Today's #LandmarkTrialFriday is on the ROSE trial! Published in 2019, this trial showed that early and continuous infusion of cisatracurium did not improve 90-day mortality in patients with ARDS when compared to usual care.
#LandmarkICUTrials#ICU#Pharmacy#clinicaltrials
Today's #LandmarkTrialFriday is on the CRASH-3 Trial. Building on the CRASH-2 trial, this trial showed that TXA reduced head injury related deaths when administered within 3 hours to those with mild to moderate head injury.
#LandmarkICUTrials#ICU#Pharmacy#clinicaltrials
Today's #PearloftheWeek is on dexmedetomidine!
If drug-induced fever from dexmedetomidine is suspected, it should be discontinued and the patient's temperature should be monitored until back to normal.
#RxPearls#Pharmacy#Dexmedetomidine#TwitteRx
Today's #LandmarkTrialFriday is on the MENDS2 trial, which showed that there was no difference in days alive without delirium or coma between dexmedetomidine and propofol when used in mechanically ventilated patients with sepsis.
#LandmarkICUTrials#ICU#Pharmacy#clinicaltrials
Today's #LandmarkTrialFriday is on the ATACH-II Trial. Published in 2016 in the NEJM, this trial showed that targeting a more intense blood pressure goal for ICH patients did not lead to a decrease in mortality or morbidity. #LandmarkICUTrials#ICU#Pharmacy#clinicaltrials
#PearloftheWeek is on fentanyl! Intravenous fentanyl can provide maximal analgesic effects within minutes and does not have active metabolites like morphine, making it safer in acute kidney injury.
#RxPearls#Pharmacy#Medicine
Todayβs trial is about the AID-ICU trial published in October 2022! Although these findings showed no statistical significance for the primary outcome, haloperidol is still used for this indication. #LandmarkTrialFriday#TwitteRx
Today's #LandmarkTrialFriday is about the NICE SUGAR Trial! Published in 2009 by Finfer et al, this trial showed that in ICU patients, conventional glycemic control with a blood glucose target of </= 180 mg/dL had lower mortality than patients with a target of 81-108 mg/dL.