcells into Treg capable of controlling Intestinal Inflammation.

Cell engineering & Epigenetic Modulation as potential novel #IBD txs

[Dominik Saul @dominiksaul88]

Ever wondered why some bones 🦴do not heal? We outline answers from basic research and the clinic:

Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors https://t.co/9mfjMSK2IL

[Dominik Saul @dominiksaul88]

Awesome presentation by @skhosla78 on fracture healing and the impact of p21-driven cellular senescence at @ASBMR #ASBMR2022,thanks to @MadisonDoolitt3 @Japneet__Kaur_ @RobynKosinsky and the KhoslaLab #fracture #bonehealing #aging #senescence #science #research #bone @MayoClinic

[Dominik Saul @dominiksaul88]

Do you want to detect senescent cells in your sequencing dataset? Or monitor your senolytic therapy?
SenMayo can help you: https://t.co/AapjSJGMbp @natcomms #senescence #aging #research #SASP #Bioinformatics @NextGenSequence @skhosla78 @MadisonDoolitt3 @RobynKosinsky @PassosLab

[Dominik Saul @dominiksaul88]

Doolittle et al. use a new ERαΔOcy mouse model to decipher the mechanism of ERα action in bone:
Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice https://t.co/MuwPOYIYuC
#bone #jbmr #estrogen @skhosla78 @MadisonDoolitt3 @Japneet__Kaur_ @MegVoda

[Robyn Kosinsky @RobynKosinsky]

@DS8874945102 @OrthoToday @MayoClinicEndo @MayoClinic @skhosla78 Congratulations!

[Dominik Saul @dominiksaul88]

Check out our review in #EndocrineReviews:
Fracture healing and how it is affected by endocrine diseases, aging, and cellular senescence:
https://t.co/krxndVnweM
#fracture #Healing #bonehealing #bone #aging #senescence @OrthoToday @MayoClinicEndo @MayoClinic @skhosla78

[Fabian Theis @fabian_theis]

Interested in spatial omics? Plz check out our squidpy tool, bringing together omics & image analysis to enable a scalable description of spatial molecular data. Out today @naturemethods thx to @g_palla1, @HannahSpitzer1 & team! https://t.co/0iD92imm4H https://t.co/VPpelQHzl1

[nature @Nature]

Inflammation in the gut is encoded by neurons in the brain https://t.co/7iOF6hkt96

[Dominik Saul @dominiksaul88]

Senescence is more than just p16 and p21: We developed an in silico approach to reveal cells high in the SASP. SenMayo🧑‍🔬
https://t.co/s1UuEwef4G
#aging #senescence @MayoClinic @SingleCellMedia @scell_papers @skhosla78 @MadisonDoolitt3

[Dominik Saul @dominiksaul88]

We linked aging to cancer on a single cell level:
Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations 🧬🥼https://t.co/uTYywynzwg #mdpicells #aging #Cancer @scell_papers @ScPapers @MayoClinic

[Dominik Saul @dominiksaul88]

Happy to share our latest work about CRP in primary hip arthroplasty:
https://t.co/cgUbFvJPcc #mdpijcm via @JCM_MDPI
Here we develop an algorithm predicting an early infection after hip arthroplasty at day 5 with a sensitivity of 87.5% 🧐💪
#orthotwitter #surgery #CRP #infection

[Robyn Kosinsky @RobynKosinsky]

@DS8874945102 @eLife @skhosla78 Congratulations!

[Dominik Saul @dominiksaul88]

Very happy that our eLIFE paper is finally out:
We demonstrate for the first time that senescent cells accumulate in the fracture callus. Their clearance improves bone healing.
https://t.co/wZhgYSW90U @eLife
#khoslalab #bonehealing #fracture #mayo #orthotwitter @skhosla78

[Robyn Kosinsky @RobynKosinsky]

@DS8874945102 @ASBMR @MayoClinicEndo @MayoClinic @uniGoettingen @MadisonDoolitt3 Congratulations!!! 🎈