Catching up on reading this Sunday? Check out the Lou Lab's latest papers focused on minor collagens in tendon development and healing for some interesting and surprising stories!
Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development: https://t.co/jJOnePnEKG
Attention glycosaminoglycan afficionados! Be sure to check out @BlankJonathon's latest paper on GAG depletion in the Achilles Tendon! https://t.co/loudeoCmQt
Register now for an @ors_tendon #WebinarWednesday on Sept 24, 12 PM CST, A Tendon-cy to Heal: Regenerating Tendons & Ligaments in Zebrafish. Hear from Thomas Schilling, Jenna Galloway & Joanna Smeeton on the latest #tendon & ligament regeneration. 🔗https://t.co/lsF6fDR6FG
🦴 Does lactation strengthen or weaken the skeleton? Check out this
@ORSsociety Basic Science Tip to learn how elevated PTHrP shrinks both bone & marrow fat, while PTH1R signalling worsens bone loss, revealing new hormonal control of maternal bone health.
https://t.co/zhuC0Y6n3V
Microsoft support for Windows 10 Pro ends on October 14, 2025. Is your lab prepared for the transition to Windows 11? Our latest blog post discusses how and why to migrate your testing systems: https://t.co/fj3h0zQIPD
Looking for a fun Monday night activity to fill the Love Island-sized hole in your heart? Check out the Lou Lab's latest paper on age-related changes in the supraspinatus tendon: https://t.co/9W2b5YTdQ9
#(Rotator)CuffingSeason
You (bigly)can't miss the chance to be (decor)in the know about all things SLRPs and tendon healing! Check out this paper from Christelle and the Lou Lab team!
A serious injury to aging tendons often means a slower, less complete recovery – one that science is still trying to fully understand.
Researchers used a preclinical model of aging to investigate how two key proteins, decorin and biglycan, influence tendon healing. Using a controlled knockdown approach, they assessed structural, genetic, and mechanical outcomes across early and late healing stages. They found:
🔹 When removed early, decorin knockdown appeared to improve recovery of viscoelastic properties.
🔹 Biglycan deficiency delayed initial healing but didn’t impair final mechanical strength.
🔹 Collagen fibril architecture changed, yet quasi-static strength measures were unaffected.
These findings suggest subtle, protein-level interventions may help aged tendons heal smarter, not just stronger.
𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: https://t.co/92fy1DE4Lb
𝗦𝘁𝘂𝗱𝘆: Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May Not
𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Christelle Darrieutort-Laffite, Stephanie N. Weiss, Courtney A. Nuss, Joseph B. Newton, Jeremy D. Eekhoff, and Louis J. Soslowsky
@Penn@PennMedicine@McKayLaboratory@PennEngineers@pennbioeng@SoslowskyLab@CHUnantes@Inserm
𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: https://t.co/Gyz8DNneUg
Jon (@blankjonathon) represented the Lou Lab at @PennOrtho Research Day, discussing efforts to generate overuse tendinopathy models through the @upenn_pat_cort!
The @SoslowskyLab are at it again, showing that 16 weeks high-speed running does not induce #Achilles#tendinopathy in rats. Do rats have better post-exercise recovery than humans. Can we learn anything from that to improve human tendon recovery? https://t.co/xTqPbs8FYQ
The Real Collagens of Tendon Healing (also known as @Maggie_Tamburro's defense) is coming to a big screen near you!
Thursday, 5/15, at 10:00 AM EST; DM for Zoom info!