Sean Simonini

Neuroscience convert (w/ a public policy past life) | @HSCRB @UMassChanNeuro @NucleateHQ @time_initiative @aginginit

[Sean Simonini @SeanSimonini]

@jeffyfish9 @Afinetheorem @tylercowen @ATabarrok Some exciting announcements stemming from this work soon...

[Jake Becraft @DrSynbio]

Faster and cheaper timelines to first in human. In the United States. EVERYWHERE in the United States (not just coastal KOL hospitals).

Sam nails a number of the parts. And I think this acceleration idea is becoming common place. Let’s get @MartyMakary and @US_FDA on board!

[Sean Simonini @SeanSimonini]

@DrSynbio hits the nail on the head here.

Faster FIH means more access for patients, less money spent per candidate, more shots on goal, and putting American biotech securely back in the lead.

Win. Win. Win. And Win. If the Aussies can do this, so can we.

[Jake Becraft @DrSynbio]

I think this is simple, and similar to what I’ve been discussing with @rtnarch regarding the innovation bottleneck that is first in human (FIH) trials.

Going direct to IRB for FIH will incentivize more phase 1 sites to invest and come on board.

[Sean Simonini @SeanSimonini]

https://t.co/QSd8IPkMXR

[Martin Borch Jensen @MartinBJensen]

Avoiding the Gerontocene means keeping people productive as they age. That requires breakthroughs in longevity.

Push back aging and you get more people, more productive years per person, more workers, more inventors, more parents raising children, more experts with decades of accumulated knowledge still contributing.

The choice between building that future or losing it plays out on a specific timeline. There are two possible versions of 2035, and they look completely different.

Wrote on this with @NornGroup @SeanSimonini @eshanmehra:

[Avery Mizrahi @AveryAMiz]

Awesome talk with Dylan! Such a necessary initiative to get everyone onboard with longevity science.

[Avery Mizrahi @AveryAMiz]

IN THE BOSTON AREA? Come play games for neuroscience and free-will! I'm extremely excited to be collecting data about decision-making under uncertainty at the Whitehead Institute, MIT from Oct-Nov. Please sign up here! https://t.co/gD0pu265y0

[Sean Simonini @SeanSimonini]

Wise words from a wise man @AlexJColville

[Time Initiative @time_initiative]

Want to make a difference in aging biology? Be like a cockroach. Check out our newest episode of the TIMEcast with @AlexJColville who leads @age1vc to find out why. Take a listen here: https://t.co/X3YmGDirVM

[Sean Simonini @SeanSimonini]

Excited to be awarded a $5,000 grant from @ResearchHubF to carry out my work on engineering better cell therapies for CNS conditions. Check out the original proposal here: https://t.co/8sCd6crdHF

[Satvik Dasariraju @satvik_93]

Future of Aging Research Mixer 2025 @aginginit signups now open: https://t.co/28T9uWcQCh

[Martin Borch Jensen @MartinBJensen]

Is the longevity field making progress?
@NornGroup formed in 2021 to address that question. We’ve now built a website to make it clear who we are and how we work to make longevity medicine real. Read on for a summary, and some of our outputs.

[Sean Simonini @SeanSimonini]

I started a substack | "A Return to the Beginning"

https://t.co/rPi6ibzKoA

[Sean Simonini @SeanSimonini]

@NucleateHQ Amazing convo yesterday with these four, talking about how to take new approaches in aging biology, the role of medtech in improving outcomes, promising modalities, and so much more.

Huge thank you to the ~200 people who tuned in!
@AlexJColville @olshav @LNuzhna @slrobinet

[Sean Simonini @SeanSimonini]

Last panel of a great season with @NucleateHQ bringing some of the best minds in Aging Biotech to the people. Register here: https://t.co/ZB5qRSqvrd

[Nucleate @NucleateHQ]

🚀 Join us next week for a dynamic conversation on longevity biotech startups!
On May 12, 2025, Nucleate: Inside Aging welcomes visionary leaders shaping the startup ecosystem in aging and longevity.
💡 Don’t miss out—register today: https://t.co/LLMu4nWYl0

[Sean Simonini @SeanSimonini]

If the Ship of Theseus is rebuilt plank by plank... would the Brain of Theseus be rebuilt neuron by neuron?