Stefan Ledinger

[Stefan Ledinger @SLedinger]

𝗧𝗿𝘆𝗽𝘁𝗼𝗽𝗵𝗮𝗻 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 𝗮𝗻𝗱 𝗮𝗿𝘆𝗹 𝗵𝘆𝗱𝗿𝗼𝗰𝗮𝗿𝗯𝗼𝗻 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 (𝗔𝗛𝗥): 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗳𝗼𝗿 𝗰𝗮𝗻𝗰𝗲𝗿, 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝗮𝗻𝗱 𝗮𝘂𝘁𝗼𝗶𝗺𝗺𝘂𝗻𝗲 𝗱?…https://t.co/EBCeo1uZwN

[Stefan Ledinger @SLedinger]

𝗣𝗼𝘀𝘁-𝘁𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗺𝗼𝗱𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗴𝗹𝘂𝗰𝗼𝘀𝗲 𝗮𝗻𝗱 𝗹𝗶𝗽𝗶𝗱 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺: 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗶𝗻 𝗰𝗮𝗿𝗱𝗶𝗼𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗮𝗻𝗱 𝗻𝗲𝘂𝗿𝗼𝗱𝗲𝗴𝗲?…https://t.co/nSDtSTisNY

[Stefan Ledinger @SLedinger]

𝗜𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗶𝗺𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝘁𝗵𝗲 𝗪𝗮𝗿𝗯𝘂𝗿𝗴 𝗮𝗻𝗱 𝗶𝗻𝘃𝗲𝗿𝘀𝗲 𝗪𝗮𝗿𝗯𝘂𝗿𝗴 𝗲𝗳𝗳𝗲𝗰𝘁
The Warburg effect has been known for a hundred years, but the situation is way more complex than what…https://t.co/FBYlv7dWoS

[Stefan Ledinger @SLedinger]

𝗖𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝗚𝗜𝗣𝗥/𝗚𝗟𝗣𝟭𝗥 𝗮𝗴𝗼𝗻𝗶𝘀𝗺 𝗮𝘁𝘁𝗲𝗻𝘂𝗮𝘁𝗲𝘀 𝗡𝗔𝗙𝗟𝗗 𝗽𝗮𝘁𝗵𝗼𝗴𝗲𝗻𝗲𝘀𝗶𝘀, 𝗹𝗲𝗮𝗱𝗶𝗻𝗴 𝘁𝗼 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗶𝗻 𝗳𝗮𝘁𝘁𝘆 𝗮𝗰𝗶𝗱, 𝗹𝗶𝗽𝗶𝗱 𝗮𝗻𝗱 𝘀𝘁𝗲𝗿𝗼𝗹 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺
There is…https://t.co/ZkMrzEcac8 https://t.co/1seFOnKBKF

[Stefan Ledinger @SLedinger]

𝗜𝘀 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀 𝗮 𝗴𝗮𝗺𝗲-𝗰𝗵𝗮𝗻𝗴𝗲𝗿 𝗶𝗻 𝘁𝗼𝘅𝗶𝗰𝗼𝗹𝗼𝗴𝘆?
We absolutely think so, but of course not every toxicologist has made equally good experiences with the technology. During my time in metabolomics,…https://t.co/VfQtgOKhCL https://t.co/etoesNeRZ1

[Stefan Ledinger @SLedinger]

𝗜𝗺𝗺𝘂𝗻𝗼𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 𝗶𝗻 𝗽𝗮𝘁𝗵𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝗼𝗳 𝗽𝘀𝗼𝗿𝗶𝗮𝘀𝗶𝘀
Like many (auto)immune diseases, psoriasis rates have risen in recent years - and as in other immune diseases, the role of metabolism has g…https://t.co/dPEEfGWoRW

[Stefan Ledinger @SLedinger]

𝗧𝘂𝗺𝗼𝗿-𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗲𝗱 𝗺𝗮𝗰𝗿𝗼𝗽𝗵𝗮𝗴𝗲 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺: 𝗺𝗲𝗱𝗶𝗮𝘁𝗼𝗿 𝗼𝗳 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 𝘁𝗵𝗲 𝘁𝘂𝗺𝗼𝗿 𝗺𝗶𝗰𝗿𝗼𝗲𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗻 𝗶𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿…https://t.co/VCvXEFVFSQ

