These numbers are shocking. It's like we got a new frontier AI model but for the body.
Lilly's phase 3 results for retatrutide:
> highest dose lost 28.3% of body weight in 80 wks
> 70 lbs ave
> 45% lost 30% or more of their body weight
> 65% on the top dose no longer clinically obese
Retatrutide is more dynamic than semaglutide and tirzepatide because it targets three receptors (GIP, GLP-1, and glucagon), versus one and two, respectively.
Side effects, on the highest dose (12mg), were higher for retatrutide than tirzepatide (nausea and GI), with an 11.3% drop out rate. The lowest 4mg dose still delivered 19% loss with fewer dropouts than placebo.
We just wrapped what began as an 8-hour challenge - and it ran for 200 hours without a failure
Shoutout to the team for the hardcore engineering behind F.03 and the robust Helix models powering it
Imagine if you were forced to spend 8+ hours a day with one person from age 15 to 85.
More than your parents, spouse, or kids…combined.
Now imagine the person is a moron, boring, doesn’t challenge you, and you hate them. Sounds terrible right?
On the other hand, imagine the person is fascinating, forces you to grow, and you love them. Sounds great right?
That person is your work.
Worth treating it like the most important person you’ll spend your life with, not what show you’re gonna watch on Netflix tonight.
I started the @elonmusk biography by @WalterIsaacson on the 2nd, finished it on the 8th. After some rumination, I believe the hardcore sense of urgency he uses is the only way to operate. So much learned that I’ve already implemented into my companies. do you agree?
PSA:
The amount of income streams you have doesn’t make you more or less wealthy.
It makes you more or less distracted.
Jeff Bezos didn’t have seven side hustles.
He built one Amazon.