Small Molecule Therapeutics Lab - IISER Kolkata

Inorganic Medicinal Chemistry Lab, IISER Kolkata | PI: Prof. Arindam Mukherjee |Metal-based systems for biological & medicinal studies. Managed by students.

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

Happy to share our paper published in @angew_chem!

Our work introduces a Ru(II)-sunitinib hydrazide complex that drives ROS-independent ICD via multipronged inhibition of VEGFR2, NF-κB, and telomerase.
🔗 https://t.co/Du7huGTr2S
@SMTL_IISERK @iiserkol @dcsiiserkol

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

My first corresponding-author publication! 🎉

Our Perspective on cGAS–STING pathway modulation by metal complexes has now been published in the Journal of Medicinal Chemistry @ACSBioMed. 🧬

🔗 https://t.co/944bsFW3Z9

@iiserkol @dcsiiserkol @SMTL_IISERK @MukherjeeSujato

[Small Molecule Therapeutics Lab - IISER Kolkata @SMTL_IISERK]

Congratulations to Dr. Shilpendu Ghosh @shilpendu_1 on the successful defense of your Ph.D. thesis! 🎓👏
Wishing you every success in your future endeavors. Here's to many more achievements ahead!
#PhDDefense #Research

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

Honoured to be invited by BRIC-NIBMG @FollowDbtNibmg to deliver a talk on zebrafish as a model for anticancer research. Thank you for the invitation and for the thoughtful discussions.

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

✨Thrilled to share that my design has been selected for a Journal front cover in @J_A_C_S 🎉🧪✨, from our recent publication!
Check it out here 🔗 https://t.co/4J7HgYnkmq
@dcsiiserkol @iiserkol @Arindam_IISERK
#JACS #ACS #Chemistry #FrontCover #ScienceArt

[Small Molecule Therapeutics Lab - IISER Kolkata @SMTL_IISERK]

🎉 Thrilled to share that our cover artwork has been selected for a Journal front cover in @J_A_C_S, featured with our recent publication from @iiserkol. Special thanks to @shilpendu_1 for creating this beautiful artwork ✨🧪

View the issue here 🔗 https://t.co/RcpVIDXLFF

[Small Molecule Therapeutics Lab - IISER Kolkata @SMTL_IISERK]

@sayargh_ Congratulations!! Interesting work

[Small Molecule Therapeutics Lab - IISER Kolkata @SMTL_IISERK]

Banshi presented a poster at the SMMA 2025 conference at IISER Kolkata. Congratulations to Banshi for receiving the Best Poster Award from ACS Publications!!

[Sayar Ghosh @sayargh_]

Our latest findings are now available as a preprint! Excited to share our work "A Fluorogenic Probe for Screening and Kinetic Evaluation of Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors" with the community. | ChemRxiv - https://t.co/mkYS1ZGVf1

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

We’re thrilled to share our latest publication in Small!
-Limantrafin–BODIPY conjugates target TNBC by reducing stemness & metastasis via superoxide-driven phototherapy.
🔗https://t.co/HQmE1jhK7K
@iiserkol @dcsiiserkol @MukherjeeSujato @Arindam_IISERK @sayargh_ @Soumya20085

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

Excited to share our work in JMedChem!
Ir(III)-isatin complexes trigger ferroptosis & autophagy in TNBC via peroxiredoxin downregulation—ROS-driven strategy against apoptosis-resistant cancer. @MukherjeeSujato @dcsiiserkol @Arindam_IISERK @SouryaRoy_D
https://t.co/ewrb2B15Ls

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

🚨📢Excited to share our work in @ChemCommun ! A Fluorogenic Probe for Screening Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors.🔗https://t.co/JmasKZ0gSU @iiserkol @dcsiiserkol @sayargh_ @Aniket_Majee_ @MukherjeeSujato
@Arindam_IISERK @BANSHIROY4

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

🤩Excited to share that our work on Peroxiredoxin Depletion and Oxidative Stress by Cyclometalated Ir(III)-Isatin Complexes is featured as the Front Cover in Journal of Medicinal Chemistry!
🔗 https://t.co/9ZfvOfcW9e
🎨@MukherjeeSujato
@ACSPublications @ACSBioMed #MyACSCover

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Check out the latest issue of #JMedChem!

https://t.co/rXOjzxz86s

In the cover story by Mukherjee et al., the authors depict Iridium complexes disrupting redox homeostasis to induce ferroptotic and autophagic cell death in Triple negative breast cancer.

[J. Am. Chem. Soc. @J_A_C_S]

Indispensable Role of Indazole −NH in Cyclometalated Ir(III) Complexes to Drive ES-PCET with High Phototherapeutic Index | Journal of the American Chemical Society https://t.co/yHOsFl3HKs

[Shilpendu Ghosh 🇮🇳 @shilpendu_1]

Our @J_A_C_S paper is out! ✨
“Indispensable Role of Indazole −NH in Cyclometalated Ir(III) Complexes to Drive ES-PCET with High Phototherapeutic Index.”
🔗https://t.co/oQD9U4bZn8

@dcsiiserkol @iiserkol @ANRFIndia @Arindam_IISERK