Do you want to learn more about conferences that we co-organize outside of Switzerland? The report of the FiMC, co-organized by the SCS 🇨🇭and GDCh 🇩🇪, was published in ChemMedChem 💊🧬🧫
https://t.co/JjE3dRjVlQ
It’s hoped that the resulting agent, [18F]NP3-627, could enable the clinical development of drugs acting on the NLRP3 inflammasome, lead to a better understanding of their target engagement and optimal dose, and help stratify patients and monitor disease progression.
📯 Paper Alert 📯
A study published in @ChemMedChem describes the identification of a potential positron emission tomography (PET) imaging agent targeting the NLRP3 protein.
https://t.co/Mn0KZPjNhQ
@Novartis 🧫💊
Using pyridazine-based inhibitors as a starting point, the research team leveraged their improved permeability and brain-penetrant properties to develop imaging agents for NLRP3 that could help measure both target expression and occupancy by a drug in the CNS.
NP3-253 is expected to be a useful tool to further study NLRP3 inhibition, especially in the central nervous system (CNS) in neuroinflammatory conditions.
📯 Paper Altert 📯
In the Journal of Medicinal Chemistry, researchers from @Novartis describe the discovery, characterization, and optimization of a series of pyridazine-based NLRP3 inhibitors, including lead molecule NP3-253. 🧫💊
https://t.co/O8NKscGJdw
🏆 EFMC-YSN PhD Prize 2025 🏆 Applications are now open!
The EFMC-Young Scientists Network recognizes excellence by awarding a European PhD student in medicinal chemistry or chemical biology
🔗 Apply here: https://t.co/2qJJGrw2aQ
⏱️ Deadline: January 31, 2025
🚨#JobAlert🚨 Join us in Geneva @unige_en!
We have an open #postdoc position starting in 2025. If you are interested in studying chromatin regulation and working with brain organoids, apply now! #sciencejobs
More info: https://t.co/sX4ANFzRCu
Just a few days left (Oct 9) to submit your abstract for OC! Check the list of confirmed speakers and register to not miss your chance to be part of #EFMCISCB25! @EuroMedChem@SCS_DMCCB@YoungSciNet
🔥 We have two open full prof positions at our institute (LOC) at @ETH_DCHAB@ETH_en
1. Synthetic Organic Chemistry
2. (Bio)Analytical Chemistry
Apply until Nov 15 and be our colleague!
https://t.co/Nv9gV91KVm
Don’t miss your chance to be part of the #EFMCISCB25!Submit your abstract for an Oral or a Poster Communication by October 9 and showcase your research to a focused audience of Chemical Biologists and Medicinal Chemists.
https://t.co/Phc0gdVGau
🚨 Your Opinion Matters! 🚨
We’re gearing up for the Basel Symposium 2025, and we want YOU to help shape the event. 🗳️ Cast your vote now for the topic you’re most excited to explore on February 6, 2025 🌟
https://t.co/x8YeOysorI
This week on the front cover of ChemMedChem: Developing Low Molecular Weight PET and SPECT Imaging Agents
https://t.co/SJDikuoypJ
Congratulations on this outstanding work and the beautiful cover L. Xue, C.M.L. Jie, S. Desrayaud and @YvesAuberson from @NovartisScience in Basel!
⏰ The registration deadline for the Peptide Therapeutics Forum 2024 is approaching (this Friday!) 💊🧫🧬 Please join us for a fantastic day of peptide science in Basel on August 22 & 23!
https://t.co/7XQ6vHZTzQ
Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. https://t.co/w00YCwtBDj @UZH_Chemistry@Hartrampf_Lab
📢Good news! The program for the @SNE_ChemBio retreat on June 3-4, 2024, is now available! Join us to dive into enlightening sessions, hear from esteemed speakers, and enjoy the breathtaking scenery of Champèry, Valais
🗓️Check out the agenda here 👉 https://t.co/fW2IoU5zS3
🌸 The May edition of MedChemBioWatch is now available! Stay informed about the latest activities of EFMC, upcoming events and so much more... 🔗 https://t.co/9GKZ5rkHDw #MedChemBioWatch#EFMC#MedChem#ChemBio