Idan Segev

Professor of Computational Neuroscience at @ELSCbrain @HebrewU

[Netanel Ofer @NetanelOfer]

Introducing the “biophysics of connectomics”, bridging 3D EM reconstructions and biophysical modeling.

Ultra-thin spine-neck constrictions act as electrical bottlenecks, driving ultra-fast EPSP dynamics.

Great teamwork with @SapirShapira2 and @Segev_Lab
https://t.co/qM4wBcl2GK

[Idan Segev @Segev_Lab]

Our insights from years of modeling human neurons. Come read our new review, now on @FrontNeurosci

[Ido Aizenbud @IdoAizenbud]

What makes human pyramidal neurons uniquely suited for complex information processing? How can human neurons’ distinct properties contribute to our advanced cognitive abilities?

[Ido Aizenbud @IdoAizenbud]

Human cortical pyramidal neurons are larger, exhibit more complex branching patterns, and feature distinctly nonlinear biophysical properties compared to rat cortical pyramidal neurons.

Do these unique characteristics make human neurons more functionally complex?
Would that enhance the capability of the human brain to perform complex computational tasks?
Is this what makes us human?

In our new preprint (see below) with @danielayoeli, @DavidBeniaguev, Christiaan de Kock, @mikilon, and @Segev_Lab we use deep learning to tackle these questions by comparing the complexity of neurons’ input-output (I/O) functions using our newly developed Functional Complexity Index (FCI) tool. (1/10)

[Toviah Moldwin @TMoldwin]

What makes us human? A new review from my colleagues at the @Segev_Lab discusses how neuronal modeling can help answer this question.

https://t.co/fM8C0lG7V5

[Idan Segev @Segev_Lab]

Will be interesting to hear Christof Koch on "Beyond physicalism - consciousness, quantum mechanics, and mystical experiences."

[Mickey London @mikilon]

Neuroscience Unleashed in Jerusalem July 20–24 2025
An international graduate school on consciousness, NeuroAI, brain-machine interfaces, psychedelics & organoids. Graduate students & postdocs: Apply by April 19 2025 https://t.co/dsv8TGWZ3W
RT to help spread the word 🙏

[EPFL Blue Brain Project @BlueBrainPjt]

Read the paper- Chindemi et al 2022 - A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex - https://t.co/smufewpMWP published in @NatureComms

Find out more - https://t.co/lKoB6L3GND

#plasticity #insilico

[Idan Segev @Segev_Lab]

@DavidBeniaguev et al. show that “dendro-plexing” of the presynaptic spike due to dendritic cable filtering of distal vs. proximal synapses, combined with multiple synaptic contacts, both “saves” axonal wiring and boosts the memory capacity of neurons.

@mikilon @SapirShapira2

[David Beniaguev @DavidBeniaguev]

A new preprint about how adding dendrites can potentially explain the phenomenon of multiple synaptic contacts between neurons in the brain:

bioRxiv: https://t.co/VnCG527kfc

With @sapir_shap @mikilon @Segev_Lab

[Toviah Moldwin @TMoldwin]

My band, @SynfireChain, released our first single! Then we played it to a zebrafish under a microscope with
@LilachAvitan @ELSCbrain and put the calcium imaging video of its brain as the background to the lyric video. Because #science.

https://t.co/IksVsjM8Sw

[Idan Segev @Segev_Lab]

Join us for an exciting series of talks with @YMalchi, in Beit Ariela featuring @Amiramedi, Prof. Sarit Larish, @YovelBatLab, @MeravAhissar and myself. Details inside -

[פרונטירז - מדע לצעירים @FrontYoung_IL]

לא רק בכתב! 📣😀🗨️
הצטרפו אלינו לסדרה של חמישה מפגשים בהנחיית @YMalchi המפגישה את הילדים והילדות שלכם עם החוקרים מאחורי המאמרים (ללא תשלום, דורש רישום) - https://t.co/r5DbfY4ueqמדע-ללא-גבולות/
@Segev_Lab @Amiramedi פרופ' שרית לריש @YovelBatLab @MeravAhissar

[Idan Segev @Segev_Lab]

I am heading a fascinating endeavor - @FrontYoung_IL, a scientific journal for kids, written by prominent scientists and reviewed by kids! This exciting and unique format allows direct interaction between scientists and kids, benefiting both sides.
Follow us on twitter!

