Sardiello Lab

Washington University in St. Louis. Main topics: lysosomal and mitochondrial biogenesis, neurodegenerative diseases, TFEB.

[Sardiello Lab @SardielloLab]

Very proud to share our latest publication on the discovery of #KCTD7 function and #calpain regulation by atypical ubiquitination.

Massive kudos to superb lead author @JaiSharma__ whose visionary ideas and tireless efforts were crucial to make it happen!

https://t.co/mwxQqtdDUA

[Sardiello Lab @SardielloLab]

Great work from the @HastingsLab!

[Michelle Hastings @HastingsLab]

Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease | Nature Medicine https://t.co/0UpFUxoY7l

[Sardiello Lab @SardielloLab]

Amazing work from the @ZhandongLiu lab!
Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders
https://t.co/wHV7VjCVy9

[Sardiello Lab @SardielloLab]

@LeventalLab Thanks Ilya!

[Sardiello Lab @SardielloLab]

@Stephane_MTL Thank you for helping spread the word!

[Sardiello Lab @SardielloLab]

The Sardiello lab has just moved to Washington University in St. Louis. Contact us if interested to join as a post-doc, computer scientist, or lab manager/technician.

[Sardiello Lab @SardielloLab]

Solving the CNL6 mystery in Batten disease: https://t.co/65J0XTl2tI

[From the Labs at Baylor College of Medicine @BCMFromtheLabs]

Congratulations @lakshyabajaj5 @SardielloLab et al for solving the #CLN6 puzzle in #BattenDisease! @jclinicalinvest @bcmhouston @TCHResearchNews

[Lakshya Bajaj @bajajlab]

Super stoked to finally see my graduate school paper out today in @jclinicalinvest. We show that a CLN6-CLN8 complex (that we refer to as EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal system), recruits lysosomal enzymes at the ER to promote their Golgi transfer.

[Sardiello Lab @SardielloLab]

Our new article showing that CLN6 and CLN8 are obligate partners in the recruitment of lysosomal enzymes in the endoplasmic reticulum for Golgi transfer https://t.co/OSselaV6GN

[Sardiello Lab @SardielloLab]

Amazing work from the @KlischTiemo lab

[Tiemo J. Klisch @KlischTiemo]

https://t.co/loN5YWwlwu

[Sardiello Lab @SardielloLab]

Very proud and grateful for this award. A big thank you to all past and current lab members and our many collaborators!

[From the Labs at Baylor College of Medicine @BCMFromtheLabs]

Five researchers received the 2019 Michael E. #DeBakey M.D. #Award for Excellence in #Research @amilosav @SardielloLab @BrittonTML @BCMCancerCenter @TCHResearchNews https://t.co/lf0ksLUfgJ via @bcmhouston

[Sardiello Lab @SardielloLab]

Check out our new PNAS paper showing mTORC1-independent lysosomal depletion and abnormal glycogen storage in tuberous sclerosis
https://t.co/36ywAamlOA

[From the Labs at Baylor College of Medicine @BCMFromtheLabs]

How can #mutations in a #protein that is not in the #lysosome result in a #lysosomalstoragedisorder? #CLN8 @SardielloLab @NatureCellBio @bcmhouston @TCHResearchNews https://t.co/SMot6kmNL6 #Batten

[Sardiello Lab @SardielloLab]

Dr. Paul Luzio's commentary on our article "CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis"
https://t.co/iE2f3aG2I2

[Sardiello Lab @SardielloLab]

Our new article showing that ER-to-Golgi transport of lysosomal enzymes requires CLN8, a Batten disease protein. #lysosome #NatureCellBio
https://t.co/ceQWFoI1sb

[Sardiello Lab @SardielloLab]

Our new article showing that Src controls mTORC1 activity
https://t.co/g0NCPpfwFn

[Sardiello Lab @SardielloLab]

Our #Autophagy paper is finally out! Congrats Parisa and a big thank you to all our collaborators.
https://t.co/ILd9iHIdVn

[Sardiello Lab @SardielloLab]

Our review on the autophagy-lysosomal pathway in LSDs and late-onset neurodegenerative diseases is out!
https://t.co/kCO3aO9B1F