Very proud to share our latest publication on the discovery of #KCTD7 function and #calpain regulation by atypical ubiquitination.
Massive kudos to superb lead author @JaiSharma__ whose visionary ideas and tireless efforts were crucial to make it happen!
https://t.co/mwxQqtdDUA
Amazing work from the @ZhandongLiu lab!
Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders
https://t.co/wHV7VjCVy9
The Sardiello lab has just moved to Washington University in St. Louis. Contact us if interested to join as a post-doc, computer scientist, or lab manager/technician.
Super stoked to finally see my graduate school paper out today in @jclinicalinvest. We show that a CLN6-CLN8 complex (that we refer to as EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal system), recruits lysosomal enzymes at the ER to promote their Golgi transfer.
Our new article showing that CLN6 and CLN8 are obligate partners in the recruitment of lysosomal enzymes in the endoplasmic reticulum for Golgi transfer https://t.co/OSselaV6GN
Check out our new PNAS paper showing mTORC1-independent lysosomal depletion and abnormal glycogen storage in tuberous sclerosis
https://t.co/36ywAamlOA
Dr. Paul Luzio's commentary on our article "CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis"
https://t.co/iE2f3aG2I2
Our new article showing that ER-to-Golgi transport of lysosomal enzymes requires CLN8, a Batten disease protein. #lysosome#NatureCellBio
https://t.co/ceQWFoI1sb