[Stefan Ledinger @SLedinger]

𝗛𝗼𝘄 𝘁𝗼 𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗲 𝗖𝗔𝗥-𝗧 𝗰𝗲𝗹𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝘁𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴 𝗶𝗺𝗺𝘂𝗻𝗲 𝗰𝗲𝗹𝗹 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺?
Metabolism is hugely important for proper immune cell function. This is also true for "engineereed" immun…https://t.co/UWyMJxCAk7 https://t.co/NFw5xoIEG2

[Stefan Ledinger @SLedinger]

𝗠𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 𝗮𝘀 𝘁𝗮𝗿𝗴𝗲𝘁 𝗳𝗼𝗿 𝗮𝗻𝘁𝗶-𝗰𝗮𝗻𝗰𝗲𝗿 𝘁𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀
Previous posts on that topic suggest that many of you are quite interested in the role of mitochondria in disease and the possibilities to t…https://t.co/b8SRVEZSGt https://t.co/lrF8FITLua

[Stefan Ledinger @SLedinger]

𝗧𝗵𝗲 𝗴𝘂𝘁-𝗺𝘂𝘀𝗰𝗹𝗲 𝗮𝗰𝗶𝘀 𝗮𝘀 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗻 𝗗𝘂𝗰𝗵𝗲𝗻𝗻𝗲 𝗺𝘂𝘀𝗰𝘂𝗹𝗮𝗿 𝗱𝘆𝘀𝘁𝗿𝗼𝗽𝗵𝘆 A couple days ago, a novel gene therapy for Duchenne muscular dystrophy has been FDA approved, b…https://t.co/DJmigiAVSt https://t.co/NQJjM4WTOA

[Stefan Ledinger @SLedinger]

𝗡𝗔𝗗+, 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝗽𝗮𝘁𝗵𝘄𝗮𝘆𝘀 𝗮𝗻𝗱 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻: 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗳𝗼𝗿 𝗻𝗼𝘃𝗲𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 𝗶𝗻 𝗜𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝗕𝗼𝘄𝗲𝗹 𝗗𝗶𝘀𝗲𝗮𝘀𝗲𝘀 (𝗜𝗕𝗗)
Nicotinamide adenine dinu…https://t.co/a8tPeqXG8A https://t.co/i5eeYQ90NI

[Stefan Ledinger @SLedinger]

𝗗𝗶𝗿𝗲𝗰𝘁 𝗮𝗻𝗱 𝗶𝗻𝗱𝗶𝗿𝗲𝗰𝘁 𝗲𝗳𝗳𝗲𝗰𝘁𝘀 𝗼𝗳 𝗺𝗲𝘁𝗳𝗼𝗿𝗺𝗶𝗻 𝗼𝗻 𝗰𝗮𝗻𝗰𝗲𝗿 𝗵𝗮𝗹𝗹𝗺𝗮𝗿𝗸𝘀
Metformin has long been known to have pleiotropic effects. Also, I have been saying before that one ought to not only look at direct effects o…https://t.co/01mYyQ2KcF

[Stefan Ledinger @SLedinger]

🥑 𝗞𝗲𝘁𝗼𝗴𝗲𝗻𝗶𝗰 𝗱𝗶𝗲𝘁 𝗮𝗻𝗱 𝗰𝗮𝗻𝗰𝗲𝗿: 𝗯𝗲𝗻𝗲𝗳𝗶𝗰𝗶𝗮𝗹 𝗼𝗿 𝗱𝗲𝘁𝗿𝗶𝗺𝗲𝗻𝘁𝗮𝗹? 🥑
Cancer patients are naturally curious about what they could do lifestyle-wise to help them fight the disease and ketogenic die…https://t.co/jXfdzFHSrp https://t.co/N5fL98uEM3

[Stefan Ledinger @SLedinger]

