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currently thinking about FinTech innovation. Views are my own. She/Her

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beautiful way to start your morning. tw: #Human "it's rough trying to divide not enough by too much. But what if one of the main things someone needed, we had all along?"

[Kimberly D. Manning, MD, MACP @gradydoctor]

1/
Grady Hospital

Him: "I like the way you look at me."
Me: "Excuse me, sir?"
Him: "I mean. . . I like how your eyes look at me."

His words caught me off guard. I’d only been there a few moments. It seemed misplaced.

Me: "I want to receive that. Tell me what you mean, sir."

[BAY AREA STATE OF MIND @YayAreaNews]

An Earthquake just struck the Bay Area

Did you feel it?

[່ @tylerduran21]

@AdamDeats here’s the full south park episode for those interested

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#NewsWeNeed

[Nature is Amazing ☘️ @AMAZlNGNATURE]

In Dagestan, a hedgehog approached a passerby so that he could remove the tape from its paw. News we lack

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Would you miss me in the end when I run out of oxygen? "Run Away to Mars" https://t.co/os5cInCQIY

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💔

“Feel Good (Version Acoustique)" by Charlotte Cardin on Amazon Music. https://t.co/2sPGswQPic

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Eff.

[Outbreak Updates @outbreakupdates]

H5N1 - NEW AGGRESSIVE STRAIN

A new strain of bird flu has been detected in Iowa.

"This is a separate wild bird strain," Naig says. "It's not the dairy strain, and it's not the previous poultry strain. So, it's new and it's quite aggressive."

Mike Naig is the state's Agriculture Secretary, and he says they're expecting more.

[Outbreak Updates @outbreakupdates]

An H5N1 case in an Alameda County child raises red flags.

Why test a child with “mild” symptoms, especially when no routine surveillance is mentioned?

The entire family had respiratory symptoms.

Was the child part of a cluster?

1/

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💀

[K-in-CT 😷😷😷 @KinCONN]

#H5N1 @CDCgov @USDA @CAPublicHealth
⚠️🚨⚠️
There are a few problems with this #H5N1 case in a child in Alameda County, CA.

What strikes me is that CDPH has held onto this rather critical information for many days. That is *not* best practice when trying to avert a pandemic.

CDPH must have some reason, some additional concerns (beyond the obvious), to slow walk this to the extent that they did.

A very important open question: why did they decide to test the child for #H5N1? Why?

They do **not** say that the child's case was picked up on routine surveillance. They would say that if they could.

And if the child's symptoms were indeed "mild," why even test him or her? Many, many, kids are bringing home all sorts of muck on the regular from day care, from school, in the month of November.

The family is in Alameda County, near San Francisco. Not big dairy land due to the cost of real estate.

So why did CDPH even test this child for #H5N1?

CDPH is looking for a wild bird connection.
I would not just be looking for wild birds - sure, maybe the child visited a local park or the seaside.

Maybe CDPH has initial sequencing in hand and knows it's D1.1 (the avian strain)? If it is, I'd be curious to learn if it exhibits any passaging through other humans/mammals before finding the child.

I'd also be looking at who at that day care had been sick in the days *prior* to the child's illness onset. With light symptoms that were light enough to still send a child to school (same for the teachers).

The child's family *all* had similar respiratory symptoms but they were likely not tested until the child returned a positive.

The family members may have transferred the virus to the child - they may have been infected prior to the child, but their cases may have been on the way to resolution by the time the child was tested, and certainly by the time they were tested, if symptoms for all were indeed mild.

They really, really, really, don't want a human #H5N1 cluster that has no animal or bird connection. Even one with "mild" symptoms. They really don't.

CDPH is dismissing the symptoms in the others (and in the child - for whom there is no mention of conjunctivitis) by saying there was a respiratory "co-infection," and we can only hope that it was not a co-infection with a seasonal flu strain. (They don't specify what virus it was that caused the issues).

Everybody's gotten Tamiflu. The antiviral appropriately rendered the child negative upon retest four days after the first positive test.

They state that the child had a "low level" of virus, but I have many, many, questions about how people are being sampled, and when.

The "low level" of virus is signaling that we may not get complete sequence data.

Since it's been a week, why hasn't the sequence data yet become available for this very important human #H5N1 case?

It will be important to learn at least whether this clade is B3.13 (bovine) or D1.1 (avian).

