Gleb Sokolovskiy

[Martin Varsavsky @martinvars]

For the first time, a cancer medicine designed for one single patient has worked in a large phase three trial.

This week at ESMO, the big European oncology congress, Merck and Moderna presented INTerpath-001. They enrolled 1,137 people whose high-risk melanoma had already been removed by surgery. All of them got Keytruda, the standard immunotherapy, and two out of three also got intismeran, an mRNA shot built from their own tumor.

How do you make a medicine for one person? You sequence the tumor and a blood sample, software picks up to 34 mutations that only that cancer has, and those are written into an mRNA molecule that teaches the immune system what to hunt. A different drug for every patient, and they managed to manufacture it for more than 99% of the patients who were meant to receive it.

The result: after two years, 82.2% of patients on the combination were still free of cancer, versus 70% on Keytruda alone. The risk of recurrence or death fell 42%, and 58% once the six-month immunization was complete. Survival data are not mature yet, and this is only melanoma, but there are already three phase three trials in lung cancer.

The oncologist Georgina Long, principal investigator of the trial at Melanoma Institute Australia, put it well: "For decades, cancer treatment has largely been defined by where a tumor originates in the body."

That era is ending. Medicine is moving from treating the average patient to treating you.

[WarMonitor🇺🇦🇬🇧 @WarMonitor3]

BREAKING: Ukraine has carried out the world’s first medical evacuation of a human via a drone from the battlefield the 30th mechanised brigade of Ukraine managed to save their injured comrade from a minefield.

Just absolutely insane.

[Elliotte Friedman @FriedgeHNIC]

Sam Montembeault injured today at practice…should know more tomorrow about his situation/status

[Gleb Sokolovskiy @Shurshik14]

@ScottyHockey Happy Scotty Hockey!!!
I've witnessed a momentous moment too!

[Melanie @nycpix]

After an 8 hour bike ride w my clubs strapped to my back, squeezed in a round of golf before the storms toll in!

I kid I kid

This trip made possible by a motor vehicle

[Gleb Sokolovskiy @Shurshik14]

@vtchakarova They were the only option to NOT vote for the UR

[Elliotte Friedman @FriedgeHNIC]

https://t.co/WQNf9gV3ht

[Jonny Lazarus @JLazzy23]

Matt Coronato will score 40 goals

[Scotty Hockey @ScottyHockey]

At least he's still in the Metro to exploit.

[Gleb Sokolovskiy @Shurshik14]

@HLundqvist 😭

[Gleb Sokolovskiy @Shurshik14]

@aelfred_D 🤣🤣🤣🤣

[Suneel Dhand MD @DrSuneelDhand]

Never leave your loved one alone in the hospital. Every hour you are allowed to be there, if you are able to, I highly recommend being there.

Be perfectly cordial with staff. But watch over everything like a hawk.

Trust me on this.

[Gleb Sokolovskiy @Shurshik14]

The financial strain of ongoing treatments and travel is overwhelming. Every donation, no matter the size, can make a real difference. Please consider supporting our cause or sharing this message. Thank you for your kindness. https://t.co/YievOtjiDY

[Gleb Sokolovskiy @Shurshik14]

@ThaddeusLux @central_paladin @JoelWebbon 🤣

[Gleb Sokolovskiy @Shurshik14]

@xai It's in some other language

[Gleb Sokolovskiy @Shurshik14]

@pattyoc1 🤣

[Blueshirts Nation 🗽 Rangers Fan Club @NYRangerFanclub]

🚨WINTER CLASSIC GIVEAWAY!🚨

If Trocheck scores vs Florida we will GIVEAWAY this Rangers Hat! #nyr               

🟥RETWEET
⬜️FOLLOW
🟦LETS GO RANGERS

https://t.co/2i0sHRnMtY

[Gleb Sokolovskiy @Shurshik14]

@GadSaad @SenSchumer If he continues...
Immediately...

[John Ziegler @Zigmanfreud]

Effectively, as of right now, the GOP sold its soul & long-term credibility for a cult leader who allowed them to defeat 2 awful POTUS opponents (losing to a 3rd) and name 3 okay SCOTUS judges…

In response, the barbarians are now at the gate, & Trump left the key in the lock.🤮

[Gleb Sokolovskiy @Shurshik14]

@nypostsports @NYP_Brooksie Get well soon, sir.