Brian, for the love of god, you cannot take a health database, click 'sort' and think that the top 5 drugs patients who survive longer happen to be taking are causal to the benefit those patients received. 500k is actually not a large cohort for a database, needs alpha correction, was very unlikely to be prespecified, etc. that's why no one is impressed with these studies and they're published in trash journals.
this study showed a slight increase in CV events with PDEs vs placebo
https://t.co/y3AbyTFHUU
the mechanistic rationale is not there and your explanation is terrible. ALL PDEs metabolize cAMP/cGMP, thats why they are phosphodiesterases. are you suggesting we should inhibit all PDEs?!
by the same logic we should all be taking ERAs too. why not ARBs and ACEs? screw it i'll take inhaled treprostinil too. might extend my life. then i'll run SQL queries on health databases until i see a 'signal', bonferroni may roll in his grave but i will be vasodilated.
PROMETHEUS BOUND by Aeschylus and PROMETHEUS UNBOUND by Shelley are the world’s two most important books. They are the true Old and New Testaments, which put the Bible to shame. Jesus is a pitiful ape of the original Christ and crucified Creator of humanity.
Pu-Yi was a huge piece of shit in his personal life, he sold (one of) his wives to sex slavery circus freaks where people would throw peanuts at her and order her to dance like a monkey and the. watch her get raped by animals.
He was gay/bisexual and beat several of his teenage rent boys, to death.
@JohnsonKel47943@SauceTray@GabeEcon I'm biased here since I live in NYS where the minimum wage is relatively high. The point still stands that most minimum wages are below the price of labor, but I thought it worthwhile to point out that this isn't true universally in the US.
@asidjHijklmno@PureThe0ry That's what I meant, that despite MMTers often being progressives arguing for graduated taxation, if their theory were true the benefits of taxing the rich more highly would be much lower, and a much simplified tax code would be needed to change taxes more often