Mihir B. Doshi

Scientist | Ph.D. candidate @GSBS_UMassMed in Kim lab, Cancer Biology Program | Alum @Northeastern

[Namgyu Lee @NamgyuLee1]

Our paper has been published today in Nature Metabolism! I extend my sincere thanks to all authors: @SungJin2619, @MikeLangePhD , T. Tseyang, @ScienceGraduate, T.Y. Kim, Y. Song, D.I. Kim, @Greer_Lab , @OlzmannLab , @JBSpinelli , and Dohoon Kim.
https://t.co/1i9yuAvdN3

[UMass Chan Medical School @UMassChan]

“It’s like clogging a drain.” Dohoon Kim, PhD, & colleagues have found a way to poison cancer cells with their waste: https://t.co/B3FVVzVBo2

As published in @Nature. #LungCancer @UMassChanMCCB @UMassCancerCtr @ScienceGraduate @JBSpinelli @KarlSimin @lab_mercurio @MarianWalhout

[Mihir B. Doshi @ScienceGraduate]

@hirenj @Nature @NamgyuLee1 @chrashwood @KarlSimin @cholsoon_jang @lab_mercurio @MarianWalhout @JBSpinelli It is also theoretically possible that aberrant UGT mediates aberrant glucuronidations contributing to toxicity but we did not see any evidence. 2/2

[Mihir B. Doshi @ScienceGraduate]

I'm incredibly thrilled to announce my first-author publication in @Nature . I would like to thank all my collaborators and specially @NamgyuLee1 , @chrashwood , @KarlSimin , @cholsoon_jang , @lab_mercurio , @MarianWalhout, @JBSpinelli my PI and Dohoon Kim.

[Mihir B. Doshi @ScienceGraduate]

@hirenj @Nature @NamgyuLee1 @chrashwood @KarlSimin @cholsoon_jang @lab_mercurio @MarianWalhout @JBSpinelli Hi Hiren, that is an excellent point. Regarding UGTs, we've thought about them but have not looked extensively. They do not seem to comprise a significant 'sink' that consumes the aberrant accumulation of UDPGA. 1/2

[NPR @NPR]

The Senate passed the Sunshine Protection Act which would make daylight saving time permanent across the U.S. beginning in 2023. https://t.co/LGqkCO59kD

[Florian Krammer @florian_krammer]

Great! https://t.co/jQJZ1TfyOL

[CBS News @CBSNews]

.@eric_lander says he’s seen the U.S. take on “amazing challenges” to make the world a better place. Now, he says, “the opportunities we have and the challenges we face are greater than ever before” https://t.co/Be6jNLkMh5

[Sharon B. Cantor @CantorLab]

“It's the gaps, stupid!" Despite the dogma police, we’re not completely broken, just like the DNA: a new model for BRCAness https://t.co/pz0WRSTpsJ from phenom student Nick Panzarino in Cantor Lab.https://t.co/qBoP688n3L

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

[Annie Carlisle @A_Carlisle_19]

Hello SciTwitter, I am proud to share ANOTHER paper out of the Kim Lab today-this time a great review written by my good friends and lab mates @NamgyuLee1 and Meghan, and myself in a supporting role, and advised by Do. Congrats again Kim Lab!🎉 Read here: https://t.co/Q5JWL93Syh

[Mihir B. Doshi @ScienceGraduate]

Selenium metabolism protects them against ferroptotic insults, but a toxic intermediate formed in this process can be exploited to poison them. Congratulations co-first authors
@A_Carlisle_19 , Namgyu Lee and Kim lab.
@NatMetabolism

Read here: https://t.co/cLEpuhCqXQ (2/2)

[Mihir B. Doshi @ScienceGraduate]

Selenium is a micronutrient that is incorporated into selenoproteins via the selenocysteine biosynthesis pathway. The authors describe a two-faced role for selenium in cancer cells (1/2)

[Nature Metabolism @NatMetabolism]

Online now! A micronutrient with major effects on cancer cell viability https://t.co/rvTtNDuzq7

[Annie Carlisle @A_Carlisle_19]

Today I celebrate the publication of the research paper I have worked hard to develop for the past 4 years. Next up, thesis defense- PhD here I come! Most importantly: I could not have done this without my family, friends, and lab mates. Congratulations, Kim Lab! 🎉🎉🎉

[Mihir B. Doshi @ScienceGraduate]

@LizRidesBikes Good luck Liz

[Mihir B. Doshi @ScienceGraduate]

@BrianKelch

[Dena Grayson, MD, PhD drdenagrayson.bsky.social @DrDenaGrayson]

🚨BREAKING: preliminary data from an ongoing clinical study of #remdesivir showed that in 113 patients with severe #COVID19:

▶️Fever/symptoms rapidly improved
▶️Most discharged within 6 days
▶️2 died (1.8%), much less than expected for severe #COVID19

https://t.co/XsgC7ryiri

[Florian Krammer @florian_krammer]

757 people died. Today. In New York City.

People, stay at home!

[David R. Liu @davidrliu]

As expected, data emerges to explain observations of #COVID19 “reinfection”—here, most patients who were ”redetected positive” were actually never truly negative. Plus reinfection cannot be rampant if family members living together successively infect each other but all recover.