Extremely happy to announce the publication of our study on renal acid/base handling and the association between our novel urine acid/base score and progression of chronic kidney disease @JASN_News@ASNKidney https://t.co/IMXEMbMboe. A short 🧵 on what we found. Happy to discuss!
The secretin receptor (SCTR) stimulates urine alkalization by activating β-ICs. This study suggests loss of SCTR impairs the increase of renal base excretion during acute base loading & SCTR is necessary for acute correction of metabolic alkalosis https://t.co/e0Adz84cSX
1/ Two years ago, we suggested quantification of urine bicarbonate excretion following oral sodium-bicarbonate loading as a measure of CFTR function in patients with CF. Today, our clinical follow-up study is online: https://t.co/P04YT9dw0Z #cysticfibrosis@Leip1