The Wilkinson Lab is open for science! @MSKCancerCenter
๐งฌWe'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)๐งฌ
@OliBClarke @EMDB_EMPIAR@kimanius@SjorsScheres alternatively, people might just discover I'm a bit rubbish at processing cryoEM data ๐ฌ
But this dataset was definitely challenging for me, at least!
PS if someone in the Boston area spots a spare printed copy in their department tearoom could they please steal it for me ๐๐๐๐ (steal one for yourself first of course)
covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting
(Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)
The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA.
In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative pathways to making genes from RNA that did not previously encode proteins. Learn more this week in Science: https://t.co/MT1Bhru2Ox
@Bryce_Nickels Correct! The reconstituted promoter is a 100% perfect match to that consensus, spacing and all. It's a better match to the consensus than most natural promoters. (This definitely gave us more hope in the hypothesis early on!)
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.
(๐ I recommend sound ON for the video ๐น)
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Such a crazy discovery. I think this captures the reaction of the audience while watching @maxewilkinson present this at the Symposium on the Immune System of Bacteria.
Lots more in the paper (#cryoEM etc!)
https://t.co/IrVR3JkLJY
Big thanks to coauthors @_David_Li@algao8 Rhiannon Macrae and @zhangf
Please also check out @shsternberg@stephentang23 related work - we come up with similar models, but it'll be exciting to resolve the differences!
Nils's incredible work is finally out, amazing work on a multi-talented protein by a multi-talented postdoc! It was a joy to use Dari @kimanius 's new Blush algorithm in #RELION to solve the cryoEM structure of this 40 kDa RNA complex
๐๐ป I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published in @Nature. ๐ฅณ This unassuming little helixโturnโhelix protein packs quite the punch! ๐งถ๐๐ป
https://t.co/G1980lKFtx
In our newest preprint,
โข we explore the effects of synonymous genome recoding, and
โข construct & troubleshoot a synthetic 57-codon E. coli genome using multi-omics, editing, and laboratory evolution.
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