Our latest on 🫀 health, 🧬, & 🤰 now out in @JACCJournals#JACC
⬆️ 1st-trimester CV health strongly associates w/ ⬇️ risk of hypertensive disorders of 🤰 (HDP)
overall & across levels of HDP 🧬 risk
➡️ opp to prevent 🤰 complications & long-term CVD
https://t.co/F8aUFXWRN0
Dr. @jodieingles27, et al report 29 genes with definitive, strong, or moderate evidence of causation for #HCM or isolated LV hypertrophy, including sarcomere, sarcomere-associated, and syndromic conditions 👉 https://t.co/Zr0AuqM80p
#JACC#cvHCM#CVD#ClinGen#cvGenetics
New paper in @Circ_Gen: Traditional models assume genetic risk is constant, but @pnatarajanmd & team including @tigerstatdoc show CAD risk is dynamic. Genomic & clinical factors interact differently across life stages. @cgm_mgh@mghcvrc@mghcvfellows https://t.co/98JLgQDWXm
Delighted to share our study by @tigerstatdoc with @aklfahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events https://t.co/oLRpkE3cNW @Circ_Gen
We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes," now published in JAMA Cardiology, led by the brilliant undergrad @akshayaravi22! 🎉
https://t.co/w7eF5dmrLt
Our study led by @kparuchuri@MGHHeartHealth using an EPIC-integrated clinician dashboard 💻 + smartphone app📱 onboarded upon HF hospitalization discharge 🏥 to improve HF management out in @JCardFail.
So proud of our versatile team @MGH_RI continually forging into new areas
About 1 in 500 people in the U.S. are living with HCM. It’s the most common inherited heart disease & many people are unaware. AHA has launched an initiative to improve systems of care. https://t.co/otMAbYTSLR
#hcm#aha100#cardiotwitter
The GLGC is a global collaboration of 100s of scientists interested in lipid genetics. Check out our recent review, where we highlight 🔑 contributions from the GLGC across the last 15 years.
#GWAS#Genetics#Lipids#PRS
👇
Check out this International Consensus statement on platelet function and genetic testing in #PCI published in this issue of #JACCINT https://t.co/pnBY6dIFJg
#P2Y12i#PrecisionMedicine#cvGenetics
🧬 This Genetic Counsellor Awareness Day, we celebrate and acknowledge the dedication and compassion of genetic counsellors across Australasia. Thank you for your invaluable support! #ThankYouGCs#GCAwarenessDay#ANZGeneticCounsellors
Forthcoming guidance will recommend labs report VUS subclasses. We share experience of 4 labs including rates of reclassification of VUS subclasses. By highlighting VUS-high and downplaying VUS-low, this will be game-changing for dx genetic testing. https://t.co/u0tq3vVS6B
🚨JOB ALERT🚨
I'm looking for an #ImplementationScience research fellow to join my team @Sydney_Uni. You'll work on various projects and partner with the @SHPartners Implementation Science Academy
https://t.co/lMYOnk8NJ5
Gestational 🤰 diabetes is associated w/ long-term 🫀 disease risk, but is GDM *causal* for CVD?
A new analysis using 🧬 suggests the answer is no - rather, GDM & CVD likely share upstream risk pathways.
Our editoral led by @DrMArdissino in @ehj_ed#EHJ: https://t.co/ViaMPJWe53
Why should I get a #genetic testing for my #HCM patient? Well, the question should be "why not?" Great talk by @tikuowens
It is useful for family screening, #phenocopies identification, potentially choose appropriate treatment and even as a prognostic tool #HCMSummit8
We then observed that the penetrance of this variant is influenced by the T2D PRS. Carriers of the variant + highest tertile of the PRS had similar odds ratio (OR~18) as carriers of confirmed pathogenic variants while carriers with low PRS showed OR ~2.6