Santiago Clocchiatti-Tuozzo, MD, MHS

MD, MHS. Neurology Resident at Yale New Haven Hospital, Yale University. Focused on personalized medicine of brain health and neurology using genetics.

[Santiago Clocchiatti-Tuozzo, MD, MHS @SanticlocMD]

Excited to share our new work in Neurology: Does intensive BP lowering differ in deep vs lobar ICH? https://t.co/IFeVQKqFSF
Signals of heterogeneity across 3 ICH trials suggest location-specific effects.
IPD meta-analyses and targeted trials are needed.
@mxhawkes @GuidoFalconeMD

[Umberto Pensato @UPensato]

A Standardized Anatomical Classification of Intracranial Hemorrhage. Hope is gonna simplify communication. @Ash_Shoamanesh @PrCCordonnier @sheth_kevin @JoshGoldsteinMD @vagal01 @SalmanRust94258 @DavidSeiffge @demchuk_andrew @HUNIMED @DCNSNeuro #stroke
https://t.co/ktql08XYhH

[Santiago Clocchiatti-Tuozzo, MD, MHS @SanticlocMD]

@ScholarshipfPhd English

[JAHA @JAHA_AHA]

Single-cell RNA-seq of #stroke clots reveals cause-specific signatures, suggesting new biomarkers. #AHAJournals @DadaRenedo @jn_acosta @sujijantaratMD @AndrewBKoo @CyprienRivier @SanticlocMD @jpantonios @GuidoFalconeMD @LaurenHSansing @MatoukCharles https://t.co/bxQXfmfIdt

[Richa Sharma, MD, MPH @RichaSharmaMD]

Lower risk of recurrent stroke among patients with ESUS and left ventricular dysfunction randomized to apixaban in the ARCADIA trial in our post-hoc analysis.

https://t.co/4tHlt8PF0Z

@hoomankamel @MitchElkind @DineshJillella @StrokeAHA_ASA @ShadiYaghi2

[Yale Neurology @NeurologyYale]

A new study led by @SanticlocMD, a resident in the Department of Neurology, demonstrates how a genotype linked to Alzheimer's disease can also increase an individual's risk of intracranial hemorrhage, when prescribed a common anticoagulant.

https://t.co/s8S50S2uQw

[Guido J. Falcone MD, ScD, MPH @GuidoFalconeMD]

Very happy to share our new paper looking at polygenic resistance to blood pressure treatment and risk of stroke. Clinically meaningful … and ACTIONABLE!

Thank you @shufanhuo for leading the charge!

Paper
https://t.co/q2dJu7aSmi

@NeurologyYale @YaleNeuroICU

[Daniela Renedo @DadaRenedo]

New study out: 📊

In neurointerventional surgery, women remain only 1 in 10 authors.
First authorship ↑ (10%→17%), but senior/last authorship barely moved (6%→9%).
Progress is happening, but equity in leadership is still far away.

[Maximiliano Hawkes, MD @mxhawkes]

Check out our latest article exploring the advances in posterior reversible encephalopathy syndrome: pathophysiology, diagnosis, and treatment.

https://t.co/ljp992u2Bn

[Guido J. Falcone MD, ScD, MPH @GuidoFalconeMD]

Genetic information can both inform pathophysiology and guide patient selection.

Happy to share our new study on APOE e4 and risk of intracranial hemorrhage in AF patients anticoagulated with apixaban.

Take a look!
https://t.co/PkTnsRXOcT

@NeurologyYale @YaleNeuroICU

[Thomas Gill @MrDisability]

APOE and Intracranial Hemorrhage in Atrial Fibrillation https://t.co/B6ectJJ4B1

[Eric Topol @EricTopol]

Having an APOε4 allele may be risk factor for brain hemorrhage with apixiban, a commonly used blood thinner for atrial fibrillation
https://t.co/SmIqMiSdDt

[Santiago Clocchiatti-Tuozzo, MD, MHS @SanticlocMD]

Beyond excited to see our paper online! @JAMANeuro

We show how genetics (APOE ε4) may help us manage the complex balance of bleeding and thrombotic risk in atrial fibrillation patients on apixaban.

Huge thanks to @GuidoFalconeMD and @MrDisability for their mentorship.

[JAMA Neurology @JAMANeuro]

APOE epsilon ε4 is a significant risk factor for intracranial hemorrhage in patients with atrial fibrillation on apixaban. https://t.co/WdEGPe62BN @sheth_kevin @MrDisability

[Guido J. Falcone MD, ScD, MPH @GuidoFalconeMD]

Thank you @JGrutzendler, #YaleADRC and @Yale_OAIC for the opportunity to present our work on genomic emulation of clinical trials and multiomic analyses focused on #WMH.

Always great to showcase the ongoing work of @CyprienRivier and @SanticlocMD

@NeurologyYale @YaleNeuroICU

[Guido J. Falcone MD, ScD, MPH @GuidoFalconeMD]

Great job @SanticlocMD! Presenting at #ESOC2025 our work on clinical trial emulation and MR of Factor XI pathways.

Go Santi!

@NeurologyYale @YaleNeuroICU @Yale_OAIC

[Santiago Clocchiatti-Tuozzo, MD, MHS @SanticlocMD]

@ssanchezneuro @esamaniego @YaleNeurons Congratulations Sebas!

[Santiago Clocchiatti-Tuozzo, MD, MHS @SanticlocMD]

Thrilled to see our new paper in print! 🧠📄

While intensive BP lowering helps in ICH, it’s unclear if both deep and lobar bleeds benefit equally. Take a look:

https://t.co/4f0v26tPEo

Immensely thankful to my mentors @GuidoFalconeMD and @mxhawkes

[Guido J. Falcone MD, ScD, MPH @GuidoFalconeMD]

Very rewarding to work with @DadaRenedo, @sheth_kevin and many others in this study using @AHAScience #GWTG data to evaluate whether SDOH influence outcomes in pts w subarachnoid hemorrhage.

#YaleCBMH @YaleNeuroICU

Paper
https://t.co/zHtYqQR695

[Santiago Clocchiatti-Tuozzo, MD, MHS @SanticlocMD]

@AANmember @GuidoFalconeMD @YaleNeurons @NeurologyYale @YaleMed @MrDisability @Yale_OAIC Thank you!

[Guido J. Falcone MD, ScD, MPH @GuidoFalconeMD]

Very proud of @SanticlocMD who matched at @YaleNeurons today!

Super congrats, Santi!

@NeurologyYale @YaleMed @MrDisability @Yale_OAIC