SlavoffLab

We are a young Chemical Biology/RNA/Molecular Genetics lab at Yale Chemistry, working toward discovering the dark matter of the human genome.

[Yale Chemistry @YaleChem]

Seven Chemistry students were awarded #NSF fellowships for their graduate research, showing great promise for future advancements in chemistry. We’ve spotlighted them and their research in this article. Meet the Yale Chemistry NSF Fellows! https://t.co/bruMQnL2cg

[SheqLab @ShechnerLab]

Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

https://t.co/gVMCVbSRoS

[Lena Ho @Holab_DukeNUS]

Ever wondered why we need respiratory supercomplexes?
New findings from our lab, in collaboration with @LettsScience, show how a specialized supercomplex - the SC-XL - can help mitochondria overcome some respiratory defects & provide cardioprotective benefits.
Studying #Microproteins (i.e. Brawnin) led to this amazing discovery, a testament to the power of small!
https://t.co/FVnqZYq2PV

[SlavoffLab @SlavoffL]

@Slavofflab will continue our track record of sporadic-at-best social media engagement at🦋🌈. See you ... occasionally!

[SlavoffLab @SlavoffL]

@ShechnerLab @naturemethods Love to see this out!! Amazing work!

[SheqLab @ShechnerLab]

Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!)

O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵
https://t.co/gBGsQ6dBs9

[Michael Bollong @MichaelBollong]

Check out our News&Views highlighting the work of @Keribackus in @nchembio : a new form of cellular stress and collateral degradation of proteins induced by electrophilic small molecule fragments.

Work of @RosaCarolinae + @KaylaENutsch

https://t.co/u5AyMNbiUu

[Keriann Backus @Keribackus]

Thrilled to share our new study in @nchembio describing the proteome-wide impacts of electrophile stress in the context of covalent fragments. Big congratulations to first authors Ashley Julio @AshleyJulio4 and Flowreen Shikwana @FShikwana ! 1/5 https://t.co/4bBtk5jI3J

[Yale West Campus @YaleWestCampus]

Led by the Yale Nanobiology Institute's Julien Berro, a team of scientists have received an #NIHHighRisk award to build a new sensor to target the mechanical properties of diseased cells https://t.co/VdnCDZqcfj @NIH_CommonFund

[nature @Nature]

Not for the first time, all Nobel Prizes in scientific disciplines this year have been awarded to men

[Wenkel Lab @microProteins]

Please RT: We have TWO postdoctoral positions available to study microProtein function in tomato. If you’re interested in working in an international team in a strong plant research center in a literally cool location. Please apply here: https://t.co/yCjynKfrjQ

[Jen Heemstra @jenheemstra]

My first op-ed is out!

Starting my faculty career was challenging in many ways, and one of those is that I had a leadership job that I didn't expect and wasn't (really) prepared for.

Thanks to @insidehighered for the chance to write about this and share some advice!

[Wenkel Lab @microProteins]

Dear small protein/microprotein/sORF enthusiasts. I am currently editing the first methods book on microproteins. If you would like to contribute a chapter please get in touch! I would also appreciate if you could share this information in your network.

[Yale Chemistry @YaleChem]

We’re hiring a tenure-track professor (any level) to teach courses and develop research programs in experimental physical, theoretical, or organic chemistry, starting 8/1/25. Apply by 9/30/24 to be considered for the first round of interviews. https://t.co/wmYOZ2qNrI

[SlavoffLab @SlavoffL]

@brian_b_liau @liaulab Amaze!

[Keriann Backus @Keribackus]

Our lab’s first @chemcomm! We find that amidine-capped cysteine residues can be cleaved by trypsin to improve detection of tough-to-ID cys (e.g. resis found in very long sequences lacking K/R). Congrats to first author @SamioOfori and team! https://t.co/EmdBKSudVz

[Jen Heemstra @jenheemstra]

If you have a leadership job, then you also have a kindness job.

Yes, there is work to get done and goals to meet. But we also have a responsibility to leverage our authority and decision making capability to uphold human dignity.

[SlavoffLab @SlavoffL]

@BC_UCLA @Keribackus Zero surprise, many congrats!

[Brian Liau @brian_b_liau]

How do intrinsically disordered regions (IDRs) regulate protein function? Today in @MolecularCell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6)
https://t.co/XRNw9Q4V7U

[bryan dickinson @chembioBryan]

Do you:
A) Love chemical biology?
B) Live in Europe or want to visit Germany?

If you answered yes to either, why are you not yet already signed up for this year's EMBO Chemical Biology workshop, taking place Sept 9-12 in Heidelberg?

https://t.co/zjWXJaT4Gf