Top Tweets for #OTILT

over 1 year ago

#otilt A single-dose liposomal amphotericin B combined with flucytosine and fluconazole is noninferior to the WHO-recommended multi-dose treatment for HIV-associated cryptococcal meningitis. @BWDionne @jeffpears0n @davidwkubiak https://t.co/nZ1Z84ldyM

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michelle lam @michelleslam48

over 1 year ago

#otilt Treatment for cryptococcal meningoencephalitis in HIV-infected individuals includes an induction phase with Amphotericin B and flucytosine for at least 2 weeks, then fluconazole for a minimum of 8 weeks. @BWDionne @jeffpears0n @davidwkubiak https://t.co/JCFJEwrRJP

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over 1 year ago

#OTILT Dexamethasone is used as adjunctive therapy in patients with bacterial meningitis since the subarachnoid space inflammatory response can be a major contributing factor to morbidity and mortality https://t.co/M3A2maarUC @BWDionne @jeffpears0n @davidwkubiak

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michelle lam @michelleslam48

over 1 year ago

#OTILT Drug reaction with eosinophilia and systemic symptoms (DRESS) is recognized as T-cell mediated and not antibody mediated https://t.co/uybbQoJbum @BWDionne @jeffpears0n @davidwkubiak

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over 1 year ago

#otilt No approved treatments exist for HHV-6; early therapy with intravenous ganciclovir or foscarnet is recommended, especially for encephalitis. @BWDionne @davidwkubiak @jeffpears0n https://t.co/9AeLjMGBYy

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over 1 year ago

#otilt Tazobactam is less effective at protecting β-lactams from AmpC hydrolysis than newer β- lactamase inhibitors, such as avibactam, relebactam, and vaborbactam. @BWDionne @davidwkubiak @jeffpears0n https://t.co/Du9LnsDOBv

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almost 2 years ago

#OTILT Candida glabrata exhibits intrinsically low susceptibility to azoles. Azole resistance is most commonly mediated by overexpression of drug-efflux transporter genes CgCDR1, CgCDR2, and CgSNQ2 through a gain-of-function mutation. https://t.co/pZYsj6g5xF.

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almost 2 years ago

#OTILT The PURPOSE-1 study showed that twice yearly lenacapavir injections are highly effective as PrEP in women. There were 0 cases of HIV in the lenacapavir arm compared to 16/1068 incident cases in the Truvada group and 39/2136 incident cases in the Descovy group.

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almost 2 years ago

#OTILT voriconazole has non-linear pharmacokinetics because of its capacity-limited CYP elimination. This requires dose increase to be made in smaller increments as it will show a super- proportional increase in AUC. https://t.co/WDDcpyEGxN

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almost 2 years ago

#OTILT Dalbavancin is used for its long half life that allows for less frequent dosing. Its long half-life may also prolong the mutant selection window and promote resistance and cross resistance to similar antibiotics like vancomycin or daptomycin. https://t.co/siOeLCvXCx

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almost 2 years ago

#OTILT Candida lusitaniae exhibits high intrinsic resistance to amphotericin B. Little is known about the resistance mechanism but it may be related to mutations in the ERG6 gene and reduced ergosterol production. https://t.co/gs7snxu2pg.

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almost 2 years ago

#OTILT while beta-D-glucan test can detect most fungi including candidia and aspergillus, it cannot be used for mucormycosis because mucormycetes have very low or absent beta-D-glucan production. https://t.co/2yL6AdwCoY

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almost 2 years ago

#OTILT letermovir is a relatively novel drug used for CMV prophylaxis in patients that undergo stem cell transplantation. It has shown to have lower risk for side effects that are commonly associated with other CMV prophylaxis agents like valganciclovir. https://t.co/WHueMVFJQ1

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almost 2 years ago

#OTILT One of the most common bacteria in cat bites is Pasteurella multocida, a gram negative microorganism which can be found in the oral cavity of cats. Amox/clav is the preferred treatment for most animal bites. https://t.co/zkS5rUsllN

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almost 2 years ago

#OTILT Although it's an AmpC beta-lactamase producing organism, Serratia marcescens is no longer considered to produce a clinically significant amount of AmpC beta-lactamase https://t.co/4UF4vrqOmr

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almost 2 years ago

#OTILT Intravesical gentamicin instillations effectively reduce the frequency of UTIs in patients with recurrent infections and reduces resistance rates of urinary tract pathogens. https://t.co/aDvkAYuIRj

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almost 2 years ago

#OTILT IVIG may cause false positives in (1-3)-B-D-glucan levels (BDG) within 3 weeks of its administration. This is due to the high levels of BDG in IVIG since cellulose-based membranes are used to prepare it. https://t.co/qkjYhCivKY

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almost 2 years ago

#OTILT In addition to antibiotic lock therapy, ethanol lock therapy is effective for preventing central line associated bloodstream infection (CLABSI) in patients with a central line. Although it's effective, it's not frequently used due to its risk of line degradation.

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