Happy July 4th!
Celebrating 250 Years of American Independence.
This Independence Day, take charge of your health. Get tested. Know your numbers. https://t.co/PEMYPtPgLd
Consistency beats exercise intensity, hours or type.
Study of 143k people, at midlife, over 20 years, shows even small amount of resistance training, done consistently, can help lower the risk of diabetes significantly.
Source: https://t.co/4vKajOZEQ0 ; https://t.co/nubDBOdwdH
👉The “low cholesterol increases mortality” argument just took another hit.
☝️A new Danish population study spanning nearly 30 years found:
📍Median LDL-C fell from 142 to 124 mg/dL
📍Median non-HDL-C fell from 174 to 150 mg/dL
📍The LDL-C level associated with the lowest mortality shifted downward from 155 to 135 mg/dL
📍The non-HDL-C level associated with the lowest mortality shifted downward from 186 to 162 mg/dL
📍At the same time, overall mortality declined
📍Cardiovascular mortality declined substantially
👉Key takeaways
1️⃣ Lower population LDL-C did not lead to higher mortality.
2️⃣ The “optimal” LDL-C observed in epidemiological mortality curves is not a fixed biological constant.
3️⃣ Mortality nadirs move as populations become healthier, cardiovascular prevention improves, and LDL-C levels decline.
4️⃣ The well-known U-shaped association between LDL-C and mortality is likely driven, at least in part, by reverse causation and residual confounding at the low end.
5️⃣ These findings are fully consistent with the extensive genetic, epidemiological, and randomized trial evidence supporting LDL-C lowering for ASCVD prevention.
👉Bottom line
📍The question is not whether lowering LDL-C increases mortality.
📍This study suggests the opposite concern may have been misplaced all along:
📍As population LDL-C levels fell, mortality did not rise—it fell too.
🔓🔗 https://t.co/q3oniarrxR
@society_eas@ATHjournal@BNordestgaard
It has been called with many superlatives:
- Super hormone
- Mother of all hormones
- Youth hormone
- Fountain of youth
- Anti-aging agent
DHEA is a highly popular supplement & precursor of many hormones (T, E2).
But levels drop with age after 20's.
https://t.co/1DjIUMvv9u
For fatty liver, R-FACTOR identifies the type of injury to liver.
R=5+: hepatocellular, direct damage to liver cells (viral infection, alcohol, medication).
R=2-: cholestatic, blockage of bile duct (gallstones, less bile).
Input? a liver function test: https://t.co/AaR0fHWxLa
(8/8) Life's Essential 8™ : Sleep
What's the optimal amount of sleep?
Extensive research on 5,500 participants shows:
- 7-8 hours optimal
- 11 pm bedtime
- 6:30 am wakeup
Both short & long sleep hours increase blood pressure & risk of heart disease.
https://t.co/nubDBOdwdH
Although salt is necessary for taste & shelf-life, excess salt raises the blood pressure.
Research shows cutting down sodium from 1.5 tablespoon to half-a-spoon can lower blood pressure substantially.
https://t.co/nubDBOdwdH
(7/8) Life's Essential 8™ : Smoking
Direct & second-hand smoking (or vaping) has clear impact on heart health.
Smoking damages the blood vessels, causing inflammation & plaque, that lead to more clots & higher risk of strokes & heart diseases.
https://t.co/nubDBOdwdH
(6/8) Life's Essential 8™ : Blood Pressure (BP)
With age, plaque deposits stiffen & narrow the arteries, causing high BP & stress on the heart.
High BP is well known cause of heart diseases & values over 120/80 require regular monitoring or medication.
https://t.co/nubDBOdwdH
(5/8) Life's Essential 8™ : Cholesterol & Lipids
Non-HDL-cholesterol is one of the most critical markers of plaque deposit, which over time increases the risk of heart attack.
A lipid panel is the key to monitor this risk regularly.
https://t.co/nubDBOdwdH #cholesterol#LDL
(4/8) Life's Essential 8™ : BMI
Body Mass Index is a simplified metric of weight & body composition.
Despite criticism, it's widely used in research & clinics.
BMI also depends on body type & ancestry.
Sometimes waist size maybe better alternative.
https://t.co/nubDBOdwdH
KLOTHO gene is a marker of longevity & anti-aging.
Discovered in 1997, the VS-KL genetic mutations show premature aging in mice.
It may offer protection against dementia & Alzheimer's, especially for those carrying APOE4 genes.
Now, you can test for it: https://t.co/YmpWc6gpTK
(3/8) Life's Essential 8™ : Blood Glucose
A1c levels over 5.7% or a fasting glucose over 100 mg/dL indicate risk of current or future diabetes.
Another key risk factor: first-degree relatives with diabetes.
Guidelines by American Diabetes Association: https://t.co/fPPsOAqTI0
(2/8) Life's Essential 8™ : Exercise
Exercise has clear advantages for heart health:
- 150 min/week of moderate (100 steps/min; 75% of max heart rate) is recommended.
- Resistance training (& power breathing) can lower blood pressure by 5-10 mmHg.
Ref: https://t.co/daeo4BW7GH
♡ Life's Essential 8™ - The Key Markers of Heart Health in a Single Image:
Reference: https://t.co/BIYYuQPAJl 2026
JACC guidelines: https://t.co/DL54OwWNMF
Order a Lipids panel anytime: https://t.co/vrG0f7l8yc
(original image updated with Cholesterol below 200, not 100)
(1/8) DIET - as part of Life's Essential 8™
Multiple studies have shown diet has clear impact on improving heart health.
Small changes, such as diet rich in fruits, vegetables, nuts, low fat, lean meat alone can lower blood pressure by 5%.
https://t.co/lslAo65DUp #hearthealth
The American College of Cardiology's 2026 guidelines add 2 new heart markers:
Lipoprotein (a):
- depends on family history
- should be measured at least once in life
- over 50 mg/dL means 40% higher risk
ApoB:
- better marker than LDL for some people
https://t.co/vrG0f7l8yc
50 Years of the famous 'self-help' experiment that proved ulcers could be caused by H. pylori.
Barry Marshall, an Australian MD, proved that infection by Helicobacter pylori led to gastritis and peptic ulcer disease (& was given 2005 Nobel prize).
https://t.co/QIFC4Mpfcd
Metabolic Syndrome is very common (1 in 3 adults).
But it's extremely difficult to define.
Depending on who you talk to, there's a new definition.
However, insulin resistance is key, & it starts with body fat, which relates to the waist size with age.
https://t.co/vrG0f7l8yc
One-in-10 men is expected to test positive for prostate cancer during their lifetime.
(2nd most common after breast cancer).
However, survival rate is very high, especially after early diagnosis.
A PSA Screening Test after 50y is recommended by USPTF.
https://t.co/kbSQhgA8zI