Sehgal Path Lab

Blood Testing lab Hematopathology Speciality Laboratory with focus on Bone Marrow, Flow Cytometry , Cytogenetics and Molecular Diagnsotics

[Sehgal Path Lab @SehgalPathLab]

Great start to 2021 for team @sehgalpathlab for having their B-MRD paper published today in @PHOJournal. Special thanks to Reviewer 2 for all his efforts in improving the article and taking it to the next level @DrGauravNarula

[Kunal Sehgal @drkunalsehgal]

Very happy to share our paper published in PediatricHematologyOncologyJournal today on our experience of MRD detection in B-ALL.https://t.co/oaH24EGI0i We describe various factors which impact sensitivity of MRD assay & highlight the need for standardisation of B-MRD assay

[Sehgal Path Lab @SehgalPathLab]

Not everything attractive is harmless. Unmask the truth behind tobacco and choose freedom over addiction.

#sehgalpathlab #worldnotobaccoday #saynototobacco #quitsmoking #quittobacco @drkunalsehgal

[Sehgal Path Lab @SehgalPathLab]

Not everything attractive is harmless. Unmask the truth behind tobacco and choose freedom over addiction.

#sehgalpathlab #worldnotobaccoday #saynototobacco #quitsmoking #quittobacco

[Sehgal Path Lab @SehgalPathLab]

Only 3 Days Left! ⏳

Don’t miss the special Neu Life Check – Women Basic Package at just ₹2500
Offer valid till 31st May 2026 only!

Home collection all over Mumbai - 02235193900

Because she takes care of everyone, it's time someone takes care of her.

#sehgalpathlab #mother

[Sehgal Path Lab @SehgalPathLab]

Diabetes doesn’t always begin loudly.
Sometimes, your body whispers first.

Constant fatigue.
Unusual thirst.
Slow healing.
Frequent cravings.

The signs may seem small-until they aren’t.

Early testing can make all the difference.

Get tested. Stay ahead.

#sehgalpathlab

[Sehgal Path Lab @SehgalPathLab]

May this Eid bring peace, happiness, and prosperity to you and your family. Eid Mubarak!

#sehgalpathlab #festivals #festivalsofindia #eidmubarak

[Sehgal Path Lab @SehgalPathLab]

Kickstart your career in cytogenetics with hands-on clinical training at Neuberg Sehgal Path Lab.

Gain real lab exposure, advanced diagnostic skills, and a strong foundation in Hematology & Oncology.

Limited seats - Apply now - [email protected]

[Sehgal Path Lab @SehgalPathLab]

The greatest mom? Every mom.

We asked kids about their moms and realized one thing: different moms, same unconditional love.

At Neuberg, we believe best way to honour that love is by protecting their health. Happy Mother’s Day to the heartbeat of every home!

#sehgalpathlab

[Sehgal Path Lab @SehgalPathLab]

Exclusively at Our Collection Centres mentioned below -

🔹 FOUR BUNGALOWS
Neuberg Sehgal Path Lab, 003, Ground Floor, Yashodhan Building 2, JP Rd, Andheri W, Mumbai 53
🔹 YARI ROAD, VERSOVA
Neuberg Sehgal Path Lab, Shop No.5, Silver Sands, Palm Beach, Yari Rd, Versova, Mumbai 61

[Sehgal Path Lab @SehgalPathLab]

NEUBERG HEALTH SATURDAY

Champions stay prepared — so should you!

Winning starts with staying healthy.
Stay fit. Stay ahead.

Join us for our Mega Health Camp on:

📅 9th May, Saturday
⏰ 08:00 AM onwards

[Sehgal Path Lab @SehgalPathLab]

Special Camp Rates starting from Rs 20 only /- with many discounted health packages

📞 For details: 022-35193900

[Sehgal Path Lab @SehgalPathLab]

Because she takes care of everyone-it's time someone takes care of her. #sehgalpathlab #mothersday #happymothersday #motherhood #bestmomever

[Sehgal Path Lab @SehgalPathLab]

She checks everything… just not herself. This Mother’s Day, remind her to choose her health.

