Sahil Lall

Interested in the barrier of cellular membranes and proteins therein; ❤️ dynamics and signaling.

[Sahil Lall @Sahil_Lall]

Do kids these days even know how to search for literature?

It is a lot more joyful when it is not just entering a search phrase into your favorite AI or search engine.

[Sahil Lall @Sahil_Lall]

@structure_bio36 That's... sad

[Sahil Lall @Sahil_Lall]

@RolandDunbrack When MBAs take over science, and it is down to marketing, everything is about the narrative. Who's got time to sift through data. LOL.

[Sahil Lall @Sahil_Lall]

I don't see an easy way out

[Ruslan Rust @rust_ruslan]

Can water intake prevent Alzheimer’s disease? No. This is fully AI-generated… but the data below could easily pass as real.

The new ChatGPT image model is truly impressive, but I think it poses a real risk for scientific integrity in future.

For example, I could just generate a dataset with a single prompt that appears to show something like water preventing Alzheimer’s disease. Ironically, we used to laugh at obvious “AI slop” (like those weird generated mice), but that’s changing pretty fast. If I were reviewing this fake figure today, I’m not sure I could reliably tell whether this figure is real or AI-generated?

The bigger issue is that the usual signals we rely on e.g., how realistic or plausible something looks are no longer enough.

I think we really need more comprehensive AI detection and, more importantly, stronger verification standards for scientific submissions going forward. We’ll probably also need better ways to digitize lab notebooks and ensure access to raw data, something closer to how code and version history are tracked...

[Sahil Lall @Sahil_Lall]

A real Moonshot..! Go Humanity..!
Win for science.
#artemis #nasa

[Sahil Lall @Sahil_Lall]

@kzktkhs111 Its the worst if you cannot replicate a pet theory of your supervisor's.. then the blame is on you.

[Sahil Lall @Sahil_Lall]

The reality of capitalism is that everything is a commodity. Science has not escaped this.

Scientific enquiry was about curiosity. Now, too many curious minds require too much resource.

It is a valid competition problem.

Evaluate science in any way, the problem remains.

[Sahil Lall @Sahil_Lall]

@PracheeAC This rings so true.
But is it just the technology that is fuelling it? I feel it is also how we choose hyperspecialized postdocs as the next generation of science-bearers basing the criteria of success on publications. Noise helps when science is done to bring in the next grant.

[Sahil Lall @Sahil_Lall]

It was lovely to contribute the patch clamp electrophysiology to this amazing piece of work. Congratulations to all the authors!

[Dhandapany Perundurai @Dhan_inStem]

Congrats, Prasanth and lab members!
Our recent study in EMBO Molecular Medicine revealed a novel syndrome termed ‘DOSA’ (DCM, Obesity and Sleep Apnea) emanating from a single gene (KCNA2)
https://t.co/HQ8xp2vm6x

[Sahil Lall @Sahil_Lall]

It has been a crazy week with the publication of two (!) de novo designed ion channels.

What a diwali 😀

[Sahil Lall @Sahil_Lall]

Despite chasing single pass transmembrane helices (spTMHs) for a bit, it was a very strange observation 👇

The spTMHs of class I viral fusion proteins are longer than those of other proteins.

Preprint below
https://t.co/6G1dDlKBkM

[Sahil Lall @Sahil_Lall]

"Science becomes a lottery where tenure is the prize, truth an afterthought."

[Prachee Avasthi @PracheeAC]

Right now is the best chance the scientific community has ever had to end the artificial scarcity of academic journals.

Check out my new op-ed urging @NIH @NIHDirector_Jay to disallow taxpayer dollars towards journal publication fees — something both publishers and scientists have played a role in perpetuating.

The last day for public comment on this topic is Monday, Sept 15. It’s time to unleash science.

Links in 🧵

[Sahil Lall @Sahil_Lall]

Is #scitwitter back!? Perhaps in the form of #SciX, #SciEx, #6?

My feed on X has improved a lot over the past few days. I welcome this change wholeheartedly.. thanks to @X for this positive change!

[nature @Nature]

Many Chinese researchers have received enviable benefits and positions after returning from training abroad

https://t.co/6U549vzQDn

[Sahil Lall @Sahil_Lall]

Source of data: Government of India, as reported by the @thewire_in in the article below. (7/7)

https://t.co/YseW51L75l

[Sahil Lall @Sahil_Lall]

By leaving out the word "Unfilled", one could create a serious misinterpretation of the data below. A sensational headline such as "No vacancy for general candidates" and its sure to get people's attention, right? #Reservation (1/7)

[Sahil Lall @Sahil_Lall]

The beauty of data lies in its ability to facilitate the formulation and testing of hypotheses. Consequently, it serves as the foundation for scientific inquiry and inquisitive temperament. (6/7)