Sam

[Afshine Emrani MD FACC @afshineemrani]

An 80-year-old Japanese-American woman with advanced Alzheimer’s—bedbound, incontinent, and speaking only in single syllables for years—just shattered our understanding of neurodegeneration.

After a single supervised 5-gram dose of psilocybin mushrooms (Enigma strain), she woke up after 19 hours and did the impossible:
+ Regained full speech (forming complete, coherent sentences)
+ Recovered lost memories (recalling long-forgotten life events)
+ Regained mobility & continence (dressing herself and staying dry)
+ Restored eye contact and humor
A follow-up 3-gram dose one month later boosted her verbal fluency and agility even further. These gains lasted for weeks.

🧠 This Is Not A Cure. It’s Something More Profound.
The case report, published in Frontiers in Neuroscience (May 27, 2026), proves that functions we assumed were irreversibly destroyed by dementia are actually still there—they are simply trapped behind broken neural gates. Psilocybin bypassed the damage. How? Through explosive, rapid neuroplasticity:
+ The 5-HT2A Switch: Psilocybin floods 5-HT2A serotonin receptors, triggering a massive spike in BDNF (Brain-Derived Neurotrophic Factor).
+ Neural Rewiring: BDNF acts like fertilizer for the brain, driving dendritic spine growth, synaptogenesis, and the repair of broken networks.
+ Circuit Restoration: It downregulates chronic neuroinflammation and re-establishes critical communication between the hippocampus and prefrontal cortex.

🛑 The Tragedy of Our Delay: Johns Hopkins is already studying psilocybin for depression in early-stage cognitive decline. But for late-stage, severe patients? It is an absolute shame that we aren't taking these trials more seriously. Modern medicine has exactly zero treatments that restore lost function in advanced dementia. This single case demands immediate action.
We don't have time to wait for a 10-year bureaucratic pipeline while millions of minds fade into the fog.

⚡ The Directive for Compassionate Use: President Trump’s executive order accelerating psychedelic research gives us the exact legal framework we need. We must bypass the standard red tape and establish compassionate use protocols immediately for advanced patients. For millions of families watching their loved ones slip away, this case report is a thunderbolt of hope. The brain still holds secrets, and science moves fast when we get out of its way.

What if a single guided experience could give you back one last conversation with the person you love?

🔄 Share this if you want real hope for dementia. Access and research must accelerate NOW.

#Psilocybin #Alzheimers #Neuroplasticity #BDNF #MedicalBreakthrough #CompassionateUse #Dementia

[unusual_whales @unusual_whales]

BREAKING: More than half of the publicly identified donors to President Trump’s White House ballroom project have won new or expanded federal contracts worth more than $50 billion, per WaPo

[Ken from KY-04 @MassieNation19]

This should make you sick as an American .

[Polymarket @Polymarket]

JUST IN: Thomas Massie has officially filed a statement of candidacy, allowing him to raise money for a potential 2028 run.

[RodeoProfessor @RodeoProfessor]

The Idaho constitution requires the state to mange state public land for “long term financial return.” What that means is a 5th generation Teton ranching family will get the boot from their lease when well connected billionaires ask the Idaho Land Board to sell, like what happened with this Tetons Driggs 160 case.

The Mike Lee thing failed, so the next move in the playbook is transferring public land to the states who will then say “we can make more money off this land so we are selling it off.” They’re saying he won’t build a subdivision here, but there’s nothing stopping him as it’s private land now.

The billionaire who bought the parcel is a New York movie producer and tech investor with a lot of financial interests in AI and data centers. He lives full time in Pittsburgh. When we carve up the American West like this, and make something that once was public private, the possibility for development of open land increases.

What made conservation of the Greater Yellowstone Ecosystem possible as one of the only fully intact ecosystems left in America was the scale and connectivity of public land for seasonal migrations of elk, mule deer, pronghorn, and bison. Herds follow green waves of grass with the season. Suburban development has stopped these migrations almost everywhere else.

Public land prevents fragmentation into housing developments that would end these migrations too. Ranchers are a big part of this as ranch lands are often some of the most productive low elevation habitat for herds or they fall along migration corridors. Ranches maintain these large open spaces that allow migration to continue. If the buyer keeps the land undeveloped, that would be great, but now that it’s private and the 5th gen family who had a grazing lease there into the 2030s is gone, there’s no guarantee.

Another part of America sold off to the highest bidder because the line must go up.

[Max Marchione @maxmarchione]

Retatrutide phase 3 obesity trial just came out and the results are genuinely insane:

- 28.3% bodyweight lost on 12mg over 80 weeks
- 70.3 pounds on avg. or 31.9 kg
- 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory)
- 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients
- 65.3% of 12mg patients dropped below the obesity BMI threshold
- 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%)
- significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP
- no cardiac or liver signals

Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.

[Dave Smith @ComicDaveSmith]

If Massie loses tonight, he should run for President.

If Massie wins tonight, he should run for President.

[Tuki @TukiFromKL]

🚨do you understand what just happened..

Trump sued his own IRS for $10 billion over leaked tax returns.. then settled with his own DOJ.. and the settlement created a $1.776 billion taxpayer-funded fund to compensate his political allies

the president filed the lawsuit.. the president's DOJ settled it.. the president's allies collect the money.. and you're paying for it

the fund covers Jan 6th defendants.. Mar-a-Lago raid claims.. the Russia investigation.. anyone who says they were a victim of "lawfare" can file a claim and get a check

they named it the "Anti-Weaponization Fund".. and made the number $1.776 billion.. they even made the corruption patriotic

in 1974 Nixon resigned for using government agencies against political enemies.. in 2026 the government is cutting checks to political allies and calling it justice

[Thomas Massie for Congress @MassieforKY]

@realDonaldTrump Is this the one?

[GBX @GBX_Press]

🇺🇸 REP. MASSIE:
"Anyone who went to rape Island needs to be behind bars, even the billionaires."

"Do NOT f*ck this bill up."

[Blake ™ @NeilNevins]

i know we're already way beyond the pale, but in any normal society, this should be pitchforks and torches type stuff

[James Li @5149jamesli]

Thomas Massie: "I vote with Republicans 91% of the time. And the 9% I don't, they're taking up for pedophiles, starting another war, or bankrupting our country."

An absolute mic drop. 🎤⬇️

[Peter Schiff @PeterSchiff]

The only Republican in the House who actually cares about the Constitution, votes his conscience, wants to end undeclared wars, and stop the runaway deficit spending that is bankrupting our country is the one guy Trump wants to get rid of. What does that tell you about Trump?

[kira 👾 @kirawontmiss]

"You want to really make a pandemic, make hantavirus human transmissible"

> posted in 2012

[jake @wormpuller]

Larry did not have ties to Moe, per Curly

[Thomas Massie @RepThomasMassie]

1913 “trust us” they said. “The federal income tax will only apply to a few people and it won’t be much.” Repeal the 16th amendment.

[Jason Bassler @JasonBassler1]

A company funded by the CIA, used for predictive policing, mass data fusion, overseas targeting ops, and founded by Jeffrey Epstein's "great friend," is now responsible for keeping America’s food “safe.”

Totally normal. Nothing to see here.

[Declaration of Memes @LibertyCappy]

Thomas Massie gets it

[Jamie Bonkiewicz @JamieBonkiewicz]

We’re getting taxed twice by tariffs, first at the register, then again through our tax dollars reimbursing the same corporations we already paid inflated prices to…

We are being fucking looted.

[trash jones @jzux]

jesus fucking CHRRRRRIIIIIIISTTTTTT