‼️ New preprint from the Morris Lab at the @DonnellyCentre! This is our latest work in GWAS‑to‑function to study the genetic determinants of human bone formation and osteoporosis!
🧬 ➡️ 🦴
https://t.co/8U1FeyfdVR
We're looking for a postdoc! Cool ERC-funded project digging into gene dosage variation with CRISPR+sc+computational methods. Dynamic environment at KTH / SciLifeLab Stockholm campus, plus interactions with our New York team. Apply or email for more info:
https://t.co/TBuH37dmUq
Want an introduction to Genome wide association studies? See my video for @FIDELIO_ITN | @EU_H2020 on genetic variation in type II diabetes.#diabetes
https://t.co/htcmDUzAjZ via @YouTube
Are you a bachelor or masters student within Erasmus MC?
We are looking for students to help with research within the lab of Translational Skeletal Genomics. Our lab investigates a broad range of research topics and comprises of a mixture of clinicians and full time researchers
Thanks Ling. Many thanks also to all of the co-authors.
Here we discuss both the Polygenic and Monogenic contributions to paediatric fractures and the interplay between the two.
Please see our latest open access review lead by Fjorda Koromani:
"Type 2 Diabetes Mellitus and Vertebral Fracture Risk"
"There are currently no guidelines on how to manage patients with T2DM who might be at risk for osteoporotic fractures."
https://t.co/qD5T4YoMdB
FIDELIO online training course #CriticalAppraisal of #RealWorldEvidence December 2-4 has 6 places available for external participants. See more info here and apply using our website contact form. Please RT. @MSCActions
“The AMPLITUDE O trial's results will inform the use of exendin‐based GLP‐1 RA to people with #T2D and high #CVD risk, with and without #CKD, in the presence and absence of an SGLT2 inhibitor” https://t.co/pcHzaPreTv
I count 259 lead SNPs in this Manhattan plot of bone mineral density. The strongest is at rs7801915 probably tagging the WNT16 gene, with a p-value of 1e-306
Here's a diagram of WNT16 at work, regulating bone growth:
https://t.co/Cd5pnya6u9
Last day of the @ASBMR there have been so many great talks on such a diverse array of topics. Really excited to be presenting my work assessing the association between BMD and Alzheimer's Disease #bone#brain in the 'Skeletal Consequences of Diverse Morbidities' session. 🦴🧠