Sebastian Niemann

[Sebastian Niemann @SebastianNieman]

@bryan_johnson

[Sebastian Niemann @SebastianNieman]

@bryan_johnson

[Sebastian Niemann @SebastianNieman]

@bryan_johnson Great! Congratulations very impressive and motivating results 👏🫶

[Bryan Johnson @bryan_johnson]

My team and I created a food guide (v1). We based it on evidence, using the heuristic that every calorie must fight for its life.

What do you think?

[Sebastian Niemann @SebastianNieman]

@rakhul @bryan_johnson Absolutely. I was just interested in how the AI assesses the current data situation. And since I live in Germany, I was very happy. Now of course Chat GPT is trained to provide answers that the respective user is satisfied with - so please take my post tongue-in-cheek.

[Sebastian Niemann @SebastianNieman]

@bryan_johnson However, other countries are closing the gap. Germany recently ranked as the best country for entrepreneurship, and nations like Canada and several in Europe are adopting startup-friendly laws and improving conditions. The U.S. is still a powerhouse, competition is intensifying

[Sebastian Niemann @SebastianNieman]

@bryan_johnson I asked Chat GPT whether this is true based on the current data:  America remains a leading place to build, with a strong startup ecosystem, abundant venture capital, and top rankings like StartupBlink’s #1 position globally….

[Bryan Johnson @bryan_johnson]

Kids can’t sleep tonight because they’re too excited for tomorrow morning 🎄. Adults can’t sleep because they’re thinking about all their problems. Soon we’ll all become kids again. Sleep tight.

[Sebastian Niemann @SebastianNieman]

@sternde Wie ätzend ist das denn?! Da ist mal eine Entschuldigung und ein dickes Geschenk fällig.

[Sebastian Niemann @SebastianNieman]

@bootsWieStiefel Wie ätzend - da wäre wohl mal eine Entschuldigung und ein dickes Weihnachtsgeschenk fällig

[Bryan Johnson @bryan_johnson]

the printing press
enlightenment
industrial revolution
flight
personal computer
moon landing
internet
artificial intelligence
don’t die

[Bryan Johnson @bryan_johnson]

On @netflix Jan 1

2025 is the year of don’t die

[Sebastian Niemann @SebastianNieman]

@derspiegel Genau richtig. Diese Diskussion ist nicht nur verfrüht, sondern auch peinlich und würdelos. Als hätten wir hier ein ernsthaftes Problem mit syrischen Geflüchteten, außerhalb der einen oder anderen Bubble.

[@ChrisStoecker @ChrisStoecker]

Kolumne: Die #FDP hat Öffentlichkeit und Medien wochenlang absichtlich in die Irre geführt. Öffentliches Lügen ist aber auch in anderen Parteien weitverbreitet. Das ist eine große Gefahr für Demokratie, Gesellschaft und Wirtschaft - sagt die Wissenschaft. https://t.co/lLQrGMQ6GB

[Sebastian Niemann @SebastianNieman]

@bryan_johnson Thank you for this important update and the great work with your team. 🙏🫶🖖

[Bryan Johnson @bryan_johnson]

On September 28th, I decided to stop rapamycin, ending almost 5 years of experimentation with this molecule for its longevity potential.

I have tested various rapamycin protocols including weekly (5, 6, and 10 mg dose schedules), biweekly (13 mg) and alternating weekly (6/13mg) to optimize rejuvenation and limit side effects.

Despite the immense potential from pre-clinical trials, my team and I came to the conclusion that the benefits of lifelong dosing of Rapamycin do not justify the hefty side-effects (intermittent skin/soft tissue infections, lipid abnormalities, glucose elevations, and increased resting heart rate). With no other underlying causes identified, we suspected Rapamycin, and since dosage adjustments had no effect, we decided to discontinue it entirely.

Preclinical and clinical research has indicated that prolonged rapamycin use can disrupt lipid metabolism and profiles [1], as well as induce insulin and glucose intolerance [2] as well as pancreatic Beta-cells toxicity [3]. Despite anecdotal evidence of rapamycin slowing down tumor growth, its effect in inhibiting natural killer cells [4]  do raise concern for anti-cancer immune surveillance and cancer risk in the longer run.

Additionally, on October 27th, a new pre-print [5] indicated that Rapamycin was one of a handful of supposed longevity interventions to cause an increase/acceleration of aging in humans across 16 epigenetic aging clocks. This type of evaluation is the first of its kind, as most longevity interventions up to date have been tested against one or two aging clocks, leading to invisible biases and potential intended “cherry picking” of favorable clocks for the tested interventions.

Longevity research around these experimental compounds is constantly evolving, necessitating ongoing, close observation of the research and my biomarkers which my team and I do constantly.

Sources:
[1] https://t.co/clXah1mOuc
[2]https://t.co/mSlnpOYJRg.
[3]https://t.co/05ljueNWOM
[4]https://t.co/NIdYwzEilk.

[Sebastian Niemann @SebastianNieman]

@MarkHamill

[Sebastian Niemann @SebastianNieman]

@CalltoActivism

[Misha Collins @mishacollins]

Harrison Ford has always been a hero of mine, but I’ve never admired him more.