𝗦𝘁𝗮𝘁𝗶𝘀𝘁𝗶𝗰𝘀 𝗿𝗲𝘀𝗼𝘂𝗿𝗰𝗲𝘀 𝗳𝗼𝗿 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗶𝗻 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀
Metabolomics is a powerful tool for biomarker discovery, but statistics and interpretation can be a bottle neck. Also, not only the choice…https://t.co/itlS5Yuo90

[Stefan Ledinger @SLedinger]

𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀 𝗮𝘀 𝗮 𝘁𝗼𝗼𝗹 𝘁𝗼 𝘀𝘁𝘂𝗱𝘆 𝗱𝗿𝘂𝗴 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻𝘀
(𝗱𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗱𝗿𝘂𝗴𝘀 𝗮𝗻𝗱 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝗳𝗹𝘂 𝘃𝗮𝗰𝗰𝗶𝗻𝗲)
Would you think that the treatments that you take for other causes affect respons…https://t.co/2L3YioOvXm

[Stefan Ledinger @SLedinger]

𝗣𝗲𝗿𝘀𝗼𝗻𝗮𝗹𝗶𝘇𝗶𝗻𝗴 𝗶𝗻𝘁𝗲𝗿𝘃𝗲𝗻𝘁𝗶𝗼𝗻𝘀 𝘁𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 𝗵𝗲𝗮𝗹𝘁𝗵: 𝘁𝗵𝗲 𝗿𝗼𝗹𝗲 𝗼𝗳 𝗼𝗺𝗶𝗰𝘀 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀 𝗮𝗻𝗱 𝗺𝗼𝗱𝗲𝗹 𝘀𝘆𝘀𝘁𝗲𝗺𝘀
Is there any major disease that the microbiome hasn't bee…https://t.co/wWMsVAFvfL

[Stefan Ledinger @SLedinger]

𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿 𝘆𝗼𝘂𝗿𝘀𝗲𝗹𝗳 𝗮𝘀 𝗮 𝗯𝗹𝗼𝗼𝗱, 𝗽𝗹𝗮𝘀𝗺𝗮 𝗮𝗻𝗱 𝘀𝘁𝗲𝗺 𝗰𝗲𝗹𝗹 𝗱𝗼𝗻𝗼𝗿 - 𝗶𝘁'𝘀 𝘀𝗶𝗺𝗽𝗹𝗲 𝗮𝗻𝗱 𝗰𝗮𝗻 𝘀𝗮𝗳𝗲 𝗹𝗶𝘃𝗲𝘀
I have been meaning to do this for a long time. Finally I did and I'm n…https://t.co/ss0ysOGl6v https://t.co/WPvqmmBFa5

[Stefan Ledinger @SLedinger]

𝗧𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁𝘀 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-𝟮 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻
The Covid-19 pandemic has led to a major push to develop and repurpose drugs, which remains relevant as we're entering the endemic phase of…https://t.co/MzeCg8hvLI https://t.co/ot9hnmokrz

[Stefan Ledinger @SLedinger]

𝗔 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗮𝗻𝗱 𝗶𝗺𝗺𝘂𝗻𝗲 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝘀 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝗮𝗻𝘁𝗶-𝗣𝗗𝟭 𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝗶𝗻 𝗽𝗮𝗻𝗰𝗿𝗲𝗮𝘁𝗶𝗰 𝗰𝗮𝗻𝗰𝗲𝗿
Evidence is mounting that metabolism plays a m…https://t.co/QkX9KTVnd8

[Stefan Ledinger @SLedinger]

𝗦𝗶𝗴𝗻𝗮𝗹𝗶𝗻𝗴 𝗽𝗮𝘁𝗵𝘄𝗮𝘆𝘀 𝗶𝗻 𝗧𝟮𝗗: 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝘁𝗼 𝗱𝗲𝘃𝗲𝗹𝗼𝗽 𝗮𝗻𝗱 𝗿𝗲𝗽𝘂𝗿𝗽𝗼𝘀𝗲 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁𝘀
Although so common, a sizable proportion of patients with Type 2 Diabetes (T2D)…https://t.co/WObcOzTKw2 https://t.co/d8EL1Z96Kb