Simeng Lin

Gastro Specialist Trainee | IBD researcher

[Eric Topol @EricTopol]

Not every day you see an odds ratio of 50 (for interleukin-10 autoantibodies and a common HLA allele).
~80% of patients with inflammatory bowel disease (IBD) have this HLA allele
These individuals (~3.5% of IBD) may benefit from B cell depletion (such as achieved via CAR T).
https://t.co/ax0zSPSfhK
https://t.co/qIdoO5uLSR

[RAPIDIBD @PANTSresearch]

PANTS - Maximising patient data and samples + fantastic collaboration

Recruitment March 2013- July 2016

PANTS - FACTS
👥 1600+ patients
🩺13900 patient visits
🏥118 NHS Hospitals
👩‍💻300 NHS research staff
🧪~90000 frozen samples
💩~6000 poo samples
@tariqahmadIBD

[Simeng Lin @SimengLin]

@Josiaharvey @katielunnon @EPishva @NE_Clifton Congratulations Josh!

[Emma Wesley @dremmaw]

Due to some last minute changes with HEE posts we are advertising for a trust registrar. Recent post holders have been OGD trained within 9 months and have had lots of abstracts accepted. Also change to work on the exciting liver project @PHI_Comms
@BSGTrainees

[Simeng Lin @SimengLin]

@DrNickKennedy sharing data on the 3-year anti-TNF outcomes from the PANTS study (awarded Best Clinical Science abstract)

On behalf of @nchanchlani1 @exeteribdresea1 and with thanks to all the PANTS collaborators and patients.

[BSG @BritSocGastro]

We are delighted to congratulate Dr Neil Chanchlani on winning the BMJ Open #Gastroenterology best clinical science abstract for oral presentation with Dr Nick Kennedy presenting on his behalf at the #BSGLIVE23 🎉 @BMJ_Open

[Simeng Lin @SimengLin]

This is indeed a great achievement from @esaunsbury @dan_maggs , from a local audit, to a South West trainee network project @SPRinG__network , to a BSG endorsed national audit @EVOLVE_EOLC @ibdseb !

#BSGLIVE23

[SPRinG network @SPRinG__network]

Fantastic to see how the EVOLVE national audit has developed from the initial regional project we supported in 2021/2022. A great example of what can be achieved by trainee-led initiatives.

@EVOLVE_EOLC #BSGLIVE23

[Ben Hudson @hudsonbe81]

Calling all budding hepatologists!

Exciting PhD opportunity with the Exeter liver team

✅Fully funded for 3 years
✅Opportunity to continue some clinical work (inc HPB endoscopy) if desired
✅Live in beautiful Devon

Please RT!

DM for more details

https://t.co/ctUxbzepVi

[Simeng Lin @SimengLin]

@sheiybani Congratulations Gio! Great achievement with everything else you have going on!

[Simeng Lin @SimengLin]

@gw4_cat @PsyEpigenetics @uniofexeHLS @UofE_Research @wellcome Thank you @gw4_cat for the support, right from the start to finish (hopefully soon!)

[Jonathan Mill @PsyEpigenetics]

New preprint by @SimengLin identifying DNA methylation predictors of anti-TNF treatment in IBD patients. https://t.co/Taku2hNdUl @uniofexeHLS @gw4_cat @UofE_Research

[Simeng Lin @SimengLin]

@PsyEpigenetics @eilis_hannon @tariqahmadIBD @JamesGoodhand1 @DrNickKennedy @nchanchlani1 @ClaireBewshea @exeteribdresea1 @BenYHBai

[Simeng Lin @SimengLin]

Pleased to share our preprint highlighting the DNA methylation changes in anti-TNF treated patients from the @PANTSresearch study.

Link to preprint: https://t.co/XEXASF4vV8

Thanks to all our patients, collaborators and funders.

[Simeng Lin @SimengLin]

This work has also been presented at #ECCO23 DOP88, a recording of which can be found on the ECCO'23 Virtual Platform.
https://t.co/NY0AD9d2Zv

[Aamir Saifuddin @aamirs28]

Excited to share our joint @ResearchBsg / @NIHRresearch Introduction to Research event for all #Gastro trainees 🕵🏼🧑🏾‍🔬🧑🏻‍⚕️🧑🏿‍💻! 21/4/23 in York. Programme below! Huge variety of speakers/topics + invaluable advice. 8️⃣ weeks to go! Sign up early, limited spaces! https://t.co/QgkX1su4j3

[Wilsons Restaurant @JanWilsons]

So we’ve had a string of cancellations for this Saturday night. Literally lost half the restaurant. If anyone wants to eat at Wilson’s this Saturday do get in touch. We have space!
RT

[Jonathan Mill @PsyEpigenetics]

Christmas cruise on the River Exe….great afternoon with the ⁦@UniofExeter⁩ genetics and epigenetics groups.

[Nick Kennedy @DrNickKennedy]

Exeter IBD research group having a long overdue night out at @topshambrewery on Exeter Quay

[Simeng Lin @SimengLin]

Risk of immunogenicity and rates of drug persistence to second anti-TNF following immunogenicity/treatment failure to first anti-TNF.

Results summarised here:
@nchanchlani1 @exeteribdresea1

[Simeng Lin @SimengLin]

Great project led by @esaunsbury and Dan Maggs!

[EVOLVE @EVOLVE_EOLC]

We’re delighted to launch our trainee-led national audit, focusing on end of life care in patients with advanced chronic liver disease. Keen to get involved? See the below details to sign up! Thanks to @BritSocGastro, @NIHRresearch and @uk_torch for their support #LiverTwitter

[Simeng Lin @SimengLin]

Results from the latest @clarityibd paper published in @Gut_BMJ summarised here: