This review was a great opportunity to take a step back and appreciate the progress in iPSC-based models for neural repair.
But can we truly model human neural repair?
Excited to share our review that discusses how far we’ve come in the field while highlighting what’s missing!
Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link https://t.co/bSpwMQzZvn
How many axon localization elements are in one mRNA? mTor mRNA seems to have at least 3. Read this interesting preprint from the Fainzilber lab.
Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth https://t.co/lM0uNqI2A0
There is a current push towards doing biological research using only hiPSC models, but are we there yet? @manasiagrawal1 nicely discusses it in this review using neural repair as a model system.
https://t.co/H6EdAXZdxf
Our methods paper is now online. It was co-led by Shruti Ghumra and @manasiagrawal1. If you are struggling with enriched axonal preparations, you may find this paper useful! JoVE https://t.co/EkNIHacd03
@meghal_desai received a one-year Postdoctoral Fellowship from the
New Jersey Autism Center of Excellence (NJACE). Congratulations, Meghal, and thank you, NJACE, for supporting our research!
Thrilled to share our new work in Nature Neuroscience!
Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS.
https://t.co/FMksQim7eF