[פרונטירז - מדע לצעירים @FrontYoung_IL]

קצת עלינו -
מי אנחנו? כתב עת בינלאומי מדעי מקוון לילדים. 👩‍🔬🧪📘🧑‍💻
הכותבים שלנו הם מדענים מובילים מהארץ והעולם. אנחנו מאמינים שהדרך הטובה ביותר להנגיש תגליות מדעיות לצעירים היא לאפשר להם לעבוד יחד עם המדענים, ולכן כתב העת *נערך על ידי ילדים*.
https://t.co/gJ8Ux2OsUc
1/4

[Eilam Leleo Goldenberg @EilamLeleo]

In our paper Burst Control, we explore the synaptic input conditions leading to spike burst firing in layer 5 pyramidal cells
https://t.co/FwS669zkfN

@Segev_Lab
@ELSCbrain

[Idan Segev @Segev_Lab]

New paper from our lab in collaboration with the BBP.

[EPFL Blue Brain Project @BlueBrainPjt]

New paper from Blue Brain & the Hebrew University of Jerusalem.
The study uses one of the most detailed models of a piece of brain tissue & modern network science & systematically studies the impact of cell types on network activity in health and disease
https://t.co/pfC7ZejpoT

[Idan Segev @Segev_Lab]

A new paper by @DavidBeniaguev from my lab. and that of @mikilon using machine learning approach to systematically quantify and compare how "computationally deep" are different neuron types.

[David Beniaguev @DavidBeniaguev]

Out work about "Single Cortical Neurons as Deep Artificial Neural Networks" was finally published in Neuron

With @mikilon and @Segev_Lab

@NeuroCellPress paper: https://t.co/XOrRxVVEjO
code: https://t.co/IGH8DmCucr
data: https://t.co/QswJsD5zfV

All new results in thread below

[Toviah Moldwin @TMoldwin]

My and @MMKalmenson's #GradientClusteron paper is out in PLOS CB! Learn how a model #neuron with a single #dendrite can solve #MachineLearning tasks by making synapses attract and repel with a gradient descent rule! With @Segev_Lab and @ELSCbrain.

https://t.co/wl4rvwzGT8

[Eilam Leleo Goldenberg @EilamLeleo]

In our paper Burst Control, we model the L5PC and analyze the conditions of synaptic activation in the apical and basal dendrites for burst generation. We found a novel burst-class, defined inhibitory control and correlated it with limiting plasticity.

https://t.co/Pvhqwtakuv

[Idan Segev @Segev_Lab]

New paper from the lab. The G-clusteron is a model neuron with a single "dendrite" where synapses exhibit distance-dependent multiplicative interactions with each other. It can learn tasks like MNIST via a gradient descent algorithm which makes synapses attract\repel.

[Toviah Moldwin @TMoldwin]

The Gradient Clusteron paper with @MMKalmenson and @Segev_Lab is up on biorXiv!

https://t.co/hKq0UcOkbE

Constructive feedback is appreciated!

[Nadav Yayon @YayonNadav]

So, I am Happy to share this central effort from my PhD.
Pop-Rec is a high throughput method for unbiased, completely automated reconstruction of thousands of neurons from cleared mouse brains.
https://t.co/m6YpCdl7Ab

[Nadav Yayon @YayonNadav]

This new version, allows normalization between samples, reducing experimental variability (assuming assumptions are met!). We used this MATLAB based tool (sorry @FijiSc users :( ) to correct 2-Photon, Light-Sheet and confocal datasets.

[ELSC Brain @ELSCbrain]

Beautiful thread by @Oren_Amsalem from @Segev_Lab explaining his work! He and his colleagues used a detailed model of the neocortex to obtain cell-type-specific insights on stimulus specific adaptation (SSA) in the auditory cortex.
Read it at https://t.co/rJqpaPYMac

[Oren Amsalem @Oren_Amsalem]

Replicating experiments in a supercomputer can help us understand the brain
1) We replicated auditory experiments (usually of rat/mice) on a detailed model of the neocortex and discovered novel mechanism for the phenomena observed in the experiments
https://t.co/i4ngKX6dOL
THREAD