Introducing Neu LifeCheck – Women Basic.

Special Price: ₹2500 (MRP ₹9014)
Offer valid till 31st May 2026

Home collection all over Mumbai - 022-35193900

[Henry C Fung| MM, lymphoma, leukemia & CART @HenrychihangFu1]

Many of us misunderstand KMT2A leukemia.
FDA says “translocation”—biology says fusion.
FISH ≠ partner. DNA panels miss it.
Only KMT2Ar responds.

Break-apart tells you that.
RNA tells you what.
Biology tells you if it matters.

[Henry C Fung| MM, lymphoma, leukemia & CART @HenrychihangFu1]

TP53 in MDS is not binary.
It’s a spectrum.

And we’re oversimplifying it !

Large SCT dataset confirms:

• TP53-mut = adverse
• “Biallelic” = worst

Important work.
But the biology is more nuanced.

Monoallelic TP53?

Bad.
But how bad?

We all have long-term SCT survivors →
👉 suggests residual function / heterogeneity

True biallelic (multi-hit)?

• Functional TP53 loss
• Genomic instability
• Near chemo-resistant state

👉 Very difficult to rescue, even with SCT

But here’s the issue:

“Biallelic” often defined as VAF >50%

👉 Useful shortcut
👉 Not biology

VAF >50% ≠ biallelic

VAF reflects:

• Tumor purity
• Clonal dominance
• Copy number

A dominant monoallelic clone
can look like “50%”

More importantly:

👉 What if TP53 is a 10% subclone?

Different biology:

• Less genomic dominance
• Less clonal fitness

👉 GVL may still control this

So TP53-mut disease is not one entity:

• Monoallelic dominant
• True multi-hit
• Small subclonal TP53

➡️ Different biology
➡️ Different outcomes

Retrospective studies like this are critical
—but limited by simplified definitions

TP53 is a spectrum
VAF is not allelic state

True biallelic = genomic collapse

Subclonal TP53 → may be GVL-sensitive

See figure 👇

Dr Fun + G

#MDS #AML #Hemetwitter

[Henry C Fung| MM, lymphoma, leukemia & CART @HenrychihangFu1]

@JMaakaron Thank you.

MYC rearranged ≠ Burkitt

WHO5 / ICC:
• Burkitt → MYC-R + classic biology
• DH/TH → MYC + BCL2/BCL6
• HGBL-NOS → MYC-R, no partner
• DLBCL can still be MYC+

Clinical truth:
MYC = high-grade behavior signal

[Sehgal Path Lab @SehgalPathLab]

Kickstart your career in cytogenetics with hands-on clinical training at Neuberg Sehgal Path Lab.

Gain real lab exposure, advanced diagnostic skills, and a strong foundation in Hematology & Oncology.

Limited seats - Apply now - [email protected]

[Sehgal Path Lab @SehgalPathLab]

#sehgalpathlab #worldhealthday #healthyhabits #neubergdiagnostics #7daysofhealth #healthawareness

[Sehgal Path Lab @SehgalPathLab]

Good health is built on small, everyday choices. So we asked our team to share the one habit they never skip. Because it’s these simple, consistent habits that quietly build long-term health and wellbeing.

Tell us one health habit you never skip in the comments below.

[Sehgal Path Lab @SehgalPathLab]

#sehgalpathlab #neubergdiagnostics #7daysofhealth #healthawareness #preventivehealthcare #hearthealth

[Sehgal Path Lab @SehgalPathLab]

Instead of guessing online, let the right test guide you.​ Dr Prajwal explains why the Lipoprotein (a) test is important, especially for understanding inherited heart risk and taking timely preventive steps.​

Book a home visit today: ​
📞 022-35193900