S. Shadab

Nephrologist

[CKJ @CKJsocial]

Ten tips to preserve and reuse water in nephrology

https://t.co/FyIl7yKlgc

[CKJ @CKJsocial]

Association of tryptophan metabolites with cognitive impairment in chronic kidney disease

https://t.co/sqwYwS6jyD

[Dr Priti MD,FASN🇮🇳 (प्रिति) @priti899]

Thanks @drsakshinephro For putting out the thread. It was lovely catching up😊

[CKJ @CKJsocial]

Choosing the right antihypertensive drug to avoid intradialytic hypotension

https://t.co/vYDFAjO4VQ

[Dr.Mukesh , MD , DM @dr_immuno29]

🧬 New Antibody Landscape in Lupus (Ann Rheum Dis, 2025)

🔹 Title: Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in SLE

🔹 Authors: Lindblom J. et al., Karolinska Institute
🔹 DOI: 10.1016/j.ard.2025.04.008

1️⃣ Large multicentre proteomic screening (PRECISESADS project) identified new lupus autoantibodies:
 - IgG anti-LIN28A
 - IgG anti-HMGN5
 - IgG/IgA anti-IRF5
 - IgG/IgA anti-TGIF1

2️⃣ These antibodies strongly correlated with high disease activity (SLEDAI ≥10) and were absent in remission/LLDAS states.

3️⃣ IgG anti-LIN28A positive in 🔹53% with CNS lupus and 🔹47% with renal lupus — outperforming anti-dsDNA (20%).

4️⃣ IgA profiling—a new frontier! Suggests mucosal immunity’s role in lupus pathogenesis.

5️⃣ IgA anti-FOSL2 linked uniquely to musculoskeletal disease — potential tissue-specific biomarker.

6️⃣ Autoantibody clusters showed links to DNA repair, RNA regulation, and neuronal pathways — highlighting multi-system mechanisms.

7️⃣ These novel markers may refine lupus stratification, predict flares, and aid in personalised immunotherapy.

📘 Journal: Annals of the Rheumatic Diseases (EULAR, 2025)
🔗 Full Text PDF – Open Access

#SLE #Lupus #Autoantibodies #LIN28A #HMGN5 #IRF5 #TGIF1 #PrecisionMedicine #Rheumatology #EULAR #ARD

[Dr. Hardik Patel 🩺💉 @hardik4u24]

🔥IgA Nephropathy has 2 faces:

🩸Inflammation→ proteinuria, hematuria, crescents, rapid eGFR fall
🧱Fibrosis → slow decline, TIF/TA, minimal hematuria

🎯Tx: steroids, budesonide, iptacopan➝ SGLT2i, RAASi, DEARA

🔗https://t.co/2Qsexmnhtg 🆕@NDTsocial

#IgAN #CKD #Nephrology

[CKJ @CKJsocial]

2025 Update on resistant hypertension in CKD:

where do we stand and where do we go?

🔓https://t.co/d11XPH0nfy

[Int Society of Nephrology @ISNkidneycare]

🫀 Today is #WorldHeartDay
🧩 The ISN presents: CKM Syndrome = Cardio–Kidney–Metabolic Syndrome
🔗 A new paradigm reframing diabetes, CKD & CVD as one interconnected web, not isolated diseases
📜 Here begins a 17-tweet deep dive
🧵Curated by @DrPSVali
#WorldHeartDay2025

[Mythri Shankar 🇮🇳 @nephromythri]

Dr Fernando Fervenza on Management of Monoclonal gammopathy of renal significance

Why is it so hard to detect clone in PGNMID? Does a clone really exist here? Interesting discussion @GlomCon #GlomConHawaii

[Jasmine Sethi @JasmineNephro]

🫘Anti GBM Disease Management

👍When to be conservative

💯 %Crescent

Dialysis > 1 week

Oligoanuria

>50% glomerulosclerosis

https://t.co/8i6fiHYf6v

@NDTsocial @hjanders_hans

[Priya Alexander, MD @MPAlexanderMD]

The kidney bx of a 40yr woman who presented with hypertensive crisis.
There is TMA of arterioles: "Onion-skin" suggests a chronic TMA. Glomeruli: Ischemic
The differential diagnosis is broad. I love this article from #MayoClinicProceedings with a nice algorithm.
@AshimaMakol

[CKJ @CKJsocial]

Asymptomatic hyperuricemia in CKD: mechanisms & clinical implications
🔓https://t.co/J8IP275LqQ
➡️asymptomatic HU is not as bad as previously thought at least in the context of CKD progression & sterile inflammation