And, I'll ask again, **why** was this child tested for #H5N1?

[Snow Lee @snow_w_lee]

I’m at @TechCrunch Disrupt! Meeting great founders and learning about startups is always exciting. Anyone at the #TechCrunchDisrupt 2024? Let’s connect!

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Live now at Breakout stage 2! How @CitiVentures helps catalyze #Innovation at @Citi by investing in and partnering with category defining companies such as @quantifind 🙌🏽 #CitiRetailServices
#TechCrunchDisrupt

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“Yes she can.” #PresidentKamalaHarris

[Barack Obama @BarackObama]

What I admire most about Joe is his decency, his resilience, and his unshakable belief in the promise of our country. Over the last four years, those are the values America has needed most. I am proud to call him my president, and I’m so grateful to call him my friend.

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VCs don’t know creative? Pff. #Beg2Differ https://t.co/3jNFGZKuzE

[Chamath Palihapitiya @chamath]

Every day we are bombarded with so much news about AI that it's increasingly difficult to know what is signal and what is noise. And the tidal wave of this information came so quickly that for many, including myself, there was never a moment to take a step back and learn the basics in a way that put everything into context.

As a result, I found myself with a brittle understanding of AI and often nodding in agreement about something in the space that I didn’t quite understand.

So we set out to write a primer on AI like we did last month on energy transition. Assuming you had no prior knowledge, we wanted to create a document that was easy to read and understand. Where you could jump in and out of any section. And where the content was evergreen so you could refer to it as needed - today or in the future.

To that end, this month’s Deep Dive aims to provide an intuitive foundation on artificial intelligence, covering how it works, what the different types of models are, this current wave of generative AI and our path to achieving AGI. You can read this today on my Substack (link in bio).

In future months, I will publish deep dives into other sectors of the economy that I think are important to understanding the world today. These fall into five themes:

1. Deep Tech
2. Energy Transition
3. Healthcare & Life Sciences
4. Economic Analysis
5. Socio-Political Trends

If enough people care about this and continue to subscribe, not only can we invest to hire more researchers, we will also look to you, our subscribers, to influence what we research and read out to everyone in the future.

I hope you enjoy reading this and let us know how we can improve.

Disclaimer: The views and opinions expressed above are current as of the date of this document and are subject to change without notice. Materials referenced above will be provided for educational purposes only. None of the above will include investment advice, a recommendation or an offer to sell, or a solicitation of an offer to buy, any securities or investment products.

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Welp.

[OpenAI @OpenAI]

ChatGPT can now browse the internet to provide you with current and authoritative information, complete with direct links to sources. It is no longer limited to data before September 2021.

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🎧 Spun by REZZ on @PandoraMusic
https://t.co/IAPtinjW9u #Mood

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Money may not buy happiness, but it sure makes it more affordable. #Facts #MidnightMusings

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great #ProductoftheFuture ideas for practically everything.

[GREG ISENBERG @gregisenberg]

The future of building startups:

- MVP speed (1x per month)
- AI-accelerated
- Superniche is the new niche
- Community 1st, software 2nd
- No-code 1st, some code 2nd
- 10x more automated
- Global teams, localized products
- 95% dominated by solopreneurs and microentrepreneurs (teams less than 12)
- Pop-up digital experiences (apps that only work on certain times)
- Needs the marketing holy-trinity to hit escape velocity: 1. product/market fit, 2. content/market fit and 3. community/market fit
- Team is half robots 🤖, half humans 👨‍🦰 (cc @youneedarobot)
- Accelerated by "boring marketing" (cc @boringmarketer)
- Multiple revenue streams
- Design matters. The bar is high
- Partnered w/ creators (creators are the distribution)
- Feels like a game (levels, status, badges, in-app currency, challenges, collectibles/items)
- Purpose-driven moonshots: societal impact matters
- Productized agencies to generate cashflow (ex design agency @DispatchDesign)
- Product studios become the norm
- 99% of MVPs won't need VC

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Thunberg dictating 2023 energy

[Greta Thunberg @GretaThunberg]

yes, please do enlighten me. email me at [email protected]

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Ready. Set. And go #2023

[DAN KOE @thedankoe]

How to do a hard reset on your life (in 30 minutes):

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For. The. Win. 🙌🏽 https://t.co/U5q67GCv9C