Pabi Sahoo (ପବିତ୍ର ସାହୁ)

Assistant Professor at Rutgers University | Molecular Neurobiologist | Neural repair | Neurodevelopment

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

New preprint from our lab: OCNDS (Okur-Chung Neurodevelopmental Syndrome) mutations in CK2α converge on one downstream culprit, dysregulated G3BP1 granules. https://t.co/FaAO6SryBT

[Manasi Agrawal, Ph.D. @manasiagrawal1]

It’s always nice when all the pieces of a story finally start coming together!

There were quite a few surprises along the way, but the coolest part was seeing different members of the team work independently, yet arrive at similar conclusions!

Here’s the preprint!

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Check out this excellent piece of work from the Twiss lab! Source: Science Advances https://t.co/LtPwH2jlqH

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

A huge thanks to our funding agencies (@MerkinPnnrCtr, @NJDeptofHealth, @NIH), and collaborators (@BonnieFirestein, others not on this platform).

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

New preprint from our lab: OCNDS (Okur-Chung Neurodevelopmental Syndrome) mutations in CK2α converge on one downstream culprit, dysregulated G3BP1 granules. https://t.co/FaAO6SryBT

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Huge effort from an incredible team, @manasiagrawal1, @meghal_desai, @GhumraShru98494 (co-first authors), and collaborators across Rutgers, Michigan, UCLA, and Paris.

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Now our lab is NIH funded. This funding gives us real stability and room to keep building on the questions we care about. I am proud of what my team has accomplished and look forward to what lies ahead. Huge thanks to my mentors and #NIGMS.

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Read this exciting work from the @KristyWelshhans lab led by @manasiagrawal1. Very happy to have contributed to this story.

[Brain @Brain1878]

Using human and mouse models of Down syndrome, Agrawal et al. show that overexpression of the chromosome 21 gene DSCAM disrupts neuronal development and axon guidance, leading to altered neural connectivity and contributing to learning impairments. https://t.co/tOIemCtzrV

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Stress granules restrain ferroptosis by sequestering ferritin | Nature Cell Biology https://t.co/vLHXR8aYQG

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

First major grant for the lab. Thank you, #NJCBIR, for believing in us. Now let's get back to the bench to get that work done :)

[Manasi Agrawal, Ph.D. @manasiagrawal1]

This review was a great opportunity to take a step back and appreciate the progress in iPSC-based models for neural repair.

But can we truly model human neural repair?

Excited to share our review that discusses how far we’ve come in the field while highlighting what’s missing!

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link https://t.co/bSpwMQzZvn

[Rutgers University @RutgersU]

Congratulations to 8 Rutgers researchers named fellows of the prestigious American Association for the Advancement of Science.

https://t.co/ldhZUnYmjq

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

How many axon localization elements are in one mRNA? mTor mRNA seems to have at least 3. Read this interesting preprint from the Fainzilber lab.
Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth https://t.co/lM0uNqI2A0

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

There is a current push towards doing biological research using only hiPSC models, but are we there yet? @manasiagrawal1 nicely discusses it in this review using neural repair as a model system.
https://t.co/H6EdAXZdxf

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science https://t.co/ecC0oGNE2r