Daniel E. Weeks

Statistical geneticist. Professor of Human Genetics and Biostatistics at the University of Pittsburgh. Assiduously meticulous. Mastodon: @StatGenDan@fediscience

[Charleston Chiang @CharlestonCWKC]

Please RT!

[Jenna C. Carlson @jenccarlson]

🧬Postdoc Opportunity in Statistical/Computational Genetics!🧬
Join our team in Human Genetics @PittPubHealth! Focus: Genetic etiology of cardiometabolic disease in Samoans & Pacific Islanders. Collaboration with @CharlestonCWKC
https://t.co/GH1Bpgb8qG
#Postdoc #Academicjobs

[Lacey W. Heinsberg @lwheinsberg]

Feeling frustrated when trying to put together your dbGaP data submission? @StatGenDan and I are excited to announce our new R package, #dbGaPCheckup, which we designed to help YOU with this complex process! 🧵(1/n) #Rstats #Genetics #dbGaP #DataQC #DataSharing #OpenScience

[Daniel E. Weeks @StatGenDan]

@michelnivard Challenging to do (even somewhat) effectively without amplifying. This guide may have some good ideas: https://t.co/Q1xktVHP47

[Daniel E. Weeks @StatGenDan]

@OcOutlier I hope it all goes smoothly, proves very helpful, and that your recovery is smooth and swift.

[Christoph Thaiss @ChristophThaiss]

We are excited to share our new work @Nature, led by @Lenka_Dohnal, uncovering a gut-brain pathway that regulates the motivation for #exercise. (1/7)

https://t.co/0FWIHfCw17

[Daniel E. Weeks @StatGenDan]

@emollick The made-up incorrect “facts” & frequent wrong definitions in the midst of convincing sounding text markedly reduces the value of ChatGPT output & creates the need for extensive and accurate fact-checking. Always wondering which parts of its output are wrong. It is often wrong.

[Harald Ringbauer @HaraldRingbauer]

We released a commentary on Ioannidis et al (2021) as a preprint. To date the settling of Polynesian islands, they inferred split times using IBD segments shared between modern genomes. We show that their estimator is biased to be ca. 300 years too old. https://t.co/US8cJ43Dey

[Daniel E. Weeks @StatGenDan]

@SundermannAJ I see two accounts for you on Mastodon. The second is @[email protected] ?

[Daniel E. Weeks @StatGenDan]

Bravo "Annals of the Rheumatic Diseases" for giving the option to download a combined PDF containing both the manuscript and the Supplemental Material! This is a time saver, as I almost always end up needing to read something in the Supplemental Material.

[Daniel E. Weeks @StatGenDan]

"it’s also wise to simply not use filenames that contain spaces or other strange characters. Simple alphanumeric names with either dashes or underscores are best." @vsbuffalo in his book "Bioinformatics Data Skills".

[Daniel E. Weeks @StatGenDan]

@doctorveera Wonderful thread! However, the MAF is not 0.025 (The map fig legend is confusing). All of the MAF estimates were <0.025 with wide confidence intervals, and in our largest sample, from Samoa, the MAF was 1.25% [95% CI 0.88%- 1.75%]. Fig here based on Table 2. Need more data.

[Daniel E. Weeks @StatGenDan]

@TonyMerriman2 Nice thread! However, not sure the allele frequency is ~2% as all but one of the minor allele frequency estimates were smaller with wide confidence intervals, and in our largest sample, from Samoa, the MAF was 1.25% [95% CI 0.88%- 1.75%]. Fig based on Table 2. Need more data.

[Daniel E. Weeks @StatGenDan]

'if standardized coefficients do not add information, they certainly do not add meaning. "To replace the unmeasurable by the unmeaningful is not progress" (Achen, 1977, p. 806).' - King G. American Journal of Political Science. 1986 Aug;30(3):666–687.

[Daniel E. Weeks @StatGenDan]

I have set up a Mastodon account at @[email protected], and used https://t.co/GxJvNno8JJ to easily populate my follows list. As that works by searching your Twitter profile for your Mastodon ID, please add your Mastodon ID to your profile so I can find you on Mastodon.

[Daniel E. Weeks @StatGenDan]

This guide to Mastodon is great.

[Oscar Baruffa | Now on Bluesky @OscarBaruffa]

Also trying out the #RStats semi-gration to mosstodon, I'm
@[email protected].
This guide by @djnavarro helped me https://t.co/xlAhuF0rag

[Daniel E. Weeks @StatGenDan]

Rule 3 revised: If possible, cut words.

[Adam Kucharski @adamjkucharski]

Learn Orwell’s rules of writing (although you may need to apply rule 6 to rule 5 occasionally): https://t.co/4mSXlVVxMD

[Daniel E. Weeks @StatGenDan]

Sounds good to me. My call sign is KB3WIO.

[Daniel E. Weeks @StatGenDan]

@ProfJohnATodd @jcbarret My first genome-wide linkage study in 1988 used 171 RFLP markers!
I don’t show up as an author - PubMed couldn’t handle long authorship lists: RA Gatti, I Berkel, E Boder, G Braedt, P Charmley, P Concannon, F Ersoy, T Foroud, NG Jaspers, K Lange, et al
https://t.co/4o7694HXhx

[Daniel E. Weeks @StatGenDan]

@IanJMackay Yes, please do!

[Daniel E. Weeks @StatGenDan]

“Mathematics may be compared to a mill of exquisite workmanship which grinds you stuff of any degree of fineness, but nevertheless what you get out depends on what you put in - … so pages of formulae will not get a definite result out of loose data.”
TH Huxley