Steensma Lab

Laboratory of Musculoskeletal Oncology at @VAInstitute studying NF1 tumor progression, sarcomas, breast cancer, and translational therapies. #EndNF

[Steensma Lab @SteensmaLab]

Congratulations to our newest graduate, Dr. Rae House! 🎓All the best for your postdoctoral research with the Lien Lab @eclien

[Van Andel Institute (VAI) @VAInstitute]

Congratulations to Alix Booms, Ph.D; Shelby Compton, Ph.D; and Rae House, Ph.D, who recently received their Ph.D. in molecular and cellular biology from Van Andel Institute Graduate School!

[Steensma Lab @SteensmaLab]

To learn more about the role of Nf1 in pretumorigenic mammary stromal cells, check out our newest publication in @FrontCellDevBio 🐁

https://t.co/Ba5XbINAJ2

Congrats to first author @amenusha , @VAInstitute cores, & collaborators that contributed to this study 💐 #EndNF

[Menusha Arumugam @amenusha]

🎉 Excited to share part of my PhD work with @SteensmaLab is now published in @FrontCellDevBio 🧬

We showed that germline Nf1 mutation in rats disrupts mammary adipocyte differentiation & increases collagen deposition prior to breast cancer formation 🐁

https://t.co/8IChztDBCy

[Scott Rothbart @RothbartLab]

Registration closes May 10 for the VAI Epigenomics Workshop. This 3-day, hands-on, problem-based experience will immerse PhD students in the latest epigenomics research and techniques. Please share with anyone who might be interested! https://t.co/OgvPnnbaOc

[Steensma Lab @SteensmaLab]

A new doctor in the house 🎉 Congratulations to Dr. House for successfully defending her dissertation today🥂

[Steensma Lab @SteensmaLab]

Congratulations to first author @jamie_grit , @sydney51605 + other coauthors, and collaborators! 💐

#EndNF

[Steensma Lab @SteensmaLab]

Excited to share our newest publication in @oncogenejournal 🎉

“p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs”

Highlights below 🧵

Read full paper here:
https://t.co/JMlYqZi3Aw

[Steensma Lab @SteensmaLab]

p53 loss drives a selective clonal advantage in MPNST by promoting acquired resistance to targeted kinase inhibition and modulating lineage plasticity pathways.

[JamieGrit @jamie_grit]

@SteensmaLab https://t.co/qje8hREf3a

Read the full article for free here!

[Steensma Lab @SteensmaLab]

Congratulations to first author @jamie_grit and coauthors! 🎉

Read more here: https://t.co/r2Jfdj03sr

[Steensma Lab @SteensmaLab]

In our latest publication in @theJIDJournal, we developed a patient-derived explant model for cutaneous neurofibromas that can be leveraged for mechanistic studies and preclinical drug testing.

[Steensma Lab @SteensmaLab]

As proof of principle, we employed our novel explant model to extend our prior findings regarding differences between downstream RAS-mediated inflammation in CNFs. We found that ex vivo glucocorticoid treatment was able reduced inflammation in these explants.

[Steensma Lab @SteensmaLab]

Congratulations to graduate student, Rae House, on her first first author publication! 🎉

Thank you to our funding sources, coauthors, collaborators, and @VAInstitute cores for all their contributions to this project.

[Steensma Lab @SteensmaLab]

Excited to share a new publication from our lab - NF1 deficiency drives metabolic reprogramming in ER+ breast cancer.

Read more here; https://t.co/OBFAAQlFr1

Highlights below 🧵

[Steensma Lab @SteensmaLab]

Highlights:

- NF1 deficiency -> metabolic reprogramming in ER+ BC

- NF1-driven metabolic reprogramming = OXPHOS constraints, glutamine TCA influx, & lipid pool expansion

- NF1-deficient ER+ BC cells have increased sensitivity to combined RAS + triglyceride synthesis inhibitors

[Alli C. Román-Robinson, MSW @AlliCRoman]

Welcoming our newest cohort! Welcome to our 12 newest students in our PhD program!

#PhDinMolecularandCellularBiology @VAInstitute #biomedicalsciences #futurebiomedicalleaders 🧬🧫🔬🧪

[Steensma Lab @SteensmaLab]

How we feel about getting the official Notice of Award for @pat_dischi’s successful F99/K00 🎉 congratulations Patrick!

[Steensma Lab @SteensmaLab]

Congratulations to our two new graduates - Dr Lauren McGee and Dr Menusha Arumugam! 🎓🎓 Both are moving on to postdoc positions; Lauren @sydney51605 with the LeBlanc Lab at NIH and Menusha @amenusha with the @Hilgendorf_Lab at U of Utah. We will always be rooting for you 💙

[Menusha Arumugam @amenusha]

All the love and support I had through the past 6 years was condensed into such a special graduation day! Officially a @SteensmaLab and @VAInstitute Graduate School alumni! 💙🤍 Excited to move out west this summer and start the next stage of my journey with the @Hilgendorf_Lab

[Steensma Lab @SteensmaLab]

Having a great time talking science and meeting cool people at the Mammary Gland GRC! @Mammary_journal @GordonConf #MGBGRC2023