Jens Leipziger

[Peder Berg @berg_peder]

Extremely happy to announce the publication of our study on renal acid/base handling and the association between our novel urine acid/base score and progression of chronic kidney disease @JASN_News @ASNKidney https://t.co/IMXEMbMboe. A short 🧵 on what we found. Happy to discuss!

[JASN_News @JASN_News]

A study describes a novel urine acid/base score to assess tubular acid excretion capacity & identify the state of early acid retention in CKD. Early signs of acid retention (low acid/base-score) are associated with markedly higher risk for CKD progression https://t.co/gLf7bbXFIP

[Jens Leipziger @LEIP1]

Wonderful and lively presenters and audience at our Physiology in Focus 2024 meeting where the gut met the kidney

[JASN_News @JASN_News]

ADPKD is characterized by multiple bilateral kidney cysts which gradually enlarge, resulting in a decline in kidney function. This study found P2Y2R was significantly expressed in human and mouse polycystic kidneys https://t.co/WP8oV1B9tT

@LEIP1

[Aarhus Universitet @AarhusUni]

Det blev en flot festdag den 29. maj i Aulaen, hvor professor Alexandros Iosifidis modtog Victor Albeck-prisen 2024. På samme tid modtog 5 talentfulde ph.d.’er Aarhus Universitets Forskningsfonds ph.d.-priser. 👏
@AUFF2017

[Peder Berg @berg_peder]

This was a great collaboration with the Department of Gastroenterology at Rostock. @LEIP1
Also, proud to note that this is my first senior authorship!

[Peder Berg @berg_peder]

Have a look at our just published review on the gastrointestinal hormone secretin where we outline its role in acid-base balance @PflugersArchiv. Find the full text here: https://t.co/EYwjnhrigh
@LEIP1 @Samuel_Svendsen

[Peder Berg @berg_peder]

Trimethoprim, a widely used antibiotic, is known to cause hyperkalemia and metabolic acidosis, especially when used in high doses. In a just published paper @AJPRenal we investigate the effect of trimethoprim on sodium, potassium, and acid excretion. https://t.co/71u62IZWCx

[Jens Leipziger @LEIP1]

@MLGumz @PAWellingMD I am very sad to hear this. It feels only yesterday that Charles helped us work up the question how benzamil causes acute urine alkalisation. (AJP Renal 2021).

[JASN_News @JASN_News]

This study suggests that loss of secretin receptor (SCTR) impairs the appropriate increase of renal base excretion during acute base loading and that SCTR is necessary for acute correction of metabolic alkalosis https://t.co/e0Adz84cSX

@LEIP1 @berg_peder @Samuel_Svendsen

[JASN_News @JASN_News]

The secretin receptor (SCTR) stimulates urine alkalization by activating β-ICs. This study suggests loss of SCTR impairs the increase of renal base excretion during acute base loading & SCTR is necessary for acute correction of metabolic alkalosis https://t.co/e0Adz84cSX

[Peder Berg @berg_peder]

AE4 has been implicated in renal NaCl handling. Here, we show that loss of AE4 impedes pendrin regulation and causes severe alkalosis during base loading and acidosis during acid loading. A renal acid-base sensor, or? Read the paper @NatureComms https://t.co/FPMb1GOaCn

[Henrik Dimke @h_dimke]

Next week at the Sandbjerg Estate in Denmark, the 52nd meeting on Membrane Transport will take place. Please follow @SandbjergM11140 for updates from the meeting and for more information on future meetings.

[Peder Berg @berg_peder]

1/ Two years ago, we suggested quantification of urine bicarbonate excretion following oral sodium-bicarbonate loading as a measure of CFTR function in patients with CF. Today, our clinical follow-up study is online: https://t.co/P04YT9dw0Z #cysticfibrosis @Leip1

[Annals of Int Med @AnnalsofIM]

A study of patients with #CysticFibrosis has found that challenged urine bicarbonate excretion may offer a new, simple, and safe quantification of CFTR function and the extent of its pharmacologic improvement: https://t.co/uApt9bZfK8

[Jens Leipziger @LEIP1]

Alkalosis-induced hypoventilation in cystic fibrosis: The importance of efficient renal adaptation https://t.co/sIWNJYYkND

[Jens Leipziger @LEIP1]

Samuel Levi Svendsen is leaving our lab today. The greatest tubule perfusionist of Denmark will start his Clinical Training on monday

[Jens Leipziger @LEIP1]

@klaus_koren @DFF_raad @PDJF_dk In the way to our UABA

[Jens Leipziger @LEIP1]

Impaired Renal HCO3- Excretion in Cystic Fibrosis https://t.co/jZ5P9ybnlU
5 years of work from mouse to man. Hope you like it.

[Jens Leipziger @LEIP1]

Hej @LSatlin.