Jason Spence

Studying stem cells, development and disease. Opinions are my own.

[Eric Topol @EricTopol]

We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is fortunately rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. @umichmedicine @UMRogelCancer
https://t.co/Wl3Ys6kkzJ @CD_AACR

[The Fuchs lab @ElaineFuchsLab]

Our paper is out in @ScienceMagazine
Here we describe how stem cell retain epigenetic inflammatory memory long-term. Full text in the link below!
Congratulations @chris_cowley14 @SairajSajjath @LFSoto12 and everyone else involved!
https://t.co/G2MLNwTh6D

[Jason Buenrostro @JD_Buenrostro]

It’s well known that inflammation increases cancer risk, but how?

The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.

Here is our paper: https://t.co/FcnkLdpiKZ
And a special shoutout to the lead author @snaga13

A 🧵

[Jason Spence @TheSpenceLab]

@TanentzapfLab @TanentzapfLab - I was inspired by this post, and just sent my first email reply (of many?) saying that the document looked good and feel free to sign on my behalf!

[Keith Siau @drkeithsiau]

Villi and its microvilli

[Fusion Conferences @Fusion_Conf]

🚨Don't forget to secure your place at our new conference!
3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract
📆 Date: 10 Jul - 13 Jul 2026
📍 Location: Lisbon, Portugal
📢Early Bird & Talk Submission: 07th May 2026
Don't miss out, Register now: https://t.co/hACVmQpDUB
#FusionDevBio #FusionStemCells

[Jason Spence @TheSpenceLab]

@ChanZuckerberg We identified two transcriptional states for alveolar AT2 cells. Using spatial transcriptomics, we found that AT2 cell states reside in specific niches (neighborhoods), interact with distinct alveolar fibroblast subtypes and are driven by inflammatory/anit-inflammatory signals.

[Jason Spence @TheSpenceLab]

Excited to share our newest preprint, "Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung".

Led by Tristan Frum with funding from the @ChanZuckerberg Pediatric Network.

https://t.co/i0fucaxWg4

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung
https://t.co/QHR2V8I6bp @TheSpenceLab @UMichMedSchool

[Jason Spence @TheSpenceLab]

New #organoid preprint from the Spence Lab, the Translational Tissue Modeling Laboratory (https://t.co/BGl1rw3CZB) in collab with @jonnysexton @SextonLabUM

A scalable long-term in vitro model of human colonic epithelium with continuous barrier function

https://t.co/pJgI7YRs8g

[Jason Spence @TheSpenceLab]

Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development

https://t.co/6EC6M7MVkP

A companion piece to our recent work from my colleague Kate Walton, led by Kelli Johnson and Xiangning Dong!

[Jason Spence @TheSpenceLab]

Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids!

We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine.
https://t.co/rzSfsdGhjO

[Jason Spence @TheSpenceLab]

@KrishnaswamyLab @Yale @YaleEngineering @YaleMed @YaleGenetics @YALECS Congrats Smita!

[Waggoner Lab @LabWaggoner]

Impaired stromal-epithelial cross-talk in Hirschsprung disease highlights the risk of epithelial damage, suggesting a therapeutic option
https://t.co/ZLdlmeOrIW @ScienceTM

[Jason Spence @TheSpenceLab]

Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids!

We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine.
https://t.co/rzSfsdGhjO

[Lilly Oncology Medical @LillyOncMed]

🔬Advances in Precision Medicine underscore the importance of 🧬biomarker-informed care in NSCLC.

Learn how upfront NGS testing can provide the most comprehensive biomarker information, while also reducing overall cost and time to results: https://t.co/mUHaW4XWun

[Gray Camp @GrayCampLab]

Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 https://t.co/VKQtZ3LMaW

[Waggoner Lab @LabWaggoner]

Recent evolution of the developing human intestine affects metabolic and barrier functions @ScienceMagazine @GrayCampLab @TheSpenceLab
https://t.co/uot3FLrgLK

[Simone Sidoli @SimoneSidoli]

We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us!
https://t.co/3beLRHphKU

[Peggy Hsu MD PhD @PeggyPHsu]

So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way!

BWF Announces 2025 Career Awards for Medical Scientists https://t.co/IcqwekZCxL

[Gray Camp @GrayCampLab]

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: https://t.co/HntzSYo9zF Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research