SeulAh Kim

Neuroscience PhD candidate in the Sabatini lab | @PiN_Harvard

[SeulAh Kim @SeulAhKim2]

Can it get more contradictory than this - two opposing neurotransmitters packaged into the same vesicles ☯? In our new @blsabatini lab paper, we show co-packaging of glutamate:GABA in individual vesicles! (1/n) https://t.co/6C5i8hVfvi

[SeulAh Kim @SeulAhKim2]

Beautiful story! Congratulations @shunnnli and the team for the impactful discovery 🙌🙌

[Shun Li @shunnnli]

Can synapses in the brain switch their signs between excitatory and inhibitory during learning🚦?

Can they act more like weights in artificial neural networks, able to switch signs based on experience 🔃?

Excited to share my thesis work in @blsabatini lab!

🧵 ⬇️ (1/13)

[Lynne Chantranupong @Lchantran]

I am thrilled to join @BU_Biology as an Assistant Professor in January 2024!! Looking forward to pursuing exciting questions in neuronal cell biology and metabolism! Find out more here: https://t.co/HzyJxHnSx7 We are recruiting curious and motivated trainees to join our team!

[Wallace Lab @WallaceLab1]

Please check out our new review of multitransmitter neurons! We tried to focus on recent advances and technology that allow their study at the single synapse level.
https://t.co/If0VIgaSsI

[SeulAh Kim @SeulAhKim2]

It's been a pleasure to work on such a cool project with @blsabatini and @WallaceLab1. Thanks to both for the guidance and constant support along the way! 🏃🏻‍♀️🏄🏻‍♀️

[Bernardo Sabatini @blsabatini]

Today we in @SabatiniLab proudly celebrate freshly minted Dr. Seul Ah Kim @SeulAhKim2 whose thesis work proved that GABA and glutamate are copackaged in the same vesicles at EP to LHB synapses. Congrats on your great work and defense!

[Laura Driscoll @lndriscoll]

🚨⏰ 🚨 #TWEEPRINT TIME 🚨⏰ 🚨

💫🎊🥳My postdoc work is now online! 🎉🌝💫

@shenoystanford @SussilloDavid and I have been working to understand how neural networks perform multiple related/interfering computations using the computation through dynamics framework.
1/15

[Max Wilkinson @maxewilkinson]

1/5
My first postdoc paper! We found a new viral defence system in bacteria that looks suspiciously similar to inflammasome and apoptosome proteins from fancy eukaryotes – and indeed it acts as a true pattern-recognition receptor to detect phage proteins
https://t.co/iapgZNpkwY

[Alexander Bates @as_bates]

With @gsxej, we wrote a dispatch (https://t.co/xuwpVA7xFU) on @Christa_A_Baker @MurthyLab @FlyWireTweet's auditory system paper, and tried to use their study to show that Drosophila neuroscience is now fulfilling an early dream, connecting the systems and mechanistic approach:

[SeulAh Kim @SeulAhKim2]

@idoneuroscience Congrats!!!! 💃🏻

[Rich Hakim @RichieHakim]

Hello calcium imaging twitter, I have a thread for you. We made a self-supervised network that is great at ROI classification and tracking over sessions.
If you do calcium imaging, it'll probably save you time.
Help me improve it. Send your ROI masks to: [email protected]

[HarvardBrainScience @harvardbrainsci]

Neuronal Communication With Opposing Signals
@SeulAhKim2
@blsabatini

https://t.co/KVcBWJDMYt

[SeulAh Kim @SeulAhKim2]

@ErikMaronde @blsabatini Glutamate current arrives a bit earlier than GABA current, so you are absolutely right! Depending on the shape of the biphasic current, it can generate interesting firing patterns in the downstream neurons🤩

[SeulAh Kim @SeulAhKim2]

Can it get more contradictory than this - two opposing neurotransmitters packaged into the same vesicles ☯? In our new @blsabatini lab paper, we show co-packaging of glutamate:GABA in individual vesicles! (1/n) https://t.co/6C5i8hVfvi

[SeulAh Kim @SeulAhKim2]

@ChongGuo6 @blsabatini great idea! 🙃

[SeulAh Kim @SeulAhKim2]

@StephRudolphLab @blsabatini yes, I remember those days! 😂

[SeulAh Kim @SeulAhKim2]

@JasmineKwasa @blsabatini Thanks Jasmine! That's an amazing coincidence 😃

[SeulAh Kim @SeulAhKim2]

It’s been a really fun project to work on. Thanks @harvardmed, @blsabatini, and other talented members in the Sabatini lab. You can find more detail on the technique and math in the paper. Codes for simulation and data analysis are publicly available: https://t.co/8tI1oWNauU

[SeulAh Kim @SeulAhKim2]

What’s cool is that co-packaging simplifies the task for the downstream neurons. Since both transmitters are delivered reliably, perhaps each neuron can simply choose a different sign and synaptic weight for this connection between the input-output layers, like with some ANNs!