Sam Stampfer

ID Doc, structural virologist, and board game enthusiast working on vaccine development. Views are my own.

[Sam Stampfer @SamInSilico]

@ItsInDeKalb Hey DeKalb road repair, please just fix the bridge/road behind sage hill plaza (broken since 8/2023) or at least open it to pedestrians and bikers. I watched your team drive down it so I know it can handle our weight. This is way safer than biking down Clifton.

[Sam Stampfer @SamInSilico]

Feeling very ID-Doctorly right now strolling the hospital with a CAPR in my hand and Cary Blair stool media in my pocket. Ready for anything!

[Sam Stampfer @SamInSilico]

Thought: when states criminalize transition care for minors (for theoretical harm), they should logically also outlaw anything that causes KNOWN harm to kids- like vaccine refusal, or smoking around kids, or storing a gun in the home. Can't imagine any of that happening . . .

[Sam Stampfer @SamInSilico]

@aoglasser No more non-omcricron shots! Thrilled that they made this change 🙂 Makes way more sense for initial vaccination. https://t.co/u5vtdgoFLb

[Sam Stampfer @SamInSilico]

@limbsandlungs @Emory_TB_Center @CITC_TB @tbcontrollers @ABsteward @CarlosdelRio7 @IDSAInfo @EmoryInfectDis @PaulSaxMD @SNTC_TB @DavidHollandMD @saritashahATL Great work and I like the charts!

[Sam Stampfer @SamInSilico]

Wordle 643 2/6

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Talk about luck....

[Sam Stampfer @SamInSilico]

@zev_stampfer You don't need that. Just go with Destihl Dill Pickle sour beer. 6 ounces of delicious drink, plus 6 more ounces that don't need to be there.

[Sam Stampfer @SamInSilico]

@jeffm1981 Those spike evolutions are to escape pre-existing immunity from OAS. And shorter incubation doesn't matter if you have good mucosal immunity prior to virus exposure- that's part of the mechanism preventing infection in people who were very recently infected or vaccinated.

[Sam Stampfer @SamInSilico]

Why are we still using a wild-type primary series COVID-19 vaccine that has essentially no neutralization against XBB.1.5 in an all omicron world?! It ought to be a bivalent or BA.5 primary series. Hopefully they update this before I have another kid. Ugh.

[Sam Stampfer @SamInSilico]

@jeffm1981 See my response to the other comment. It's original antigenic sin. Somewhat like the issues with flu vaccine at this point.

[Sam Stampfer @SamInSilico]

@jeffm1981 The original matched vaccines had fantastic protection against mild disease. We don't have that anymore due to our immune systems being biased towards that original strain. For a new child, better to bias their immune system towards the omicron variants for optimal protection.

[Sam Stampfer @SamInSilico]

@jeffm1981 Well right that's why you still vaccinate! But much better to have a well-matched durable antibody response. For example, so that your two year old has sterilizing immunity and doesn't transmit virus to your unvaccinated three month old.

[Sam Stampfer @SamInSilico]

@drwittID @jestjac @JessH_A @EmoryInfectDis @davidvanduin Congrats!

[Sam Stampfer @SamInSilico]

Maybe McCarthy should make concessions to centrist democrats in exchange for their votes, instead of trying to capitulate to the crazy ultra-right congresspeople whose election platforms were based heavily on wanting to undermine our democracy. Or is cooperation that dead?

[Sam Stampfer @SamInSilico]

Just published our analysis of binding antibodies from a third dose of mRNA vaccine for COVID-19 in immunocompromised patients- Moderna as a 100 microgram booster keeps outperforming Pfizer in this group. More details: https://t.co/Wmfx4VqwnS

[Sam Stampfer @SamInSilico]

Either I miss the northeast or I really love my job. All I know is that I felt true happiness while biking into work on a sunny 15 degree day with little patches of black ice scattered about. Also I think the cold made my hydraulic brakes work better. 😃

[Sam Stampfer @SamInSilico]

@JillHolds @SundermannAJ Horrifying

[Sam Stampfer @SamInSilico]

@jessecouk @bluestein @eric_sapphire Took me 60 seconds to vote in DeKalb today.

[Sam Stampfer @SamInSilico]

@eeeejjjaaaa Anna's Taqueria and get a quesadilla stuffed full of extras. Your life will never be the same.

[Sam Stampfer @SamInSilico]

@MarieFollayttar @pfizer I was able to get an emergency IND. It took a lot of people and at least 6 hours of work on my part. This needs to be easier.

[Sam Stampfer @SamInSilico]

#IDTwitter anyone know how to get an extended 20 day Paxlovid supply for a patient on rituximab with multiple COVID rebounds post hospitalizations? Not having a ton of luck through @pfizer Attempting to treat similarly to this: https://t.co/myTcMtEpOk