Sarlah Lab

Complex Molecules. Enabling Synthesis.

[Sarlah Lab @SarlahLab]

Check out our recent approach to sannamycins, featuring dearomative hydroamination of benzene, interesting skeletal reorganization, and novel use of biomass material as a carbohydrate precursor.

[J. Am. Chem. Soc. @J_A_C_S]

Enantioselective Total Syntheses of Sannamycins A and B | Journal of the American Chemical Society @SarlahLab @RiceChemistry @RiceUniversity @ChemistryUIUC https://t.co/ps6QWJCPP7

[Total Synthesis @TotalSynthesis]

Stereodivergent #Synthesis of Perhydrobenz[e]indene Terpenoids by Cheng Yang, Christopher J. Huck, @YaroslavBoyko4, Shang Ning, Uroš Vezonik, Alexander S. Shved, Scott E. Denmark, Binh Khanh Mai, David Sarlah @SarlahLab at @RiceChemistry in @J_A_C_S https://t.co/jWZye2eG41

[Sarlah Lab @SarlahLab]

Check our synthesis of nimbolide! A streamlined approach enabled by a powerful borylative Heck reaction and a stereochemically interesting alkyl ether formation. Fun fact: two identical twins working on the same molecule...I guess they are trying to keep it in the family😅

[J. Am. Chem. Soc. @J_A_C_S]

Stereoselective Total Synthesis of Nimbolide | Journal of the American Chemical Society @TotalSynthesis @TotalSyntheses @SarlahLab @RiceChemistry https://t.co/hZ2xDIIiEE

[Sarlah Lab @SarlahLab]

Come and join us at GRC Natural Products this summer! We have a fantastic line of speakers from academia and industry. Be a part of the frontiers of science related to the chemistry and biology of bioactive compounds! https://t.co/vrUxAwFyYF

[J. Am. Chem. Soc. @J_A_C_S]

Total Syntheses of Scabrolide B, Ineleganolide, and Related Norcembranoids | Journal of the American Chemical Society @SarlahLab @UofIllinois @ChemistryUIUC @RiceUniversity @TotalSynthesis @TotalSyntheses #Scabrolide #Norcembranoids #Mukaiyama #Michael https://t.co/FJr0oKKSjl

[Sarlah Lab @SarlahLab]

@Conghui_Tang @ListLaboratory It was nice to see you again, Conghui! You and your team are doing an awesome job!

[Sarlah Lab @SarlahLab]

Check our hydroamination of arenes! Adding hydride and nitrogen functionality across arenes has never been so easy.

[Angewandte Chemie @angew_chem]

Copper-Catalyzed Dearomative 1,2-Hydroamination (David Sarlah and co-workers) @SarlahLab #OpenAccess https://t.co/8G13H1Cqt3

[Nature Synthesis @NatureSynthesis]

Now online:

News & Views on the Article by Wen-Xiu Xu, Zhuo Peng, Qing-Xiu Gu, Yao Zhu, Li-Han Zhao, Fucheng Leng & Hai-Hua Lu

https://t.co/JE1dqXBoDR ($)

Hydrogenation streamlines cyclolignan synthesis by David Ryffel & David Sarlah @SarlahLab

https://t.co/qf31iBYfUk ($)

[Sarlah Lab @SarlahLab]

@hanzyduzit Thank you, Hans! We are looking forward to working next to your group! Get those pencils ready for our synthesis boot camp 😉

[J. Am. Chem. Soc. @J_A_C_S]

Oxidative Dearomatization of Pyridines | Journal of the American Chemical Society
@IGBIllinois @SarlahLab @UofIllinois @TotalSyntheses #Dearomatization #Pyridines https://t.co/XIYglX2Cfu

[Sarlah Lab @SarlahLab]

Great collaboration with #PfizerChemistry, showcasing translation of our dearomatization chemistry to pyridines.

[Scott Bagley @BagPhos]

Dearomatization of pyridines is a rapidly evolving method of making functionalized amino-hets
The @SarlahLab in #ChemCollabs with #PfizerChemistry has a new oxidative method now out in @J_A_C_S
https://t.co/iXJFzG063r

[Sarlah Lab @SarlahLab]

@GiuseppeZucca14 @EPFL_en @Echavarren_Lab @FuLabCaltech @CarreiraGroup @snsf_ch Awesome news, Giuseppe! Congratulations! We wish you all the best!

[Sarlah Lab @SarlahLab]

Congratulations to our former member @Conghui_Tang for an awesome paper!

[Angewandte Chemie @angew_chem]

Direct C-C Double Bond Cleavage of Alkenes Enabled by Highly Dispersed Cobalt Catalyst and Hydroxylamine (Conghui Tang and co-workers) @Conghui_Tang https://t.co/nt7NjcFq7t

[Sarlah Lab @SarlahLab]

@SchindlerLab @UBCChem @BCCancer We will miss you, dear "neighbors". But we are very happy for you and looking forward to seeing your great science from Canada and hopefully still have opportunities to interact!

[Sarlah Lab @SarlahLab]

@thestoltzgroup Beautiful dearomatization and very elegant approach! Congrats to the Stoltz group!

[Ingo Hartung @HartungIngo]

David Sarlah (@SarlahLab) closing the day at #EFMCASMC23 (with homefield advantage in #Croatia): Larock cyclization strategy based atropselective synthesis of darobactin A & even more fun with unhealthy looking twisted tricyclic terpenes. Next stop: speaker‘s dinner!

[Sarlah Lab @SarlahLab]

@CornellaLab @LabMurakami @k0j1chem Anytime! Even in December 😉

[Angie R Angeles @angierangeles]

Day 3 ⁦@ACSorganic⁩ #GRS2023 Amazing student presentations: Alexander Oanta (Northwestern Univ), David Ryffel (Univ of Illinois), Jenna Humke (Univ of Minnesota), Matthew McVeigh (UCLA) ⁦@SarlahLab⁩ ⁦@GargLab⁩

[Sarlah Lab @SarlahLab]

It will fit but won't flip! Check out our preliminary collaborative study with @SpiroChemAG and #MerckChemistry, evaluating (very!) rigid Dewar pyridine derivatives as programmable piperidine isosteres. https://t.co/ds4t0au0oP

[J. Am. Chem. Soc. @J_A_C_S]

Total Syntheses of Scabrolide A and Yonarolide @YaroslavBoyko4 @The_Foreign_ @SarlahLab
@ChemistryUIUC @UofIllinois @TotalSyntheses #Scabrolide #Yonarolide #Diterpenes #NiPpentannulation #Methylenecyclopropane #Fragmentation #LiebeskindSroglCoupling https://t.co/oH6n1o3o2Z