Simon Pybus

[Jesus Rodriguez Baño @jesusrbano]

ASTARTÉ is out in @TheLancet

Free access for 50 days at https://t.co/NBm4zzJWwW

@HUVMacarena @ibis_sevilla @CIBER_ISCIII @UniversidadSevi @Medicina_US @FISEVI_sevilla @Fra_CogliatiD92 @VirginiaPalom10 @zairita_wow

See the thread 👇

[ESCMID @ESCMID]

🦴🦠 This online course focuses on implant-associated infections, with special emphasis on prosthetic joint and fracture-related infections from infectious diseases, microbiology, and orthopaedic perspectives.

💡 Learn more and sign up today:
https://t.co/McNnoHo9VD

[Simon Pybus @SimonPybus]

@allisonoconn Today I learned (genuinely- coincidence) that when you treat Coxiella IE, the purpose of hydroxychloroquine is to increase intracellular pH which apparently improves intracellular kill from doxycycline.

[Aurélien Dinh @aurdinh]

RODEO is out! 🚀 First presentation at the French National Congress @ABsteward @DrToddLee @BradSpellberg @davidantibiotic @Josh_S_Davis

[NEJM @NEJM]

In the SNAP trial, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality in patients with methicillin-susceptible Staphylococcus aureus bacteremia and had fewer nephrotoxic effects. Read the full trial results and Research Summary: https://t.co/5Z39siPUhS

[Simon Pybus @SimonPybus]

@BradSpellberg @JulienPrvost5 @DiorIzzy @ABsteward @MRodgersRodgM What duration are you using for prostatitis? Seen observational study of 6w but presumably 2 weeks would be enough

[Todd C. Lee @DrToddLee]

Today in @NEJM we show that cefazolin should be the preferred agent for MSSA bacteremia

https://t.co/BCVDzDfUqL

We also show in @TheLancet that penicillin should be preferred to anti-staphyloccal penicilins for PSSA

https://t.co/X3JSm7NxJG

@snap_trial @RIMUHC1

[Emily McDonald @DrEmilyMcD]

Will you start using an up front vanco taper for cdiff?

99% probable it is superior to prevent early recurrences versus 14d. Not bad to delay recurrences in sick frail people.

I have changed my practice.

Now we will run an RCT of vanco P-T vs fidaxo

[UK Health Security Agency @UKHSA]

We know the threats of viruses and bacteria, but what about fungi? 🍄🔍

Fungi can be part of our normal flora, but one stands out for its resilience. Our blog post explains why we are keeping a close watch on Candidozyma auris in particular.

�� https://t.co/bd9F7otnRu

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Super interesting!
🆕⚡Can chlorhexidine bathing reduce Candidozyma auris shedding? #IDXposts https://t.co/oekDKLsvo0

[RC of Pathologists @RCPath]

The College has responded to the Scottish Government’s consultation on the planned merger of NHS Education and NHS National Services in Scotland from April 2026. Our response highlights the key priorities that must be enabled to ensure success.

https://t.co/Ut7KFe9B9f

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

👉 Evidence is limited, but reducing β-lactam doses too early in AKI may underdose critically ill patients at the worst possible time.
🛡️ Delayed dose reduction (after reassessing kidney recovery ~48H) might improve mortality—but better prospective studies are urgently needed.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕🔥🦴 Our 2025 Update to @WikiGuidelines for the Management of Pyogenic Osteomyelitis in Adults 🌟 @BradSpellberg
🧪 Diagnosis
🔹 Nuclear scans & paravertebral biopsies → high accuracy
🔹 Bone histopathology > culture
🔹 MRSA nares negative → >90% NPV for DFO
🔹 PEDD > CT-guided biopsy for spinal osteomyelitis
⚠️ ESR, procalcitonin, CRP → poor reliability
💊 Treatment
✅ Combined medical + surgical care improves outcomes
✅ Oral ≈ IV therapy; IV lead-in optional (POvIV 10th RCT confirms)
✅ Cephradine, cephalexin, cefadroxil, doxycycline, tedizolid → oral options
🧬 Rifampin adjunct → may reduce PJI/vertebral osteomyelitis failure
⚠️ Long-acting lipoglycopeptides → limited data, high cost
🔪 Surgery
⚖️ One- vs two-stage prosthetic exchange → similar outcomes
🩻 MRI pre-amputation (DFI) → lower re-amputation risk (16% vs 32%)
📌 Residual osteomyelitis on histopathology → poor predictor
💡 Takeaway: Oral therapy works; combine medical & surgical care; tailor surgery with imaging.
🔗 Full WikiGuideline: [link]
https://t.co/3RChKI8Jkm

[NHS Golden Jubilee @JubileeHospital]

As part of Prevention and Control of Infection week, our #TeamJubilee team were out highlighting the importance of infection prevention and control.

From hand hygiene to safe care practices, every small action helps protect our patients, visitors and colleagues.

[ESCMID @ESCMID]

⏰In 2 weeks: ESCMID/ISAC joint webinar on how hospital design directly impacts infection control

Speakers: Margreet Vos & Paul Anantharajah Tambyah
Moderators: Souha Kanj & Robert Skov

📌13 August 2025 @ 12PM CEST
Register today & join us! https://t.co/iVGADRriiW

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💫Standing on the Shoulders of Imperfect Humans: Adjunctive Therapy for Enterococcus faecalis Infective Endocarditis
The authors travel back in time and provide a nuanced critique of the limited seminal evidence underpinning adjunctive therapy for EFIE
https://t.co/4LtEYOTqrO

[Healthcare Infection Society @HIS_infection]

Join us and Architects for Health at this FREE lunchtime webinar next week to explore how the move towards water-free care in healthcare settings is shaping the future of hospital design .

Speakers:
@manjulameda, Dr Joost Hopman, Cheryl Callow

Register https://t.co/YIP7lhAlyZ

[Paul Sax @PaulSaxMD]

The SNAP trial may finally resolve some of the longest-running debates in SAB management (cefazolin vs semi-synthetic PCN? Is PCN really active vs PSSA?).
Congrats to @syctong @Josh_S_Davis, and the global team who made this ambitious trial happen. https://t.co/n8ZXrqrRM6

[Francesco Cogliati Dezza @Fra_CogliatiD92]

@ESCMID day 2!
💥Temocillin not inferior to meropenem
📢New alternative for ESBL+ is coming?
🦠Presented data on RCT ASTARTÉ at #ESCMIDGlobal working on final analysis
@jesusrbano @syctong @HUVMacarena @SaludISCIII

[British Journal of Anaesthesia @BJAJournals]

Antimicrobial prophylaxis for surgical site infections (SSI) may require dose adjustments in #obesity. Cefazolin #SSI prophylaxis 2g with redosing at 4hr is effective in obese and non-obese patients https://t.co/SMJoBB0BQS