Drug-induced liver injury has always been a burden on drug development, calling for better in vitro liver models. In this study, we combined a protocol for developing human liver organoids from iPSCs and a microfluidic “chip” system towards that goal.
We are happy to announce our SARS-CoV-2 drug repurposing screen has just been published in PNAS! This was a massive team effort that would not be possible without many, including @ChristianeWobus@TheSpenceLab@ArulChinnaiyan@momeara
https://t.co/fPRUm3p0lx
As #COVID19 manifests differently in different tissues we study their effects on a wide variety of cell lines. Cardiomyocytes are particularly interesting because you can watch them beat! Great work from Carla, @psychsiren!
Needed a physiological lung model, so I made one in an “organ-on-chip” system grown with @tristanfrum’s airway basal cells. Air flow and stretch applied to mimic breathing results in mucosal and ciliated cells. Hope to validate this for #COVID19 and other diseases! @SextonLabUM
@CaymanChemical Always making research possible! We used your FDA approved compound library to find drugs that can help fight SARS-CoV-2! Thank you for your help from a former Cayman Chemical intern under Holly Pierzynski and Nathan Layle! @SextonLabUM https://t.co/SSPoFXXrNl
Our Covid19 drug repurposing screen found 15 FDA-approved drugs and the dietary supplement Lactoferrin have strong antiviral effects in vitro: https://t.co/AcyTd405al
Check out our collaborative study with Dr. Rishel Vohnoutka where we used @CellProfiler to quantitate cytoskeletal structure using radial distribution of intensities! On cover of MBoC - https://t.co/imrsAl6CNR
Hello world! Tomorrow marks the beginning of U of M Drug Repurposing. Please join us at our Town Hall where we will be introducing our services. Details: https://t.co/OmTY5zZUb2