Sharon Lagas

[Sharon Lagas @SharonLagas]

@rheault_m Sending you blessings for a quick recovery ❤️‍🩹

[Alport Syndrome Foundation @AlportSyndFndn]

Our most recent e-newsletter includes a Treatment Medications Guide for adult #Alportsyndrome patients, research updates, news about @TalarisTx’s #FREEDOM1/#FREEDOM2 trials, and more. https://t.co/usJLfwHoid

[Michelle Rheault @rheault_m]

Happy new year everyone! 🍾

Time for the top 10 stories of the year in #Alport syndrome. (Unscientifically according to me). 🧵If you didn't know there were more than 10 stories, you haven't been following me long enough.

[Sharon Lagas @SharonLagas]

@rheault_m @UMNFamilyMed Congrats!

[Sharon Lagas @SharonLagas]

@WaltDisneyWorld shame on you for selling so many tix and not having the resources in place to handle this many people! #WaltDisneyWorld #neveragain

[Sharon Lagas @SharonLagas]

This is NOT the happiest place on earth @WaltDisneyWorld you can do better!

[Asheeta Gupta 🩺 @asheetagupta]

Important take home@messages from @rheault_m! Could not agree more!#womeinnephro #kidneyweek #ASNKids22 @ASNKidney

[AJKD @AJKDonline]

From our Pregnancy and Kidney Disease special collection:

Pregnancy and CKD: Advances in Care and the Legacy of Dr Susan Hou

https://t.co/Ed1TR28WDa (FREE temporarily)

@AndreaOliverio @KateBramham @hladunewich
#kidneydisease #pregnancy

[Cathy Quinlan #KidneyWk @KidneyCathy]

Take home points from @rheault_m Crucially XX females are patients too and not “just” carriers. #kidneywk @womeninnephro

[Cathy Quinlan #KidneyWk @KidneyCathy]

Crazy to think that a 40% incidence of kidney failure by the age of 60 was dismissed as mild! Genotyping can allow for better prognostication but we still need to actually find these women and not just focus on XY males with COL4A5 disease.
@rheault_m #kidneywk @womeninnephro

[Cathy Quinlan #KidneyWk @KidneyCathy]

X-linked kidney disease in XX females - it all starts with random lionisation of the X chromosome - which copy will be switched off?
@rheault_m @womeninnephro #kidneywk

[Sol Carriazo, Neph. @Nefrontera]

Great talk by @rheault_m at #KidneyWk about X-Linked kidney diseases in XX patients.

Do not forget that:

✅Women with X-Linked kidney disorders are not "carriers"

✅ALL women and girls at risk of X-linked kidney disorders should be screened for signs and symptoms

[Michelle Rheault @rheault_m]

Dr @DannyGale_1 states that “An incorrect genetic diagnosis is worse than no diagnosis.” #KidneyWk

[Michelle Rheault @rheault_m]

Lessons learned from Early Protect trial. #KidneyWk

[Michelle Rheault @rheault_m]

Final speaker, Dr Oliver Gross on Alport therapies in development. #KidneyWk Treatment with ACEi is important, but only slows progression not a cure.

[Michelle Rheault @rheault_m]

Dr Miner uses the analogy of chapters in a book to describe an exon skipping approach to treating Alport mutations. #KidneyWk

[Michelle Rheault @rheault_m]

What if we express the alpha556 trimer in podocytes? Can this make up for absent alpha345? #KidneyWk

[Michelle Rheault @rheault_m]

Next speaker is @JeffMinerPhD. #kidneywk Starts with images from his Alport mouse model “that was made before some of you were probably born”. 🐁

[Michelle Rheault @rheault_m]

Many international registries of Alport syndrome. In addition, my Alport Syndrome Treatment and Outcomes Registry @UMNPeds with >700 patients. Encourage your patients with Alport syndrome in the US to register. https://t.co/QZlTYOvv6l

[Michelle Rheault @rheault_m]

A patient’s experience of Alport syndrome doesn’t end with the kidneys and ears. #kidneywk https://t.co/OZoNFyjuqi