Mark Shlomchik Lab

Autoimmunity, Lupus, Germinal Center B cells, Memory B cells, BCR signaling, Infectious Diseases

[Pitt Department of Immunology @pitt_immunology]

And check out the commentary by @RoserTP and @VinuesaLab: https://t.co/R5dXfWBKan

[Pitt Department of Immunology @pitt_immunology]

@ShlomchikLab and his team have solved a 20-year #lupus mystery! In a new @jclinicalinvest paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. https://t.co/IN1YaYfvSj

[Mark Shlomchik Lab @ShlomchikLab]

There is still much to learn! Is there a role for IL-12 in severe infection? Is there interplay with innate immunity? How is this response negatively regulated? How can it be shut off when it causes too much damage? Does IL-12 influence B cell memory?

[Mark Shlomchik Lab @ShlomchikLab]

Check out the N&V in @NatImmunol by Inaki Sanz about
@elsner_rebecca's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg.
https://t.co/ML4SH4yCzs

[Mark Shlomchik Lab @ShlomchikLab]

We are excited about new questions raised by these studies, discussed in Inaki Sanz’s N&V https://t.co/JCJplAmqQz. EF responses are prominent in autoimmune diseases including SLE, and infection-associated immunopathogenesis including COVID-19.

[Mark Shlomchik Lab @ShlomchikLab]

Congrats to lead author @elsner_rebecca, along with Shuchi Smita and @MShlomchik on their newest study, recently published in Nature Immunology!

[Nature Immunology @NatImmunol]

Shlomchik and colleagues find that IL-12 initiates a B cell-intrinsic feed-forward loop between IL-12 and IFNγ which promotes B cell proliferation and plasmablast differentiation. Read it here: https://t.co/vg3iltMbRR
https://t.co/3p11JjrJUI

[Mark Shlomchik Lab @ShlomchikLab]

We conclude that ABC are a diverse and dynamic population of B cells that promote autoimmune disease. Developing approaches to target ABCs specifically, rather than all B cells, could be beneficial in lupus. (12/12)

https://t.co/WAh8KdIVcL

[Journal of Experimental Medicine @JExpMed]

.@KMNickerson, @mshlomchik @Shlomchiklab @PittTweet & colleagues show that age-associated B cells are heterogeneous with respect to expression of memory and plasmablast markers. https://t.co/OInUxZvHRf
#Autoimmunity

[Mark Shlomchik Lab @ShlomchikLab]

In our latest @JExpMed study, we characterized age-associated B cells (ABCs) in a model of lupus. We found unexpected heterogeneity among ABC subpopulations, identified precursor-product relationships, and showed that reducing ABCs improved renal disease. A 🧵! (1/12)

[Mark Shlomchik Lab @ShlomchikLab]

Altogether this suggested that ABC undergo frequent cycles of reactivation, with some ABC progeny retaining the ABC phenotype but others terminally differentiating to PB. (11/12)