Shiekhattar Lab

@SylvesterCancer @Univmiami

[nature @Nature]

Nature research paper: RNA N-glycosylation enables immune evasion and homeostatic efferocytosis

https://t.co/aNL1ocWSde

[Nature Methods @naturemethods]

For a quick summary, read the Research Briefing here:

https://t.co/lbdFqZRUhy

[Molecular Cell @MolecularCell]

Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA https://t.co/6fB20s9EFJ

[Shiekhattar Lab @ShiekhattarLab]

Our new paper is out on @MolecularCell !!

We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs.

https://t.co/Z3377dDfTE

#StemCells #Transcription #DevelopmentalBiology #RNApolII

[Shiekhattar Lab @ShiekhattarLab]

Honored to contribute to this work with @DrSDNimer.

#TAF1 #Hematopoiesis @Dev_Cell @SylvesterCancer

[Sylvester Comprehensive Cancer Center @SylvesterCancer]

🔬 Science meets leadership. As director of Sylvester, @DrSDNimer leads a powerful network of researchers, physicians and patients while continuing his own work in the lab.

In his latest study, Dr. Nimer and colleagues uncovered how a key molecule, TAF1, regulates hematopoiesis. Their discovery opens the door to potential new therapies targeting TAF1.

➡️ The findings were published July 16 in @Dev_Cell. Read more: https://t.co/ktvRRjdugt

[Shiekhattar Lab @ShiekhattarLab]

We also uncover a key role for INTS11 in neurodevelopmental gene regulation.

[Shiekhattar Lab @ShiekhattarLab]

We introduce rPRO-seq, a rapid and low-input method to map nascent RNA with nucleotide precision — in just 12 hours and from as few as 5,000 cells.

https://t.co/z56RvcTwBT

#RNA #Genomics #PROseq #NascentTranscription #Neurodevelopment #MolecularCell

[bioRxiv Molecular Biology @biorxiv_molbio]

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks https://t.co/fD5hcqr65d #biorxiv_molbio

[Shiekhattar Lab @ShiekhattarLab]

Explore emerging #CancerEpigenetics #CancerTherapy #Epigenomics research with field leaders @KeystoneSymp Epigenetic Mechanisms and Cancer Treatment, this February in Santa Fe! https://t.co/4vG8ri9oCb #KSCancerEpi24

[Shiekhattar Lab @ShiekhattarLab]

Hello, check our new paper in BioRxiv. It describes new integrator module (INTS9/INTS11 and BRAT1) regulating the neurodevelopment program.

[bioRxiv @biorxivpreprint]

BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genes https://t.co/kkCIk3blz7 #bioRxiv

[GardiniLab @GardiniLab]

Join us for a FUSION Conference on "Genome Regulation through RNA" next February (11-14) in Cancun!
https://t.co/ndUnfkUoS5
The meeting will boast cutting-edge work on #epigenomics, #transcription, #lncRNAs & #smallRNAs biology, #genomeintegrity, #epitranscriptomics and more!
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[GardiniLab @GardiniLab]

What can machine learning do for your favorite protein complex? A lot! Especially if paired with proteomics and genomics. In collaboration with @WojtekGalej we characterized the 15th Integrator subunit! Shout out to @offley_sarah and @MorPfl for leading this effort #transcription

[Felipe Beckedorff @FBeckedorff]

Interestingly they show H3K4me3 is required to recruit integrator complex, which is essential for the eviction of paused RNAPII and transcriptional elongation.

[bioRxiv @biorxivpreprint]

Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity https://t.co/O3n0GI7YG7 #bioRxiv

[Shiekhattar Lab @ShiekhattarLab]

Our new paper is out on @ScienceAdvances The Integrator complex regulates microRNA abundance through RISC loading https://t.co/mVrayoU3yv
Well done @kirstein_nina and @SaDo47654137 and all collaborators.

[Nimer Lab @NimerLab]

Kicking off day 2 with Polycomb & noncoding RNA in cancer, at the 5th Biennial Miami Cancer and Epigenetics Symposium🧬 #MiamiEpigenetics2022 @SylvesterCancer @AsifaAkhtar1 @GardiniLab @harvardmed @ShiekhattarLab

[Chuan Chen, MD PhD @DrChuanChen]

#MiamiEpigenetics22 Great opportunities for learning and connecting. Many thanks to the organizers @SylvesterCancer and the world renowned speakers 👏👏 😊😊

[Sylvester Comprehensive Cancer Center @SylvesterCancer]

We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022

[Stephen D. Nimer, MD @DrSDNimer]

Thrilled that so many experts came to @SylvesterCancer symposium to discuss their most promising and recent research findings AND brainstorm to establish collaborations and help the trainees advance their science and career!

[Nimer Lab @NimerLab]

Impactful symposium in Miami this weekend! Some of our very own @ShiekhattarLab, @lluismorey, @thecimminolab and @TaylorJ_MD discussing the latest discoveries in cancer and epigenetics research. @SylvesterCancer #MiamiEpigenetics2022